[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648112":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":37,"responsibleParty":118,"collaborators":120,"id":126,"slug":127,"hasResults":128,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":134,"sex":135,"minAge":136,"maxAge":12,"enrollmentInfo":137,"targetDuration":12,"studyType":140,"phases":141,"briefSummary":143,"conditions":144,"keywords":148,"overallStatus":40,"whyStopped":12,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":163},{"fullName":5,"class":6},"Oxford University Clinical Research Unit Indonesia","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard Group","NO_INTERVENTION","Patients will be treated in accordance with current standards of care for acute respiratory tract infections without the use of CRP point of care testing (POCT).",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Implementation group","EXPERIMENTAL","Patients will be treated with usual care and with the addition of CRP point of care testing (POCT).",[18],"Diagnostic Test: Implementation group",[20],{"type":21,"name":14,"description":22,"armGroupLabels":23,"otherNames":12},"DIAGNOSTIC_TEST","Patients will be treated with usual care and with the addition of CRP point-of-care testing (POCT). The testing process will use the ACTIM CRP® test and comply with ISO 13485 and MDSAP 13845 quality management system standards and is CE-marked for in vitro diagnostic use.\n\nCRP testing will be conducted by a trained research assistant who will be assigned on-site at each primary health care. The CRP POCT results will be provided to the treating physician as additional information to support clinical decision-making. The decision to prescribe antibiotics will remain based on the clinical decisions.",[14],[25],{"name":26,"affiliation":27,"role":28},"Robert Sinto, MD, DPhil","Dr Cipto Mangunkusumo General Hospital","PRINCIPAL_INVESTIGATOR",[30,34],{"name":26,"role":31,"phone":32,"phoneExt":12,"email":33},"CONTACT","+622123599099","rsinto@oucru.org",{"name":35,"role":31,"phone":32,"phoneExt":12,"email":36},"Raph L Hamers, MD, PhD","rhamers@oucru.org",[38,56,63,72,81,90,99,108],{"facility":39,"status":40,"city":41,"state":12,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Cengkareng Public Health Center","RECRUITING","Jakarta","11730","Indonesia","ID",{"type":46,"coordinates":47},"Point",[48,49],106.84513,-6.21462,{"lat":49,"lon":48},[52,53],{"name":26,"role":31,"phone":32,"phoneExt":12,"email":33},{"name":54,"role":31,"phone":32,"phoneExt":12,"email":55},"Shafira Permata Radiani, SKM","sradiani@oucru.org",{"facility":57,"status":58,"city":41,"state":12,"zip":59,"country":43,"countryCode":44,"cosmosGeoPoint":60,"geoPoint":62,"contacts":12},"Kebayoran Lama Public Health Center","ENROLLING_BY_INVITATION","12240",{"type":46,"coordinates":61},[48,49],{"lat":49,"lon":48},{"facility":64,"status":40,"city":41,"state":12,"zip":65,"country":43,"countryCode":44,"cosmosGeoPoint":66,"geoPoint":68,"contacts":69},"Pulo Gadung Public Health Center","13220",{"type":46,"coordinates":67},[48,49],{"lat":49,"lon":48},[70,71],{"name":26,"role":31,"phone":32,"phoneExt":12,"email":33},{"name":54,"role":31,"phone":32,"phoneExt":12,"email":55},{"facility":73,"status":40,"city":41,"state":12,"zip":74,"country":43,"countryCode":44,"cosmosGeoPoint":75,"geoPoint":77,"contacts":78},"Jatinegara Public Health Center","13310",{"type":46,"coordinates":76},[48,49],{"lat":49,"lon":48},[79,80],{"name":26,"role":31,"phone":32,"phoneExt":12,"email":33},{"name":54,"role":31,"phone":32,"phoneExt":12,"email":55},{"facility":82,"status":40,"city":41,"state":12,"zip":83,"country":43,"countryCode":44,"cosmosGeoPoint":84,"geoPoint":86,"contacts":87},"Duren Sawit Public Health Center","13440",{"type":46,"coordinates":85},[48,49],{"lat":49,"lon":48},[88,89],{"name":26,"role":31,"phone":32,"phoneExt":12,"email":33},{"name":54,"role":31,"phone":32,"phoneExt":12,"email":55},{"facility":91,"status":40,"city":41,"state":12,"zip":92,"country":43,"countryCode":44,"cosmosGeoPoint":93,"geoPoint":95,"contacts":96},"Cakung Public Health Center","13930",{"type":46,"coordinates":94},[48,49],{"lat":49,"lon":48},[97,98],{"name":26,"role":31,"phone":32,"phoneExt":12,"email":33},{"name":54,"role":31,"phone":32,"phoneExt":12,"email":55},{"facility":100,"status":40,"city":41,"state":12,"zip":101,"country":43,"countryCode":44,"cosmosGeoPoint":102,"geoPoint":104,"contacts":105},"Cilincing Public Health Center","14120",{"type":46,"coordinates":103},[48,49],{"lat":49,"lon":48},[106,107],{"name":26,"role":31,"phone":32,"phoneExt":12,"email":33},{"name":54,"role":31,"phone":32,"phoneExt":12,"email":55},{"facility":109,"status":40,"city":41,"state":12,"zip":110,"country":43,"countryCode":44,"cosmosGeoPoint":111,"geoPoint":113,"contacts":114},"Koja Public Health Center","14260",{"type":46,"coordinates":112},[48,49],{"lat":49,"lon":48},[115,117],{"name":116,"role":31,"phone":32,"phoneExt":12,"email":33},"Robert Sinto",{"name":54,"role":31,"phone":32,"phoneExt":12,"email":55},{"type":28,"investigatorFullName":116,"investigatorTitle":119,"investigatorAffiliation":27,"oldNameTitle":12,"oldOrganization":12},"Principle Investigator",[121,122,124],{"name":27,"class":6},{"name":123,"class":6},"Fakultas Kedokteran Universitas Indonesia",{"name":125,"class":6},"Oxford University Clinical Research Unit, Vietnam","100648112","the-c-reactive-protein-crp-point-of-care-testing-poct-implementation-to-adult-patients-presenting-with-symptoms-of-the-acute-respiratory-tract-infection-arti-in-eight-primary-health-care-phc-in-jakarta-100648112",false,"NCT07717372","The C-reactive Protein (CRP) Point of Care Testing (POCT) Implementation to Adult Patients Presenting With Symptoms of the Acute Respiratory Tract Infection (ARTI) in Eight Primary Health Care (PHC) in Jakarta.","Implementation of C-reactive Protein Point of Care Testing to Improve Antibiotic Use in Respiratory Tract Infection in the Indonesian Primary Health Care","INA IMPACT-RTI","Inclusion Criteria:\n\n1. Adults aged ≥18 years.\n2. Presenting to the PHC site for the first consultation of the current episode of Acute-Respiratory Tract Infections (ARTI).\n3. Reporting at least one of the following symptoms or clinical signs within the past 5 days: cough, rhinitis (e.g., sneezing, nasal congestion, or runny nose), pharyngitis (e.g., sore throat), shortness of breath, wheezing, chest pain, abnormal lung sounds on auscultation.\n\nExclusion Criteria:\n\n1. Presenting with severe illness requiring referral to a higher-level healthcare facility (e.g., hospital).\n2. Having known immunosuppression or chronic conditions, including but not limited to: HIV infection; chronic liver disease; history of malignancy; long-term use of systemic corticosteroids or other immunosuppressive therapies, as assessed by the healthcare worker or study team.\n3. Having taken antibiotics prior to the visit to the primary health center.",true,"ALL","18 Years",{"count":138,"type":139},2544,"ESTIMATED","INTERVENTIONAL",[142],"NA","Antimicrobial resistance (AMR) has emerged as one of the most pressing global health challenges of the 21st century, particularly Indonesia is projected to be among the five nations globally with the highest percentage increase in antimicrobial consumption by 2030. Primary care settings represent the most critical implementation point for addressing inappropriate antibiotic use. ARTI constitutes the most common indication for antibiotic prescribing in primary care, yet much of this prescribing is inappropriate. The high frequency of inappropriate antibiotic prescribing for ARTI is particularly problematic because most of these infections are viral in nature and resolve spontaneously without antibiotic treatment. Studies across the Asia-Pacific region, including Indonesia, have documented antibiotic prescribing rates for upper respiratory tract infections ranging from 47% to 85%, indicating substantial overuse.\n\nC-reactive protein (CRP) point-of-care test (POCT) has emerged as a promising, evidence-based implementation to reduce inappropriate antibiotic prescribing for acute respiratory infections in a systematic review of studies conducted primarily in primary care settings of high- and middle-income countries. However, the efficacy and safety of CRP POCT implementation have not been evaluated in Indonesian primary care settings, where healthcare infrastructure, patient populations, test acceptability, and prescribing practices may differ significantly from countries where studies have been conducted.\n\nThis research will fill a critical evidence gap by providing the first rigorous evaluation of CRP POCT in the Indonesian context. The findings will directly inform Indonesia's National Strategy for AMR Standard and provide evidence-based guidance for scaling antimicrobial stewardship implementations across Indonesian PHC sites. Reducing inappropriate antibiotic prescribing by implementing CRP will contribute to reduce the development of antimicrobial resistance, unnecessary adverse effects, and healthcare costs.",[145,146,147],"Adults","Acute Respiratory Tract Infection","Antibiotic Prescriptions",[149,150,151,152,153],"antibiotics","Accute Respiratory Track Infections","primary health care","Antibiotic prescribing","C-reactive protein point of care testing","2026-07-16",{"date":156,"type":157},"2026-07-21","ACTUAL",{"date":159,"type":157},"2026-04-06",{"date":161,"type":139},"2026-10",{"name":5,"class":6},8]