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Glenfield Hospital","Leicester","England","LE3 9QP","United Kingdom","UK",{"type":60,"coordinates":603},[604,605],-1.13169,52.6386,{"lat":605,"lon":604},{"facility":608,"status":53,"city":609,"state":610,"zip":611,"country":600,"countryCode":601,"cosmosGeoPoint":612,"geoPoint":616,"contacts":11},"St Bartholomew's Hospital - PPDS","London","Greater London","EC1A 7BE",{"type":60,"coordinates":613},[614,615],-0.12574,51.50853,{"lat":615,"lon":614},{"facility":618,"status":53,"city":619,"state":620,"zip":621,"country":600,"countryCode":601,"cosmosGeoPoint":622,"geoPoint":626,"contacts":11},"Southampton General Hospital","Southampton","Hampshire","SO16 6YD",{"type":60,"coordinates":623},[624,625],-1.40428,50.90395,{"lat":625,"lon":624},{"facility":628,"status":53,"city":629,"state":630,"zip":631,"country":600,"countryCode":601,"cosmosGeoPoint":632,"geoPoint":636,"contacts":11},"Royal Infirmary of Edinburgh","Edinburgh","Scotland","EH16 4SA",{"type":60,"coordinates":633},[634,635],-3.19648,55.95206,{"lat":635,"lon":634},{"facility":638,"status":53,"city":639,"state":630,"zip":640,"country":600,"countryCode":601,"cosmosGeoPoint":641,"geoPoint":645,"contacts":11},"Perth Royal Infirmary","Perth","PH1 1NX",{"type":60,"coordinates":642},[643,644],-3.43139,56.39522,{"lat":644,"lon":643},{"facility":647,"status":53,"city":648,"state":11,"zip":649,"country":600,"countryCode":601,"cosmosGeoPoint":650,"geoPoint":654,"contacts":11},"Birmingham Heartlands Hospital","Birmingham","B3 3HX",{"type":60,"coordinates":651},[652,653],-1.89983,52.48142,{"lat":653,"lon":652},{"facility":656,"status":53,"city":609,"state":11,"zip":657,"country":600,"countryCode":601,"cosmosGeoPoint":658,"geoPoint":660,"contacts":11},"Royal Brompton Hospital","SW3 6NP",{"type":60,"coordinates":659},[614,615],{"lat":615,"lon":614},{"type":662,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100614812","study-to-evaluate-the-efficacy-safety-and-tolerability-of-pipe-791-in-subjects-with-idiopathic-pulmonary-fibrosis-100614812",false,"NCT07284459","Study to Evaluate the Efficacy, Safety, and Tolerability of PIPE 791 in Subjects With Idiopathic Pulmonary Fibrosis","A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy, Safety, and Tolerability of Oral PIPE 791 in Subjects With Idiopathic Pulmonary Fibrosis","Key Inclusion Criteria:\n\n* Male or female ≥ 40 years of age at the time of Randomization.\n* A diagnosis of IPF within 7 years prior to Screening, based on the 2022 ATS\u002FERS\u002FJRS\u002FALAT practice guideline as confirmed by the Investigator, and a centrally read screening HRCT consistent with usual interstitial pneumonia (UIP) or probable UIP.\n* Percent predicted (pp) FVC ≥ 40% on Screening spirometry.\n* Participants may enter the study whether or not they are receiving background nintedanib or pirfenidone therapy approved for the treatment of IPF, but not both concurrently.\n\nKey Exclusion Criteria:\n\n* Those with a history of interstitial lung disease (ILD) other than IPF are not eligible.\n* Those with pulmonary arterial hypertension (PAH) requiring multi-drug therapy are not eligible.\n* Those who have experienced an IPF exacerbation within 6 weeks of Screening, or during Screening, are not eligible.\n* Those with an estimated glomerular filtration rate (eGFR) ≤ 30 ml\u002Fmin\u002F1.73 m2 (Chronic Kidney Disease Epidemiology Collaboration \\[CKD-EPI\\] formula) (Inker 2021) or who have Child-Pugh Class B or C hepatic impairment are not eligible.\n* Female participants must not be of childbearing potential.\n\nAdditional inclusion and exclusion criteria apply.","ALL","40 Years",{"count":673,"type":674},324,"ESTIMATED","INTERVENTIONAL",[677],"PHASE2","This is a Ph 2, randomized, double-blind, placebo-controlled global multicenter study to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of PIPE-791 in participants with a diagnosis of Idiopathic Pulmonary Fibrosis (IPF) with or without background treatment.",[680],"Idiopathic Pulmonary Fibrosis",[680,682,683,684,685,686],"PIPE 791","Pulmonary Fibrosis","IPF","ILD","Interstitial lung disease","2026-08-19",{"date":689,"type":690},"2026-08-20","ACTUAL",{"date":692,"type":690},"2026-01-08",{"date":694,"type":674},"2028-06",{"name":5,"class":6},68]