[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645527":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":55,"collaborators":25,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":25,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":25,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":38,"whyStopped":25,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Central South University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"sham group","SHAM_COMPARATOR","sham stimulation",[13],"Device: sham stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"active group","EXPERIMENTAL","transcranial alternating current stimulation",[19],"Device: transcranial alternating current stimulation",[21,26],{"type":22,"name":17,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","For montage 1, active electrode at P3 (10-10 system), return electrodes at P1, P5, PO3, CP3. For montage 2, active electrode at P4, return electrodes at P2, P6, PO4, CP4. Conductive paste ensures impedance \\\u003C10 kΩ. Individual alpha frequency is used, calculated before each session from mean EEG at P3\u002FP4 during SIRP task. Stimulation intensity is 2 mA (peak-to-zero) via electric field modeling. Stimulation is delivered during SIRP task, 30 min total per session (including 15s ramp-up\u002Fdown), with continuous sine wave output.",[15],null,{"type":22,"name":11,"description":27,"armGroupLabels":28,"otherNames":25},"Sham stimulation provides only a 15-second ramp-up and ramp-down current at the beginning and end of each session to mimic the initial tingling or itching sensation on the scalp produced by real stimulation, but delivers no effective stimulation current during the main phase of the task period.",[9],[30],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Renrong Wu","CONTACT","15874179855","wurenrong@csu.edu.cn",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"The Second Xiangya Hospital of Central South University","RECRUITING","Changsha","Hunan","410011","China","CN",{"type":45,"coordinates":46},"Point",[47,48],112.97087,28.19874,{"lat":48,"lon":47},[51],{"name":52,"role":32,"phone":53,"phoneExt":25,"email":54},"Jimin Zhang","18738858423","zhangjimin@csu.edu.cn",{"type":56,"investigatorFullName":31,"investigatorTitle":57,"investigatorAffiliation":58,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Professor","Second Xiangya Hospital of Central South University","100645527","tacs-for-working-memory-in-schizophrenia-100645527",false,"NCT07701343","tACS for Working Memory in Schizophrenia","Efficacy and Mechanisms of Transcranial Alternating Current Stimulation in Improving Working Memory in Patients With Schizophrenia","Inclusion Criteria:\n\n* Aged 18-50 years, meeting the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic criteria for schizophrenia, confirmed by the Structured Clinical Interview for DSM-5 (SCID-5).\n* Spatial span T-score \\\u003C40 on the MATRICS Consensus Cognitive Battery (MCCB).\n* Taking 1-2 antipsychotic medications, with stable dosage for at least 1 week prior to enrollment. No use of mood stabilizers, antidepressants, or excessive benzodiazepines (lorazepam equivalent \\>2 mg\u002Fday). The type and dosage of antipsychotic medications remain unchanged during the treatment period.\n* Impaired functioning in daily activities.\n* Willing to participate in this study and provide written informed consent.\n\nExclusion Criteria:\n\n* Previously diagnosed with or comorbid any other DSM-5 mental disorder besides schizophrenia.\n* Presence of significant mood symptoms or substance use disorder (other than caffeine and\u002For tobacco).\n* Presence of any contraindication to transcranial alternating current stimulation (tACS).\n* Received other forms of electrical or magnetic stimulation therapy within 1 month prior to enrollment.\n* History or current presence of any major physical illness, neurological disorder, or traumatic brain injury that may affect brain structure or function.\n* Pregnant or breastfeeding women, or women planning to become pregnant during the study period.","ALL","18 Years","50 Years",{"count":70,"type":71},30,"ESTIMATED","INTERVENTIONAL",[74],"NA","This study is a randomized, single-blind, sham-controlled crossover trial enrolling 30 schizophrenia patients, each receiving one active and one sham tACS session (7-day washout), targeting P3\u002FP4 at individual alpha frequency (2mA, 30min) during a working memory task, with accuracy and reaction time as primary outcomes, alongside EEG and neurophysiological measures, to test the efficacy and mechanisms of individualized alpha-tACS on working memory.",[77,78],"Schizophrenia","Working Memory",[77,78,80],"Transcranial Alternating Current Stimulation","2026-07-08",{"date":83,"type":84},"2026-07-14","ACTUAL",{"date":86,"type":71},"2026-07-06",{"date":88,"type":71},"2026-12-31",{"name":5,"class":6},1]