[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652321":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":21,"collaborators":10,"id":25,"slug":26,"hasResults":27,"nctId":28,"briefTitle":29,"officialTitle":30,"acronym":10,"eligibilityCriteria":31,"healthyVolunteers":27,"sex":32,"minAge":33,"maxAge":34,"enrollmentInfo":35,"targetDuration":10,"studyType":38,"phases":10,"briefSummary":39,"conditions":40,"keywords":45,"overallStatus":57,"whyStopped":10,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":10},{"fullName":5,"class":6},"Assiut University","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"T2DM with Normoalbuminuria",null,"30 adult patients diagnosed with type 2 diabetes mellitus presenting with normoalbuminuria, defined as urinary albumin-to-creatinine ratio (uACR) \\\u003C 30 mg\u002Fg creatinine.",{"label":13,"type":10,"description":14,"interventionNames":10},"T2DM with Microalbuminuria","30 adult patients diagnosed with type 2 diabetes mellitus presenting with microalbuminuria, defined as urinary albumin-to-creatinine ratio (uACR) between 30 and 299 mg\u002Fg creatinine.",{"label":16,"type":10,"description":17,"interventionNames":10},"T2DM with Macroalbuminuria","30 adult patients diagnosed with type 2 diabetes mellitus presenting with macroalbuminuria, defined as urinary albumin-to-creatinine ratio (uACR) ≥ 300 mg\u002Fg creatinine.",{"label":19,"type":10,"description":20,"interventionNames":10},"Healthy Controls","30 age- and sex-matched healthy control individuals without diabetes, renal impairment, or chronic inflammatory disease.",{"type":22,"investigatorFullName":23,"investigatorTitle":24,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Eman Ali Mohammed Ali","Resident of Clinical Pathology","100652321","systemic-immune-inflammation-index-and-platelet-parameters-in-diabetic-kidney-disease-100652321",false,"NCT07773467","Systemic Immune-Inflammation Index and Platelet Parameters in Diabetic Kidney Disease","Systemic Immune Inflammation Index With Related Blood Ratios and Platelet Parameters in Patients With Type 2 Diabetes Mellitus and Nephropathy","Inclusion Criteria:\n\n* Adults aged 18 to 80 years, both males and females.\n* Confirmed clinical diagnosis and history of Type 2 Diabetes Mellitus (T2DM).\n* Healthy control subjects matched for age and sex (for the control cohort).\n\nExclusion Criteria:\n\n* Type 1 diabetes mellitus.\n* Acute infections or clinical signs of active inflammation at the time of sampling.\n* Chronic inflammatory or autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus).\n* Known or recently diagnosed malignancies.\n* Chronic liver diseases, including cirrhosis or hepatitis.\n* Nephrotic syndrome or other known non-diabetic kidney diseases.\n* History of immunosuppressive therapy, systemic corticosteroids, or cytotoxic medications within the past 3 months prior to enrollment.\n* Pregnancy.\n* Significant cardiovascular complications.","ALL","18 Years","80 Years",{"count":36,"type":37},120,"ESTIMATED","OBSERVATIONAL","Diabetic kidney disease (DKD) is a frequent microvascular complication in individuals with type 2 diabetes mellitus (T2DM) and a major cause of chronic kidney failure worldwide. Chronic low-grade inflammation and platelet activation contribute significantly to renal microvascular damage.\n\nThe purpose of this observational study is to evaluate whether routine blood test markers, specifically the Systemic Immune-Inflammation Index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and platelet indices (such as mean platelet volume \\[MPV\\] and platelet distribution width \\[PDW\\]), can serve as simple, accessible, and cost-effective biomarkers for identifying the presence and progression of diabetic kidney disease.\n\nParticipants will include adult patients with type 2 diabetes categorized according to their urinary albumin-to-creatinine ratio (normoalbuminuria, microalbuminuria, and macroalbuminuria) as well as healthy control subjects. Complete blood counts, derived inflammatory indices, and renal parameters will be measured to assess their diagnostic accuracy for DKD.",[41,42,43,44],"Diabetic Kidney Disease","Diabetic Nephropathies","Type 2 Diabetes Mellitus","Albuminuria",[46,47,48,49,50,51,52,53,54,55,56],"Systemic Immune-Inflammation Index","SII","Neutrophil-to-Lymphocyte Ratio","NLR","Platelet-to-Lymphocyte Ratio","PLR","Mean Platelet Volume","MPV","Platelet Parameters","Platelet Distribution Width","Inflammatory Biomarkers","NOT_YET_RECRUITING","2026-08-15",{"date":60,"type":61},"2026-08-19","ACTUAL",{"date":63,"type":37},"2026-09",{"date":65,"type":37},"2027-10",{"name":5,"class":6}]