[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100451830":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":47,"centralContacts":51,"locations":61,"responsibleParty":84,"collaborators":34,"id":87,"slug":88,"hasResults":89,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":95,"sex":96,"minAge":97,"maxAge":98,"enrollmentInfo":99,"targetDuration":34,"studyType":102,"phases":103,"briefSummary":105,"conditions":106,"keywords":34,"overallStatus":64,"whyStopped":34,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"University of Zurich","OTHER",[8,14,19,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Endurance Exercise - COPD and Healthy Participants (Fixed-Duration Protocol)","EXPERIMENTAL","Both COPD patients and healthy participants will complete two endurance exercise conditions in a randomized, crossover design:\n\n* Blood Flow Restriction Cycling (BFR-CYC)\n* Non-BFR Control Cycling\n\nBFR-CYC: Three intervals of 2 minutes at 50% PWR, separated by 1-minute recovery periods, with bilateral thigh cuffs inflated to 50% LOP during exercise intervals.\n\nControl: Time- and structure-matched protocol (3 × 2 minutes) without blood flow restriction at 65% PWR, with identical recovery periods.",[13],"Other: BFR-CYC 3x2min",{"label":15,"type":10,"description":16,"interventionNames":17},"Resistance Exercise - COPD and Healthy Participants (BFR vs Control, Fixed Protocol)","Both COPD patients and healthy participants will complete two resistance exercise conditions in a randomized, crossover design:\n\n* Blood Flow Restriction Resistance Exercise (BFR-RE)\n* Non-BFR Control Resistance Exercise BFR-RE: Unilateral right-leg press at 40% of one-repetition maximum (1RM) with cuffs inflated to 80% LOP. Protocol: 4 sets (30-15-15-15 repetitions).\n\nControl: Bilateral leg press at 40% 1RM, 3 sets of 15 repetitions, without blood flow restriction.",[18],"Other: BFR Resistance 80% LOP",{"label":20,"type":10,"description":21,"interventionNames":22},"Endurance Exercise - COPD Participants (Exhaustive Protocol)","Patients with COPD will complete three cycling exercise conditions in a randomized, crossover design:\n\n* Blood Flow Restriction Cycling (BFR-CYC)\n* Continuous Cycling (CONT-CYC)\n* Interval Cycling (INT-CYC)",[23],"Other: BFR-CYC 50% peak \u002F 50% AOP (exhaustive)",{"label":25,"type":10,"description":26,"interventionNames":27},"Resistance Exercise - Healthy Participants (LOP Comparison Arm)","Healthy participants will complete two BFR resistance exercise conditions in a randomized, crossover design:\n\n* BFR at 40% LOP\n* BFR at 80% LOP Participants will perform unilateral right-leg press exercise at 40% 1RM using a standardized protocol of 4 sets (30-15-15-15 repetitions) with fixed rest intervals. The protocol will be completed as prescribed (not to volitional exhaustion) unless predefined safety criteria require early termination.",[28],"Other: BFR REsistance 48% vs. 80% LOP",[30,35,39,43],{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"BFR-CYC 50% peak \u002F 50% AOP (exhaustive)","BFR-CYC: Continuous cycling at 50% peak work rate (PWR) with bilateral thigh cuffs inflated to 50% limb occlusion pressure (LOP). A maximum duration of 30 minutes is applied as a safety limit.",[20],null,{"type":6,"name":36,"description":37,"armGroupLabels":38,"otherNames":34},"BFR-CYC 3x2min","BFR-CYC: Three intervals of 2 minutes at 50% PWR, separated by 1-minute recovery periods, with bilateral thigh cuffs inflated to 50% LOP during exercise intervals.",[9],{"type":6,"name":40,"description":41,"armGroupLabels":42,"otherNames":34},"BFR Resistance 80% LOP","BFR-RE: Unilateral right-leg press at 40% of one-repetition maximum (1RM) with cuffs inflated to 80% LOP. Protocol: 4 sets (30-15-15-15 repetitions).",[15],{"type":6,"name":44,"description":45,"armGroupLabels":46,"otherNames":34},"BFR REsistance 48% vs. 80% LOP","* BFR at 40% LOP\n* BFR at 80% LOP All sessions will be conducted on a leg press device under standardized laboratory conditions. Pneumatic cuffs will be applied to the proximal thigh of the right leg.\n\nParticipants will perform unilateral right-leg press exercise at 40% 1RM using a standardized protocol of 4 sets (30-15-15-15 repetitions) with fixed rest intervals. The protocol will be completed as prescribed (not to volitional exhaustion) unless predefined safety criteria require early termination.",[25],[48],{"name":49,"affiliation":5,"role":50},"Christian Clarenbach, Dr. med","PRINCIPAL_INVESTIGATOR",[52,57],{"name":53,"role":54,"phone":55,"phoneExt":34,"email":56},"Christan Clarenbach, Dr. med","CONTACT","044 255 22 21","Christian.clarenbach@usz.ch",{"name":58,"role":54,"phone":59,"phoneExt":34,"email":60},"Manuel Kuhn, PhD Student","0798526722","manuel.kuhn@usz.ch",[62],{"facility":63,"status":64,"city":65,"state":66,"zip":67,"country":68,"countryCode":69,"cosmosGeoPoint":70,"geoPoint":75,"contacts":76},"University Hospital Zürich","RECRUITING","Zurich","Canton of Zurich","8091","Switzerland","CH",{"type":71,"coordinates":72},"Point",[73,74],8.55,47.36667,{"lat":74,"lon":73},[77,80],{"name":78,"role":54,"phone":79,"phoneExt":34,"email":60},"Manuel Kuhn, MSc","0432532681",{"name":81,"role":54,"phone":82,"phoneExt":34,"email":83},"Alexandra Arvaji","0432530131","alexandra.arvaji@usz.ch",{"type":50,"investigatorFullName":85,"investigatorTitle":86,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"Christian Clarenbach","PD Dr. med Head of Pneumology","100451830","the-acute-cardiorespiratory-response-to-blood-flow-restricted-versus-traditional-exercise-training-regimens-care-bfr-100451830",false,"NCT05163600","The Acute Cardiorespiratory Response to Blood-flow Restricted Versus Traditional Exercise Training Regimens (CaRe BFR)","The Acute Cardiorespiratory Response to Blood-flow Restricted Versus Traditional Exercise Training Regimens (CaRe BFR):4 Randomized Crossover Studies","CaRe-BFR","Inclusion and exclusion for the healthy participants are defined by the following criteria.\n\nInclusion criteria:\n\n* Age ≥ 18 years\n* Clinically healthy\n\nExclusion criteria:\n\n* Physical or intellectual impairment precluding informed consent or protocol adherence\n* Non-German speaking (precluding informed consent)\n* Pain during exercise of any origin\n* Pregnancy\n* History of thromboembolic event in the lower extremity\n* Resting systolic blood pressure \\\u003C100 mmHg\n\nInclusion and exclusion for the COPD participants are defined by the following criteria.\n\nInclusion criteria:\n\n* Age ≥ 18 years\n* Diagnosed COPD according to GOLD-guidelines12\n\nExclusion criteria:\n\n* Physical or intellectual impairment precluding informed consent or protocol adherence\n* Non-German speaking (precluding informed consent)\n* Acute or recent (within the last 6 weeks) exacerbation of COPD\n* Pain during exercise of any origin\n* Pregnancy\n* History of thromboembolic event in the lower extremity\n* Resting systolic blood pressure \\\u003C100 mmHg",true,"ALL","18 Years","90 Years",{"count":100,"type":101},24,"ESTIMATED","INTERVENTIONAL",[104],"NA","The investigators hypothesize that BFR exercise regimens result in a different acute cardiorespiratory response pattern compared to traditional exercise regimens. Furthermore, the investigators hypothesize that these patterns differ between healthy participants and participants with COPD.\n\nRegarding secondary objective, the investigators hypothesize that BFR results in lower blood pressure responses compared to traditional exercise training in both healthy and COPD participants.",[107],"COPD","2026-07-03",{"date":110,"type":111},"2026-07-07","ACTUAL",{"date":113,"type":111},"2022-05-20",{"date":115,"type":101},"2026-12-31",{"name":5,"class":6},1]