[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100609833":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":41,"responsibleParty":59,"collaborators":26,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":26,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":26,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"University of Wisconsin, Madison","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Stimulation","EXPERIMENTAL","Participants will complete two stimulation phases-overnight TI-TES during non-rapid eye movement (NREM) sleep and TI-TES during quiet wakefulness",[13],"Device: Temporal Interference Transcranial electrical stimulation (TI-TES)",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham stimulation","SHAM_COMPARATOR","\\~10 participants will be assigned to sham stimulation",[19],"Device: Sham stimulation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Temporal Interference Transcranial electrical stimulation (TI-TES)","TI-TES uses specific electrode arrangement patterns to selectively stimulate the brain. Participants will wear an hdEEG (high density electroencephalography) cap which will allow intermittent periods of stimulation from TI-TES.",[9],null,{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":26},"Sham (ramp only) stimulation will briefly ramp up and down at the beginning and end of each stimulation train, without delivering continuous stimulation throughout.",[15],[31],{"name":32,"affiliation":5,"role":33},"Larissa Albantakis, PhD","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":26,"email":39},"TITAN Study Team","CONTACT","6082634313","titan@psychiatry.wisc.edu",{"name":32,"role":37,"phone":26,"phoneExt":26,"email":26},[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"University of Wisconsin - Madison","RECRUITING","Madison","Wisconsin","53705","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-89.40123,43.07305,{"lat":54,"lon":53},[57],{"name":36,"role":37,"phone":58,"phoneExt":26,"email":39},"608-263-4313",{"type":60,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100609833","temporal-interference-for-thalamocortical-activity-and-network-modulation-100609833",false,"NCT07219719","Temporal Interference for Thalamocortical Activity and Network Modulation","TITAN","Inclusion Criteria:\n\n* Adults aged 18-50\n* Medically healthy\n* U.S. citizen or holding permanent resident status\n* English-speaking\n\nExclusion Criteria:\n\n* Any current or past history of neurological disorders or acquired neurological disease (e.g. stroke, traumatic brain injury), including intracranial lesions (including clinically significant findings identified in first MRI)\n* History of inpatient psychiatric hospitalization\n* History of head trauma resulting in prolonged loss of consciousness; or a history of greater than 3 grade I concussions\n* Current history of poorly controlled headaches including intractable or poorly controlled migraines\n* Any systemic illness or unstable medical condition that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.)\n* History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG, or family history of treatment resistant epilepsy except for a single seizure of benign etiology (e.g. febrile seizures) in the judgment of a board-certified neurologist\n* Possible pregnancy or plan to become pregnant in the next 6 months (self reported)\n* Any metal in the head\n* Any medical devices or implants (i.e. cardiac pacemaker, medication infusion pump, cochlear implant, vagal nerve stimulator)\n* Dental implants\n* Permanent retainers\n* Any hair braid, dreadlocks, hair pieces, or extensions which cannot be taken out before the study sessions\n* Any head coverings or headdress that participant feels uncomfortable removing for the purposes of study sessions\n* Any medication that may alter seizure threshold taken during the study i.e., Attention-deficit\u002Fhyperactivity disorder (ADHD) stimulants (Adderall, amphetamine); Tricyclic\u002Fatypical antidepressants (amitriptyline, doxepin, imipramine, maprotiline, nortriptyline, bupropion); SSRIs (Escitalopram, Fluoxetine, Sertraline); Antipsychotics (chlorpromazine, clozapine), Bronchodilators (theophylline, aminophylline); Antibiotics (fluoroquinolones, imipenem, penicillin, cephalosporins, metronidazole, isoniazid); Antivirals (valacyclovir, ritonavir); over the counter antihistamines (diphenhydramine, Benadryl); Estradiol-based birth control\n* Claustrophobia (a fear of small or closed places)\n* Back problems that would prevent lying flat for up to two hours\n* Regular night-shift work (second or third shift)\n* Sleep apnea or other sleep disorder (self-reported)",true,"ALL","18 Years","50 Years",{"count":73,"type":74},40,"ESTIMATED","INTERVENTIONAL",[77],"PHASE1","The goal of this clinical trial is to find out whether a type of electrical brain stimulation, called temporal interference stimulation, can temporarily change the way different parts of the brain communicate with each other.\n\nParticipants will:\n\n* Complete two stimulation phases - overnight and during wakefulness\n* Undergo two MRIs per study phase",[80],"Healthy Participants","2026-08-06",{"date":83,"type":84},"2026-08-10","ACTUAL",{"date":86,"type":84},"2025-12-01",{"date":88,"type":74},"2027-11",{"name":5,"class":6},1]