[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632321":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":17,"studyPopulation":18,"armGroups":19,"interventions":31,"overallOfficials":45,"centralContacts":50,"locations":55,"responsibleParty":72,"collaborators":13,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":13,"eligibilityCriteria":82,"healthyVolunteers":78,"sex":83,"minAge":84,"maxAge":13,"enrollmentInfo":85,"targetDuration":13,"studyType":88,"phases":13,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":58,"whyStopped":13,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Ain Shams University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Death from any cause.","Occurrence of death from any cause, assessed from the date of onset of symptoms up to 90 days.","From the date of onset of symptoms until the date of death or date of discharge from the hospital, whichever comes first, assessed up to 90 days.",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"COHORT","RETROSPECTIVE","On admission to the intensive care unit, three scoring systems for tetanus severity will be applied to all patients: the Tetanus Severity Score (TSS), Dakar Score, and Philips Score, and will then be related to the occurrence of in-hospital mortality or survival to hospital discharge.","Adults of both sexes with manifest tetanus.",[20,27],{"label":21,"type":13,"description":22,"interventionNames":23},"Non-survivors","Patients who die in hospital",[24,25,26],"Diagnostic Test: Tetanus Severity Score (TSS)","Diagnostic Test: Philips Score","Diagnostic Test: Dakar Score",{"label":28,"type":13,"description":29,"interventionNames":30},"Survivors","Patients who survive to hospital discharge",[24,25,26],[32,37,41],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":13},"DIAGNOSTIC_TEST","Tetanus Severity Score (TSS)","The Tetanus Severity Score (TSS) is calculated for each patient by the investigator using the required data as documented in the medical records at admission",[21,28],{"type":33,"name":38,"description":39,"armGroupLabels":40,"otherNames":13},"Philips Score","The Philips Score is calculated for each patient by the investigator using the required data as documented in the medical records at admission",[21,28],{"type":33,"name":42,"description":43,"armGroupLabels":44,"otherNames":13},"Dakar Score","The Dakar Score is calculated for each patient by the investigator using the required data as documented in the medical records at admission",[21,28],[46],{"name":47,"affiliation":48,"role":49},"Sameh M Hakim, MD","Ain Shams University Faculty of Medicine","STUDY_DIRECTOR",[51],{"name":47,"role":52,"phone":53,"phoneExt":13,"email":54},"CONTACT","+202 26900073","hakimsm@med.asu.edu.eg",[56],{"facility":57,"status":58,"city":59,"state":60,"zip":61,"country":62,"countryCode":63,"cosmosGeoPoint":64,"geoPoint":69,"contacts":70},"Ain Shams University Hospitals & Demanhour Fever Hospital","RECRUITING","Cairo","Cairo Governorate","11341","Egypt","EG",{"type":65,"coordinates":66},"Point",[67,68],31.24967,30.06263,{"lat":68,"lon":67},[71],{"name":47,"role":52,"phone":53,"phoneExt":13,"email":54},{"type":73,"investigatorFullName":74,"investigatorTitle":75,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"PRINCIPAL_INVESTIGATOR","Sameh M. Hakim","Professor of Anesthesiology, Intensive Care and Pain Management","100632321","tetanus-severity-score-for-prediction-of-mortality-in-manifest-tetanus-100632321",false,"NCT07512167","Tetanus Severity Score for Prediction of Mortality in Manifest Tetanus","Comparison of Three Scoring Systems for Prediction of Mortality in Patients Admitted to the Intensive Care Unit With Manifest Tetanus","Inclusion criteria:\n\n* Adults (age 18 years old or more).\n* Any sex (male or female), regardless of gender identity.\n* Diagnosis of manifest tetanus according to the WHO criteria (https:\u002F\u002Fwww.who.int\u002Fnews-room\u002Ffact-sheets\u002Fdetail\u002Ftetanus), that is the presence of one or both of the following criteria with or without the history of specific wound or injury:\n\n  * Sustained spasm of the facial muscles in which person appears grinning.\n  * Painful muscular contractions\n\nExclusion criteria:\n\n* Age \\\u003C 18 years.\n* Absent criteria of manifest tetanus, as per the WHO criteria (https:\u002F\u002Fwww.who.int\u002Fnews-room\u002Ffact-sheets\u002Fdetail\u002Ftetanus).\n* Incomplete medical record with missing data required to calculate the Tetanus Severity Score, Philips Score, or Dakar score.\n* Incomplete medical record with missing data regarding the primary outcome measure (survival to hospital discharge or in-hospital mortality).","ALL","18 Years",{"count":86,"type":87},115,"ESTIMATED","OBSERVATIONAL","Three scoring systems will be applied to patients suffering from manifest tetanus and will be related to mortality.",[91],"Tetanus, Manifest",[93],"Tetanus, Tetanus Severity Score","2026-09-26",{"date":96,"type":97},"2026-09-29","ACTUAL",{"date":99,"type":97},"2026-04-15",{"date":101,"type":87},"2026-11-15",{"name":5,"class":6},1]