[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100659855":3},{"organization":4,"outcomesModule":7,"designInfo":27,"detailedDescription":26,"studyPopulation":26,"armGroups":33,"interventions":45,"overallOfficials":53,"centralContacts":58,"locations":63,"responsibleParty":81,"collaborators":26,"id":83,"slug":84,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":85,"sex":91,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":26,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":26,"overallStatus":66,"whyStopped":26,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"King Edward Medical University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":26},[9],{"measure":10,"description":11,"timeFrame":12},"Venous Clinical Severity Score","Change in Venous Clinical Severity Score (VCSS) from baseline to postoperative follow-up will be assessed to compare clinical improvement between patients undergoing subfascial endoscopic perforator surgery and open perforator ligation.","1 and 2 months follow up",[14,18,22],{"measure":15,"description":16,"timeFrame":17},"Recurrence of Lower Limb Varicosities","Presence of recurrent varicosities in the treated limb during follow-up after surgery.","1 month",{"measure":19,"description":20,"timeFrame":21},"Postoperative Wound Complications","Occurrence of wound infection, wound dehiscence, hematoma, or delayed wound healing following surgery.","Within 30 days after surgery",{"measure":23,"description":24,"timeFrame":25},"Visual Analogue Scale for Pain","Postoperative pain will be assessed using the Visual Analogue Scale (VAS), with pain intensity recorded at follow-up and compared between the subfascial endoscopic perforator surgery and open perforator ligation groups.","24 hours",null,{"allocation":28,"interventionModel":29,"interventionModelDescription":26,"primaryPurpose":30,"observationalModel":26,"timePerspective":26,"maskingInfo":31},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":32,"maskingDescription":26,"whoMasked":26},"NONE",[34,40],{"label":35,"type":36,"description":37,"interventionNames":38},"SubFascial Endoscopic Perforator Surgery","ACTIVE_COMPARATOR","Participants in this group will undergo subfascial endoscopic perforator surgery (SEPS) for treatment of incompetent perforator veins associated with lower limb varicosities. The procedure involves endoscopic identification and division of incompetent perforating veins through small incisions, with the aim of reducing venous reflux and improving clinical outcomes.",[39],"Procedure: Subfascial Endoscopic Perforator Surgery(SEPS)",{"label":41,"type":36,"description":42,"interventionNames":43},"Open Perforator Ligation(Stab Avulsion)","Participants in this group will undergo conventional open surgical ligation(Stab Avulsion) and division of incompetent perforating veins for treatment of lower limb varicosities. The clinical and postoperative outcomes will be compared with those of participants undergoing SEPS.",[44],"Procedure: Open Perforator Ligation(Stab Avulsion)",[46,50],{"type":47,"name":48,"description":37,"armGroupLabels":49,"otherNames":26},"PROCEDURE","Subfascial Endoscopic Perforator Surgery(SEPS)",[35],{"type":47,"name":41,"description":51,"armGroupLabels":52,"otherNames":26},"Participants in this group will undergo conventional open surgical ligation(Stab Avulsion) and division of incompetent perforating veins for treatment of lower limb varicosities. The clinical and postoperative outcomes will be compared with those of participants undergoing SEPS",[41],[54],{"name":55,"affiliation":56,"role":57},"Muhammad Usman, MBBS","King Edward Medical University (KEMU) Lahore","PRINCIPAL_INVESTIGATOR",[59],{"name":55,"role":60,"phone":61,"phoneExt":26,"email":62},"CONTACT","+923124010222","m.usman1320@gmail.com",[64],{"facility":65,"status":66,"city":67,"state":68,"zip":69,"country":70,"countryCode":71,"cosmosGeoPoint":72,"geoPoint":77,"contacts":78},"King Edward Medical University(KEMU), Lahore","RECRUITING","Lahore","Punjab Province","54000","Pakistan","PK",{"type":73,"coordinates":74},"Point",[75,76],74.35071,31.558,{"lat":76,"lon":75},[79,80],{"name":55,"role":60,"phone":61,"phoneExt":26,"email":62},{"name":55,"role":57,"phone":26,"phoneExt":26,"email":26},{"type":82,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100659855","subfascial-endoscopic-perforator-surgery-seps-versus-open-ligation-for-lower-limb-varicose-veins-100659855",false,"NCT07872150","Subfascial Endoscopic Perforator Surgery (SEPS) Versus Open Ligation for Lower Limb Varicose Veins","\"COMPARATIVE OUTCOMES OF SUBFASCIAL ENDOSCOPIC PERFORATOR SURGERY (SEPS) VERSUS OPEN LIGATION FOR TREATING LOWER LIMB VARICOSITIES\"","SEPS","Inclusion Criteria:\n\nAged 18-70 years. Diagnosed with lower limb varicose veins with incompetent perforating veins confirmed by duplex ultrasonography.\n\nCEAP clinical classification C4-C6 (advanced chronic venous insufficiency). Fit for elective surgery under spinal or general anesthesia.\n\nExclusion Criteria:\n\nRecurrent varicose veins after previous interventions. Deep vein thrombosis (DVT) or extensive deep venous obstruction. Severe systemic comorbidities contraindicating surgery. Patients unwilling to provide informed consent","ALL","18 Years","70 Years",{"count":95,"type":96},62,"ESTIMATED","INTERVENTIONAL",[99],"NA","The goal of this study is to compare two surgical treatments for lower limb varicose veins: subfascial endoscopic perforator surgery (SEPS) and open perforator ligation. Patients undergoing treatment for lower limb varicose veins will receive one of these surgical procedures. The study will compare postoperative outcomes, recovery, and complications between the two groups to determine which surgical approach provides better outcomes.",[102],"Varicose Veins of Lower Limb","2026-10-07",{"date":105,"type":106},"2026-10-13","ACTUAL",{"date":108,"type":106},"2026-07-10",{"date":110,"type":96},"2027-01-01",{"name":5,"class":6},1]