[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635905":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":42,"responsibleParty":60,"collaborators":25,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":25,"eligibilityCriteria":68,"healthyVolunteers":65,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":25,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":82,"overallStatus":44,"whyStopped":25,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Emory University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Temporal Interference (TI) stimulation","EXPERIMENTAL","Participants will receive active stimulation for each of 5 intervention sessions, and will receive TI stimulation for a total time of 20-60 minutes. Stimulation will occur during presentation of the visual stimuli on which subjects will conduct behavioral or cognitive tasks.",[13],"Device: Electrical stimulation device",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham TI stimulation","SHAM_COMPARATOR","Participants will receive sham stimulation for each of 5 intervention sessions, where carrier frequency (e.g., 5000Hz) will be applied but no envelope frequency or 0Hz frequency will be applied.",[13],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Electrical stimulation device","Temporal Interference (TI) stimulation is a non-invasive neuromodulation method which allows focal electrical stimulation of deep brain structures without affecting overlying cortical regions. Areas will be targeted based on tasks being administered under TI and will include areas associated with fear\u002Fanxiety expression and inhibition, reward, and general affective processing including cortical areas. Two carrier electric fields offset by a small amount (5-130Hz) will occur during stimulation.\n\nStimulation will be applied between the pairs of electrodes with a current up to a maximum of between 8mA (TI outside the scanner) and 10mA (TI inside the scanner) with envelope frequencies between 1hz-200hz. Multipolar TI will also be used with multiple locations that can be targeted for stimulation by adding more pairs of electrodes.",[9],null,{"type":21,"name":22,"description":27,"armGroupLabels":28,"otherNames":25},"Electrodes will be placed in the same locations used for the TI intervention; either a carrier frequency or no electrical current will be delivered to the brain.",[15],[30],{"name":31,"affiliation":5,"role":32},"Negar Fani, PhD, ABPP","PRINCIPAL_INVESTIGATOR",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},"Rachel Jones","CONTACT","404-712-0354","gtpaffectneurolab@emory.edu",{"name":40,"role":36,"phone":25,"phoneExt":25,"email":41},"Alisha Sylvester","alisha.marie.sylvester@emory.edu",[43],{"facility":5,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Atlanta","Georgia","30322","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-84.38798,33.749,{"lat":54,"lon":53},[57,59],{"name":35,"role":36,"phone":25,"phoneExt":25,"email":58},"rachel.ivy.jones@emory.edu",{"name":31,"role":32,"phone":25,"phoneExt":25,"email":25},{"type":32,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Negar Fani","Associate Professor","100635905","temporal-interference-in-psychiatry-tip-neuromodulation-using-temporal-interference-100635905",false,"NCT07558759","Temporal Interference in Psychiatry (TIP): Neuromodulation Using Temporal Interference","Inclusion Criteria:\n\n* Written informed consent.\n* Fluent English speaker.\n* Both sexes and all ethnic origins, between 18 and 65 years old.\n* Absence of current moderate to severe illicit drug use as assessed by subject history (AUDIT\\>=8 and\u002For DAST\\>2).\n\nExclusion Criteria:\n\n* Pregnant or currently breast-feeding women or any woman of childbearing potential who is seeking to become pregnant or suspects that she may be pregnant, as assessed by subject report and\u002For urine pregnancy screen.\n* Contraindications to MRI scanning (including presence of a cardiac pacemaker or pacemaker wires, metallic particles in the body, vascular clips in the head or previous neurosurgery, prosthetic heart valves, claustrophobia, as assessed with the standard MRI screening form from the CABI, FERN or CSI.\n* Unable to fit comfortably in the scanner.\n* Contraindication to TI and\u002For TMS (including history of epilepsy, metallic implants in the head and\u002For neck, brain stimulators, vagus nerve stimulators, VP shunt, pacemakers)\n* Current use of medications that may increase the risk of seizures (e.g., bupropion, varenicline, chlorpromazine, theophylline).\n* History or current serious or unstable medical illness, including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease, as assessed by subject history.\n* History of head injury resulting in more than brief loss of consciousness, as assessed by subject history.\n* Current cocaine or stimulant use (e.g., amphetamine, cocaine, methamphetamine), as assessed by subject history.\n* Evidence of significant inconsistencies in self-report measures.\n* Non-English speakers will be excluded from this study because the research procedures rely heavily on the administration of validated self-report questionnaires, clinical interviews, and task instructions that at this time, are only available in English. Additionally, study staff are trained to administer these assessments and obtain informed consent in English only. Including non-English speakers would therefore pose a risk of misunderstanding study procedures, consent materials, or questionnaire items, which could affect both participant comprehension and data integrity.","ALL","18 Years","65 Years",{"count":73,"type":74},300,"ESTIMATED","INTERVENTIONAL",[77],"NA","This study aims to understand the neural, behavioral and clinical effects of temporal interference (TI), a type of neuromodulation method, in healthy populations and in individuals with anxiety and stress-related conditions.",[80,81],"Anxiety","PTSD",[83],"Temporal Interference","2026-07-14",{"date":86,"type":87},"2026-07-15","ACTUAL",{"date":89,"type":87},"2026-04-07",{"date":91,"type":74},"2031-04",{"name":5,"class":6},1]