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Glenfield Hospital","Leicester","England","LE3 9QP","United Kingdom","UK",{"type":97,"coordinates":656},[657,658],-1.13169,52.6386,{"lat":658,"lon":657},{"facility":661,"status":90,"city":662,"state":663,"zip":664,"country":653,"countryCode":654,"cosmosGeoPoint":665,"geoPoint":669,"contacts":11},"St Bartholomew's Hospital - PPDS","London","Greater London","EC1A 7BE",{"type":97,"coordinates":666},[667,668],-0.12574,51.50853,{"lat":668,"lon":667},{"facility":671,"status":90,"city":672,"state":673,"zip":674,"country":653,"countryCode":654,"cosmosGeoPoint":675,"geoPoint":679,"contacts":11},"Southampton General Hospital","Southampton","Hampshire","SO16 6YD",{"type":97,"coordinates":676},[677,678],-1.40428,50.90395,{"lat":678,"lon":677},{"facility":681,"status":90,"city":682,"state":683,"zip":684,"country":653,"countryCode":654,"cosmosGeoPoint":685,"geoPoint":689,"contacts":11},"Royal Infirmary of Edinburgh","Edinburgh","Scotland","EH16 4SA",{"type":97,"coordinates":686},[687,688],-3.19648,55.95206,{"lat":688,"lon":687},{"facility":691,"status":90,"city":692,"state":683,"zip":693,"country":653,"countryCode":654,"cosmosGeoPoint":694,"geoPoint":698,"contacts":11},"Perth Royal Infirmary","Perth","PH1 1NX",{"type":97,"coordinates":695},[696,697],-3.43139,56.39522,{"lat":697,"lon":696},{"facility":700,"status":90,"city":701,"state":11,"zip":702,"country":653,"countryCode":654,"cosmosGeoPoint":703,"geoPoint":707,"contacts":11},"Birmingham Heartlands Hospital","Birmingham","B3 3HX",{"type":97,"coordinates":704},[705,706],-1.89983,52.48142,{"lat":706,"lon":705},{"facility":709,"status":90,"city":662,"state":11,"zip":710,"country":653,"countryCode":654,"cosmosGeoPoint":711,"geoPoint":713,"contacts":11},"Royal Brompton Hospital","SW3 6NP",{"type":97,"coordinates":712},[667,668],{"lat":668,"lon":667},{"type":715,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100614812","study-to-evaluate-the-efficacy-safety-and-tolerability-of-pipe-791-in-subjects-with-idiopathic-pulmonary-fibrosis-100614812",false,"NCT07284459","Study to Evaluate the Efficacy, Safety, and Tolerability of PIPE 791 in Subjects With Idiopathic Pulmonary Fibrosis","A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy, Safety, and Tolerability of Oral PIPE 791 in Subjects With Idiopathic Pulmonary Fibrosis","Key Inclusion Criteria:\n\n* Male or female ≥ 40 years of age at the time of Randomization.\n* A diagnosis of IPF within 7 years prior to Screening, based on the 2022 ATS\u002FERS\u002FJRS\u002FALAT practice guideline as confirmed by the Investigator, and a centrally read screening HRCT consistent with usual interstitial pneumonia (UIP) or probable UIP.\n* Percent predicted (pp) FVC ≥ 40% on Screening spirometry.\n* Participants may enter the study whether or not they are receiving background nintedanib or pirfenidone therapy approved for the treatment of IPF, but not both concurrently.\n\nKey Exclusion Criteria:\n\n* Those with a history of interstitial lung disease (ILD) other than IPF are not eligible.\n* Those with pulmonary arterial hypertension (PAH) requiring multi-drug therapy are not eligible.\n* Those who have experienced an IPF exacerbation within 6 weeks of Screening, or during Screening, are not eligible.\n* Those with an estimated glomerular filtration rate (eGFR) ≤ 30 ml\u002Fmin\u002F1.73 m2 (Chronic Kidney Disease Epidemiology Collaboration \\[CKD-EPI\\] formula) (Inker 2021) or who have Child-Pugh Class B or C hepatic impairment are not eligible.\n* Female participants must not be of childbearing potential.\n\nAdditional inclusion and exclusion criteria apply.","ALL","40 Years",{"count":726,"type":727},324,"ESTIMATED","INTERVENTIONAL",[730],"PHASE2","This is a Ph 2, randomized, double-blind, placebo-controlled global multicenter study to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of PIPE-791 in participants with a diagnosis of Idiopathic Pulmonary Fibrosis (IPF) with or without background treatment.",[733],"Idiopathic Pulmonary Fibrosis",[733,735,736,737,738,739],"PIPE 791","Pulmonary Fibrosis","IPF","ILD","Interstitial lung disease","2026-09-10",{"date":742,"type":743},"2026-09-11","ACTUAL",{"date":745,"type":743},"2026-01-08",{"date":747,"type":727},"2028-06",{"name":5,"class":6},70]