[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651071":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":34,"locations":44,"responsibleParty":77,"collaborators":81,"id":84,"slug":85,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":93,"minAge":94,"maxAge":26,"enrollmentInfo":95,"targetDuration":26,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":109,"overallStatus":127,"whyStopped":26,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":137},{"fullName":5,"class":6},"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"BASIC-S Intervention Group","EXPERIMENTAL","Households allocated to this arm receive a multicomponent behavioral lifestyle program grounded in the Information-Motivation-Behavioral Skills (IMB) model.",[13],"Behavioral: BASIC-S Intervention",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard Care (Usual Care) Group","ACTIVE_COMPARATOR","Households allocated to this arm receive pure usual care to serve as a real-world comparator, continuing their routine healthcare and access to institutional wellness resources.",[19],"Behavioral: Standard \u002F Usual Care",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","BASIC-S Intervention","Participants attend an initial 45-minute goal-setting session with a certified wellness coach. Subsequent support includes an interactive BASIC-S Digital Workbook, automated twice-weekly motivational and educational SMS messages via Twilio, and biweekly (every two weeks) 15-20 minute face-to-face secure video booster sessions (via Microsoft Teams) using motivational interviewing. Intervention households receive a validated automated home blood pressure monitor at baseline.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Standard \u002F Usual Care","Participants are instructed to continue routine medical follow-up as directed by their primary care providers. To serve as a true comparator, no study-specific behavioral prompts or educational materials are provided during the active 6-month study period. To maximize ethical benefit (waitlist control), control households receive the complete BASIC-S Digital Workbook and a validated automated home blood pressure monitor at the conclusion of their 6-month follow-up visit.",[15],[32,33],"Waitlist","Control",[35,41],{"name":36,"role":37,"phone":38,"phoneExt":39,"email":40},"Andrew J Appleton, MD, FRCPC.","CONTACT","519-685-8500","33071","andrew.appleton@lhsc.on.ca",{"name":42,"role":37,"phone":26,"phoneExt":26,"email":43},"Abolfazl Avan, MD, PhD.","aavan2@uwo.ca",[45],{"facility":46,"status":26,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"London Health Sciences Centre (LHSC)","London","Ontario","N6A 3K7","Canada","CA",{"type":53,"coordinates":54},"Point",[55,56],-81.23304,42.98339,{"lat":56,"lon":55},[59,60,63,66,67,69,71,73,75],{"name":26,"role":37,"phone":38,"phoneExt":39,"email":40},{"name":61,"role":62,"phone":26,"phoneExt":26,"email":26},"Andrew J Appleton, MD.","PRINCIPAL_INVESTIGATOR",{"name":64,"role":65,"phone":26,"phoneExt":26,"email":26},"Vladimir Hachinski, MD, DSc","SUB_INVESTIGATOR",{"name":42,"role":65,"phone":26,"phoneExt":26,"email":26},{"name":68,"role":65,"phone":26,"phoneExt":26,"email":26},"George K Dresser, MD, PhD.",{"name":70,"role":65,"phone":26,"phoneExt":26,"email":26},"William A Fisher, PhD",{"name":72,"role":65,"phone":26,"phoneExt":26,"email":26},"Jamie A Seabrook, PhD",{"name":74,"role":65,"phone":26,"phoneExt":26,"email":26},"Guangyong Zou, PhD",{"name":76,"role":65,"phone":26,"phoneExt":26,"email":26},"Shawn N Whitehead, PhD",{"type":78,"investigatorFullName":79,"investigatorTitle":80,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Andrew Appleton","Dr",[82],{"name":83,"class":6},"Academic Medical Organization of Southwestern Ontario","100651071","the-basic-s-feasibility-study-for-vascular-risk-reduction-100651071",false,"NCT07755631","The BASIC-S Feasibility Study for Vascular Risk Reduction","Piloting an Integrated Lifestyle Intervention for Vascular Risk Reduction: The BASIC-S Feasibility Study","BASIC-S","Inclusion Criteria:\n\n* Adults aged 18 years and older currently employed at or recently retired from the London Health Sciences Centre (LHSC) or Western University (with an operational focus on pre-retirees aged 50 years and older).\n* The primary applicant (not their partner, if applicable) must be within two years before or after their retirement date.\n* Spouse or cohabitating partner of an enrolled primary participant. Cohabitating partners may include a common-law partner, adult child, close friend, or roommate who lives with the primary participant and shares common health goals. Enrollment of partners is optional but strongly encouraged.\n* Capable of providing informed consent.\n* Has access to a mobile device capable of receiving Short Message Service (SMS) communications and viewing PDF documents.\n* Physically able to safely engage in light-to-moderate intensity physical activity.\n\nExclusion Criteria:\n\n* Medical conditions that preclude safe participation in physical activity (for instance, unstable angina, uncontrolled arrhythmia, severe heart failure) without physician clearance.\n* Active or unstable psychiatric illness, defined as hospitalization for psychiatric care within the preceding 6 months or modifications to antipsychotic or mood-stabilizing pharmacotherapy within the preceding 3 months. Participants with stable, medically managed psychiatric conditions remain eligible.\n* Severe cognitive impairment that compromises the ability to provide informed consent or independently use study-related technology.\n* Inability to read and understand English sufficiently to provide informed consent and complete study procedures.",true,"ALL","18 Years",{"count":96,"type":97},120,"ESTIMATED","INTERVENTIONAL",[100],"NA","Vascular risk factors drive stroke, heart disease, and dementia, but translating lifestyle guidelines into routine clinical care remains challenging. To address this, we developed the BASIC-S framework, targeting Blood pressure, Activity, Sleep, Interaction (socially), Consumption (nutrition), and Support using partner support and motivational interviewing. This individual-focused approach bypasses the logistical and financial barriers of complex clinical interventions by using sustained behavioral science to support gradual lifestyle changes. This study is a single-center, mixed-methods, cluster-randomized pilot trial evaluating the feasibility of the BASIC-S protocol in an occupational setting. A maximum of 60 households (120 participants) will be randomized 1:1 to either the BASIC-S intervention (motivational coaching, secure video check-ins, automated text messages, and a digital workbook) or standard care. Outcomes will assess feasibility, acceptability, and the validity of new tracking metrics to inform a future full-scale trial.",[103,104,105,106,107,108],"Hypertension (HTN)","Vascular Diseases","Stroke","Dementia","Cardiovascular Risk Factor","Cognitive Decline",[110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126],"Lifestyle Intervention","Motivational Interviewing","Primary Prevention","Behavioral Medicine","Brain Health","Cognition","Mental Health","Social Activity","Social Isolation","Physical Activity","Blood Pressure","Activity","Sleep","Interaction","Consumption","Support","Partnering","NOT_YET_RECRUITING","2026-08-18",{"date":130,"type":131},"2026-08-19","ACTUAL",{"date":133,"type":97},"2026-10-01",{"date":135,"type":97},"2027-10-01",{"name":79,"class":6},1]