[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647351":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":41,"centralContacts":45,"locations":51,"responsibleParty":70,"collaborators":49,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":49,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":49,"studyType":85,"phases":86,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":96,"whyStopped":49,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"University of Minnesota","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Formulation A","ACTIVE_COMPARATOR","Two sachets nested between the lower jaw, gum, and cheek; outer sachet 100 mg CD\u002F0mg LD and inner sachet 0mg CD \u002F400mg LD",[13],"Drug: Formulation A",{"label":15,"type":10,"description":16,"interventionNames":17},"Formulation B","Two sachets nested between the lower jaw, gum, and cheek; outer sachet 150mg CD\u002F0mg LD and inner sachet 600mg LD",[18],"Drug: Formulation B",{"label":20,"type":10,"description":21,"interventionNames":22},"Formulation C","Two sachets nested between the lower jaw, gum, and cheek; outer sachet 200mg CD\u002F0mg LD and inner sachet 800mg LD",[23],"Drug: Formulation C",[25,31,36],{"type":26,"name":9,"description":27,"armGroupLabels":28,"otherNames":29},"DRUG","outer sachet 100 mg CD\u002F0mg LD and inner sachet 0mg CD \u002F400mg LD",[9],[30],"Study Drug A",{"type":26,"name":15,"description":32,"armGroupLabels":33,"otherNames":34},"outer sachet 150mg CD\u002F0mg LD and inner sachet 600mg LD",[15],[35],"Study Drug B",{"type":26,"name":20,"description":37,"armGroupLabels":38,"otherNames":39},"outer sachet 200mg CD\u002F0mg LD and inner sachet 800mg LD",[20],[40],"Study Drug C",[42],{"name":43,"affiliation":5,"role":44},"Khalaf Bushara, MD, FRCP","PRINCIPAL_INVESTIGATOR",[46],{"name":43,"role":47,"phone":48,"phoneExt":49,"email":50},"CONTACT","‪(612) 460-5734‬",null,"umnstudies@gmail.com",[52],{"facility":5,"status":49,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Minneapolis","Minnesota","55455","United States","US",{"type":59,"coordinates":60},"Point",[61,62],-93.26384,44.97997,{"lat":62,"lon":61},[65,69],{"name":43,"role":47,"phone":66,"phoneExt":67,"email":68},"612-725-2000","x4233","busha001@umn.edu",{"name":43,"role":44,"phone":49,"phoneExt":49,"email":49},{"type":71,"investigatorFullName":49,"investigatorTitle":49,"investigatorAffiliation":49,"oldNameTitle":49,"oldOrganization":49},"SPONSOR","100647351","sustained-release-oral-formulation-for-treatment-of-parkinsons-disease-100647351",false,"NCT07709741","Sustained Release Oral Formulation For Treatment Of Parkinsons Disease","Inclusion Criteria:\n\n* Adult healthy male or female\n* Age 18 to 65 years\n* Willingness and ability to complete study procedures\n\nExclusion Criteria:\n\n* medical conditions that require taking medications regularly.",true,"ALL","18 Years","65 Years",{"count":83,"type":84},32,"ESTIMATED","INTERVENTIONAL",[87,88],"PHASE1","PHASE2","LD\u002FCD (medications to treat Parkinson's disease) will be delivered using an assembly of nested sachets made of permeable material. The assembly is placed in the oral\u002Fbuccal cavity (between cheek and gum of lower jaw) and delivers continuous release of CD and LD for both transmucosal and gastrointestinal absorption. The combination of CD\u002FLD in the inner sachet varies from that in the outer sachet. This allows for sequential release of CD and then LD to mimic a CD pretreatment method which is known to increase LD absorption and prolong its half-life.",[91],"Healthy Volunteers",[93,94,95],"Parkinson's","Levidopa","Carbidopa","NOT_YET_RECRUITING","2026-08-06",{"date":99,"type":100},"2026-08-10","ACTUAL",{"date":102,"type":84},"2026-09-30",{"date":104,"type":84},"2027-06-30",{"name":5,"class":6},1]