[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100656843":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":22,"studyPopulation":13,"armGroups":23,"interventions":36,"overallOfficials":13,"centralContacts":41,"locations":51,"responsibleParty":106,"collaborators":13,"id":108,"slug":109,"hasResults":110,"nctId":111,"briefTitle":112,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":110,"sex":115,"minAge":116,"maxAge":117,"enrollmentInfo":118,"targetDuration":13,"studyType":121,"phases":122,"briefSummary":124,"conditions":125,"keywords":127,"overallStatus":84,"whyStopped":13,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":139},{"fullName":5,"class":6},"National Heart Centre Singapore","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Primary RCT Outcome","Proportion of participants demonstrating clinically meaningful improvement in cognitive function at 24 weeks, defined as a pre-specified increase in standardized cognitive test scores.","24 weeks",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":17,"primaryPurpose":18,"observationalModel":13,"timePerspective":13,"maskingInfo":19},"RANDOMIZED","PARALLEL","There are both cohorts: main (observational) and randomized controlled trial (RCT) cohort. Participants in the RCT cohort will be randomized to receive exercise and cognitive intervention (Group R1) or no exercise nor cognitive intervention (Group R2).","SUPPORTIVE_CARE",{"masking":20,"maskingDescription":21,"whoMasked":13},"NONE","After obtaining consent, patient's study arm will be revealed via sequentially numbered, opaque, sealed and stapled envelopes.","Cardiovascular disease (CVD) and cognitive impairment frequently coexist in aging populations and accelerate each other's deterioration through shared vascular and neurobiological pathways.\n\nPrimary objectives:\n\ni. To determine the prevalence and profile of cognitive impairment in patients with cardiovascular disease\n\nii. For the RCT, to compare the proportion of patients who demonstrate improvement in cognitive test scores by 24 weeks between intervention and usual care arms.\n\nSecondary objectives:\n\ni. To evaluate changes in neuropsychological domains (e.g. memory, processing speed), mental health, frailty, and quality of life over time.\n\nii. To study the association between cognitive status and cardiovascular treatment plan categories.",[24,28,33],{"label":25,"type":26,"description":27,"interventionNames":13},"Main (Observational) Cohort","NO_INTERVENTION","Required procedures during baseline visit:\n\ni. Blood pressure test ii. Biospecimen collection (Optional) iii. Musculoskeletal analysis iv. Memory test: MoCA and MMSE",{"label":29,"type":6,"description":30,"interventionNames":31},"Randomized Controlled Trial (RCT) R1 Cohort","Baseline:\n\n1. Cardiovascular measurements:-\n\n   * Blood pressure test\n   * Echocardiography\n   * Electrocardiography\n2. Biospecimen collection\n3. Six-minute walk test\n4. Musculoskeletal Analysis\n5. Cardiopulmonary exercise test (CPET) \u002F Treadmill test (TMX)\n6. Magnetic resonance imaging\n7. Neuropsychological assessment\n\nDuring Intervention:\n\n12 exercise sessions and 12 cognitive sessions\n\nPost-Intervention:\n\n1. Same procedures as Baseline except CPET \u002F TMX\n2. Post-intervention questionnaire\n3. Qualitative interview (Optional)",[32],"Other: Structured cognitive and cardiovascular interventions",{"label":34,"type":26,"description":35,"interventionNames":13},"Randomized Controlled Trial (RCT) R2 Cohort","Baseline:\n\n1. Cardiovascular measurements:-\n\n   * Blood pressure test\n   * Echocardiography\n   * Electrocardiography\n2. Biospecimen collection\n3. Six-minute walk test\n4. Musculoskeletal Analysis\n5. Cardiopulmonary exercise test (CPET) \u002F Treadmill test (TMX)\n6. Magnetic resonance imaging\n7. Neuropsychological assessment\n\nPost-Intervention:\n\n1. Same procedures as Baseline, except CPET \u002F TMX\n2. Post-intervention questionnaire",[37],{"type":6,"name":38,"description":39,"armGroupLabels":40,"otherNames":13},"Structured cognitive and cardiovascular interventions","The intervention arm (RCT R1 cohort) will receive a 24-week multi-component program combining cardiac rehabilitation instruction, cognitive stimulation via a hybrid hospital and home-based telehealth platform.",[29],[42,47],{"name":43,"role":44,"phone":45,"phoneExt":13,"email":46},"Angela S. Koh, MBBS","CONTACT","+6567048961","angela.koh.s.m@singhealth.com.sg",{"name":48,"role":44,"phone":49,"phoneExt":13,"email":50},"Mee Yin Wong, BSc","+6567042302","wong.mee.yin@nhcs.com.sg",[52,73,83,92],{"facility":53,"status":54,"city":55,"state":13,"zip":13,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Alexandra Hospital","NOT_YET_RECRUITING","Singapore","SG",{"type":58,"coordinates":59},"Point",[60,61],103.85007,1.28967,{"lat":61,"lon":60},[64,68,71],{"name":65,"role":44,"phone":66,"phoneExt":13,"email":67},"Laureen Yi Ting Wang, MBBS","+6569082222","laureen_yt_wang@nuhs.edu.sg",{"name":69,"role":44,"phone":13,"phoneExt":13,"email":70},"Cheryl Tan","Cheryl_TAN_PT@nuhs.edu.sg",{"name":65,"role":72,"phone":13,"phoneExt":13,"email":13},"PRINCIPAL_INVESTIGATOR",{"facility":74,"status":54,"city":55,"state":13,"zip":13,"country":55,"countryCode":56,"cosmosGeoPoint":75,"geoPoint":77,"contacts":78},"Khoo Teck Puat Hospital",{"type":58,"coordinates":76},[60,61],{"lat":61,"lon":60},[79],{"name":80,"role":44,"phone":81,"phoneExt":13,"email":82},"Siew Fei Yap, MBBS","+6565558000","yap.siew.fei@nhghealth.com.sg",{"facility":5,"status":84,"city":55,"state":13,"zip":13,"country":55,"countryCode":56,"cosmosGeoPoint":85,"geoPoint":87,"contacts":88},"RECRUITING",{"type":58,"coordinates":86},[60,61],{"lat":61,"lon":60},[89,90,91],{"name":43,"role":44,"phone":45,"phoneExt":13,"email":46},{"name":48,"role":44,"phone":49,"phoneExt":13,"email":50},{"name":43,"role":72,"phone":13,"phoneExt":13,"email":13},{"facility":93,"status":54,"city":55,"state":13,"zip":13,"country":55,"countryCode":56,"cosmosGeoPoint":94,"geoPoint":96,"contacts":97},"Sengkang General Hospital",{"type":58,"coordinates":95},[60,61],{"lat":61,"lon":60},[98,102],{"name":99,"role":44,"phone":100,"phoneExt":13,"email":101},"Chiw Yeh Lim, MBBS","+6569302566","lim.chiw.yeh@singhealth.com.sg",{"name":103,"role":44,"phone":104,"phoneExt":13,"email":105},"Margaret Sok Teng Tan","+6567042261","margaret.tan.s.t@singhealth.com.sg",{"type":107,"investigatorFullName":13,"investigatorTitle":13,"investigatorAffiliation":13,"oldNameTitle":13,"oldOrganization":13},"SPONSOR","100656843","the-cardiovascular-cognitive-health-initiative-100656843",false,"NCT07829380","The Cardiovascular-Cognitive Health Initiative","COGENT","Inclusion Criteria:\n\nMain Study:\n\n* Age ≥ 21 years.\n* Able and willing (or via legally acceptable representative, LAR, where appropriate) to provide informed consent.\n\nRCT Sub-Study (Mild cognitive impairment (MCI) arm):\n\n* Meets main study criteria.\n* Mild cognitive impairment defined by: (i) Montreal cognitive assessment (MoCA) \\\u003C26 but ≥21; and\u002For (ii) impairment in at least one domain on standardized neuropsychological testing and\u002For (iii) MMSE \\\u003C28 but ≥24.\n\nExclusion Criteria:\n\n* Neurodegenerative disorders or major psychiatric illnesses that substantially impair cognition.\n* Terminal illness or advanced major organ disease limiting participation with expected survival of less than 1 year.\n* Severe depression, anxiety, or stress where participation may be inappropriate.\n* Any condition which, in the investigator's opinion, would compromise safety or study integrity.\n\nNote: Pregnant and breast-feeding women may not take part in this study.","ALL","21 Years","99 Years",{"count":119,"type":120},5000,"ESTIMATED","INTERVENTIONAL",[123],"NA","This study aims to understand how memory and thinking abilities (cognition) are affected in patients with heart conditions, and to find out if early detection and interventions can improve health outcomes.",[126],"Cognitive Impairment",[128,129],"cognitive assessment","cardiovascular disease","2026-09-14",{"date":132,"type":133},"2026-09-21","ACTUAL",{"date":135,"type":133},"2026-08-04",{"date":137,"type":120},"2030-12",{"name":5,"class":6},4]