[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100386468":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":66,"collaborators":10,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":10,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":10,"studyType":82,"phases":10,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":48,"whyStopped":10,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"National Institutes of Health Clinical Center (CC)","NIH",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Arm 1",null,"46 healthy young (18-35) volunteers",{"label":13,"type":10,"description":14,"interventionNames":10},"Arm 2","46 healthy older (50-80) volunteers",{"label":16,"type":10,"description":17,"interventionNames":18},"Arm 3","46 chronic (\\>6 months post-stroke) stroke patients",[19,20],"Device: MRI system","Device: MEG system",[22,27],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"DEVICE","MRI system","MRI system - GE Discovery MR750 3T",[16],{"type":23,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"MEG system","MEG system The CTF MEG 275 Magnetoencephalography (MEG) scanner system",[16],[32],{"name":33,"affiliation":34,"role":35},"Leonardo G Cohen, M.D.","National Institute of Neurological Disorders and Stroke (NINDS)","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":10,"email":41},"Tasneem F Malik, C.R.N.P.","CONTACT","(301) 496-4000","tasneem.malik@nih.gov",{"name":33,"role":39,"phone":43,"phoneExt":10,"email":44},"(301) 496-9782","cohenl1@mail.nih.gov",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"National Institutes of Health Clinical Center","RECRUITING","Bethesda","Maryland","20892","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-77.10026,38.98067,{"lat":58,"lon":57},[61],{"name":62,"role":39,"phone":63,"phoneExt":64,"email":65},"For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)","800-411-1222","TTY8664111010","prpl@cc.nih.gov",{"type":67,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100386468","the-beneficial-effects-of-naps-on-motor-learning-100386468",false,"NCT04312126","The Beneficial Effects of Naps on Motor Learning","Mechanisms Underlying the Beneficial Effects of Naps on Motor Learning","* HEALTHY VOLUNTEERS:\n\nINCLUSION CRITERIA:\n\n* Age 18-35 (Arm 1) or 50-80 (Arms 2).\n* English speaking.\n* Clear right-hand dominance (\\>74 on Edinburgh Handedness Inventory).\n* Normal neurological examination as determined by the screening clinician.\n\nEXCLUSION CRITERIA:\n\n* HCPS affiliated NIH staff (i.e. - staff from our section).\n* Current pregnancy.\n* Contraindications for MRI or MEG.\n* Use of sleep medications within 24 hours of Experimental Session participation.\n* Severe or progressive neurological, psychological or medical condition as determined by the screening clinician.\n\nSTROKE PATIENTS:\n\nINCLUSION CRITERIA:\n\n* Age 18 or older\n* Willing and able to provide consent\n* Experienced a stroke 6 months ago or more that affected at least one of the upper extremities at time of stroke diagnosis\n* Ability to perform the study task as assessed during physical examination\n* English-speaking\n\nEXCLUSION CRITERIA:\n\n* HCPS-affiliated NIH staff (i.e. - staff from our section).\n* Current pregnancy\n* History of large stroke lesions in brainstem or cerebellum as determined by screening clinician\n* Severe or progressive neurological disorder other than stroke (e.g., Parkinson s disease or multiple sclerosis) as determined by the screening clinician\n* Uncontrolled heart, lung, kidney, gastrointestinal, metabolic, psychiatric, sleep, or endocrine disorders as determined by the screening clinician\n* Contraindications for MRI or MEG.",true,"ALL","18 Years","80 Years",{"count":80,"type":81},199,"ESTIMATED","OBSERVATIONAL","Background:\n\nMemory consolidation is the process by which memories become stable, long-term representations in the brain. Consolidation of a motor skill is dependent upon sleep. Some research shows that daytime naps improve people s motor performance and memory retention. Researchers want to find out how daytime naps may contribute to learning and support consolidation of motor skill memories.\n\nObjective:\n\nTo learn the role of memory replay during wakeful rest and sleep (naps) in retaining a newly learned skill.\n\nEligibility:\n\nEnglish-speaking adults ages 18 and older with chronic stroke, or healthy, right-handed, English-speaking adults ages 18-35 and 50-80\n\nDesign:\n\nParticipants will be screened with:\n\n* medical history\n* neurological history\n* medicine review\n* medical exam\n* neurological exam.\n\nParticipants will have a magnetic resonance imaging (MRI) scan of the brain. For this, they will lie down in a scanner. The scanner makes loud noises, so they will wear earplugs. They will fill out an MRI screening form before each MRI.\n\nParticipants will also have magnetoencephalography (MEG). MEG maps brain activity. It does this by recording the magnetic fields produced by naturally occurring electrical currents in the brain. For MEG, participants will lie down in the MEG room. Their eye movements may be recorded by a video camera.\n\nParticipants will have behavior testing. They will practice typing random keys. Then they will repeatedly type a custom sequence that they see on a computer screen. Then they will take a 2-hour nap. Then they will type the same sequence again.\n\nParticipants will have no more than 4 visits at the NIH over 3 months. Visits will last 2-4 hours each.",[85],"Stroke",[87,88,89,90],"Motor Skill","Sleep","Neural Replay","Natural History","2026-08-15",{"date":93,"type":94},"2026-08-18","ACTUAL",{"date":96,"type":94},"2021-03-04",{"date":98,"type":81},"2027-08-01",{"name":34,"class":6},1]