[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649000":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":56,"collaborators":26,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":26,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":26,"overallStatus":39,"whyStopped":26,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Xijing Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active TI stimulation","EXPERIMENTAL","Participants will receive twice-daily TI stimulation, administered 4 hours apart or more, for 2 weeks. The current will be applied for 40 minutes per session.",[13],"Device: Active Temporal Interference Stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham TI stimulation","SHAM_COMPARATOR","Participants will receive twice-daily TI stimulation, administered 4 hours apart or more, for 2 weeks. Each session is scheduled for 40 minutes, but actual current is delivered only as a short 30-second pulse at the start and at the end, with no current applied in between.",[19],"Device: Sham Temporal Interference Stimulation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Active Temporal Interference Stimulation","For the active TI stimulation, the current was applied for 40 minutes per session.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Sham Temporal Interference Stimulation","For the sham stimulation, a brief 30-second current was delivered at the beginning and at the end of each session, with no current applied in between.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Bei He","CONTACT","+86-29-84771377","1569451844@qq.com",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Xi'an","Shaanxi","710032","China","CN",{"type":46,"coordinates":47},"Point",[48,49],108.92861,34.25833,{"lat":49,"lon":48},[52],{"name":53,"role":34,"phone":54,"phoneExt":26,"email":55},"Wen Tian Gao","+86-29-84771794","customer@notice.rh-clinical.com",{"type":57,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100649000","temporal-interference-stimulation-of-hypothalamus-in-patients-with-narcolepsy-type-1-100649000",false,"NCT07727239","Temporal Interference Stimulation of Hypothalamus in Patients With Narcolepsy Type 1","Efficacy and Safety of Temporal Interference Stimulation of Hypothalamus in Patients With Narcolepsy Type 1: A Randomised, Double-blind, Sham-Controlled, Single-Centre Trial","TINY","Inclusion Criteria:\n\n* Aged 12 to 60 years.\n* Diagnosis of narcolepsy type 1 according to the International Classification of Sleep Disorders, Third Edition (ICSD-3), confirmed by polysomnography (PSG) and\u002For Multiple Sleep Latency Test (MSLT) performed within the past 10 years, with the test procedures meeting the minimum technical standards specified in the ICSD-3.\n* Epworth Sleepiness Scale score \\>12 at baseline.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Presence of other conditions that cause excessive daytime sleepiness, including restless legs syndrome, periodic limb movement disorder, or moderate-to-severe obstructive sleep apnea syndrome, etc.\n* History of epilepsy, severe neuropsychiatric disorders, or significant cardiac, hepatic, or renal dysfunction.\n* Pregnancy or current breastfeeding.\n* Contraindications to MRI or electrical stimulation therapy, such as intracranial metallic foreign bodies, cardiac pacemakers, implantable cardioverter-defibrillators, or cochlear implants.","ALL","12 Years","60 Years",{"count":70,"type":71},24,"ESTIMATED","INTERVENTIONAL",[74],"NA","Narcolepsy type 1 (NT1) is a chronic brain disorder caused by selective loss or dysfunction of orexin (hypocretin) neurons in the lateral hypothalamus, for which current pharmacological treatments offer limited efficacy. Temporal interference (TI) stimulation is a recently developed noninvasive neuromodulation technique that enables focal modulation of deep brain structures. In this randomized, double-blind study, we developed a theta-burst patterned TI protocol and evaluated its effects in patients with NT1.",[77],"Narcolepsy Type 1","2026-08-03",{"date":80,"type":81},"2026-08-05","ACTUAL",{"date":83,"type":81},"2026-08-01",{"date":85,"type":71},"2027-12",{"name":5,"class":6},1]