[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654348":3},{"organization":4,"outcomesModule":7,"designInfo":41,"detailedDescription":50,"studyPopulation":40,"armGroups":51,"interventions":71,"overallOfficials":40,"centralContacts":88,"locations":98,"responsibleParty":116,"collaborators":40,"id":118,"slug":119,"hasResults":120,"nctId":121,"briefTitle":122,"officialTitle":122,"acronym":40,"eligibilityCriteria":123,"healthyVolunteers":124,"sex":125,"minAge":126,"maxAge":127,"enrollmentInfo":128,"targetDuration":40,"studyType":131,"phases":132,"briefSummary":134,"conditions":135,"keywords":139,"overallStatus":101,"whyStopped":40,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":150},{"fullName":5,"class":6},"University of Electronic Science and Technology of China","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":24,"otherOutcomes":40},[9,13,17,20],{"measure":10,"description":11,"timeFrame":12},"Fixation time on different areas of interest (AOIs) in free viewing tasks","The total time spent viewing specific AOIs in free viewing tasks will be recorded","baseline: one week before the stimulation; post: immediately after the 30 min sham (earlobe) or taVNS (transaural vagal stimulation) stimulation.",{"measure":14,"description":15,"timeFrame":16},"Fixation counts on different AOIs in free viewing tasks","The number of fixations on specific AOIs during presentation of visual stimuli will be recorded","baseline: one week before the stimulation; post: immediately after the 30 min of sham or taVNS stimulation",{"measure":18,"description":19,"timeFrame":16},"Errors made in the stressful antisaccade task","The number of errors in the direction opposite to the required direction",{"measure":21,"description":22,"timeFrame":23},"Response time in the stressful antisaccade task","Time taken to make the first saccade towards the required direction","baseline: one week before the stimulation; post: immediately after the 30 min sham or taVNS stimulation",[25,29,32,36],{"measure":26,"description":27,"timeFrame":28},"Saliva oxytocin concentrations","Four saliva samples will be collected at different time points during the experiment and oxytocin concentrations measured by assay","T1: baseline; T2: immediately after the 30 min sham or taVNS stimulation; T3: 20 mins after the stimulation; T4: 30 mins after the stimulation.",{"measure":30,"description":31,"timeFrame":28},"Saliva vasopressin concentrations","Four saliva samples will be collected at different time points during the experiment and vasopressin concentrations measured by assay",{"measure":33,"description":34,"timeFrame":35},"State anxiety scores","Subjects will complete the State Anxiety Questionnaire before and after stimulation","baseline: before the stimulation post: immediately after the 30 min sham or taVNS stimulation",{"measure":37,"description":38,"timeFrame":39},"Positive and negative affective schedule (PANAS) scores","Subjects will complete the PANAS questionnaire before and after stimulation","baseline: before the stimulation; post: immediately after the 30 min sham or taVNS stimulation.",null,{"allocation":42,"interventionModel":43,"interventionModelDescription":44,"primaryPurpose":45,"observationalModel":40,"timePerspective":40,"maskingInfo":46},"RANDOMIZED","PARALLEL","Parallel group design with a subsequent crossover phase for all participants","BASIC_SCIENCE",{"masking":47,"maskingDescription":40,"whoMasked":48},"SINGLE",[49],"PARTICIPANT","In a placebo-controlled, single-blind, mixed-design experiment, investigators plan to determine whether taVNS modulates human social attention and whether such effects depend on oxytocin (OT) modulation.\n\nParticipants will first complete free-viewing and stressful tasks to establish baseline social attention. Consistent with prior studies, participants whose baseline data exceed ±3 SD will be excluded from the study. One week later, eligible participants will complete the Chinese-language versions of several questionnaires prior to intervention: the Behavioral Activation System Scale (BAS), Behavioral Inhibition System Scale (BIS), Trait Anxiety Inventory, State Anxiety Inventory (STAI), Liebowitz Social Anxiety Scale (LSAS), Beck Depression Inventory (BDI), Autism Spectrum Quotient (AQ), Positive and Negative Affect Schedule (PANAS), and Interpersonal Reactivity Index (IRI).\n\nNext, the first saliva sample (T1: 1-2 mL, passive drool) will be collected, followed by 30-min non-invasive taVNS (left, right, or bilateral tragus) or sham (earlobe) intervention. A second saliva sample (T2) will be obtained immediately post-stimulation. Behavioral assessments - including free-viewing paradigms of social and non-social stimuli and a stressful antisaccade paradigm - will begin after T2 collection. Social-attention metrics (response time, errors, fixation duration, fixation counts, etc.) will be recorded using eye-tracking equipment.\n\nUpon completion of the eye-tracking tasks, the third saliva sample (T3: \\~20 min post-stimulation) will be collected. Participants will then repeat the State Anxiety and PANAS (mood) questionnaires to evaluate intervention-related changes in anxiety and mood. A fourth saliva sample (T4: \\~30 min post-stimulation) will subsequently be obtained.\n\nA mixed-linear model or mixed-model ANOVA, followed by appropriate post-hoc analyses, will be applied to eye-tracking behavioural data and questionnaires scores to evaluate intervention effects.\n\nInvestigators hypothesize that taVNS will increase social attention and oxytocin release, that social attention changes will be associated with the magnitude of oxytocin release and that bilateral tragus stimulation will be the most effective",[52,58,63,67],{"label":53,"type":54,"description":55,"interventionNames":56},"Experimental: earlobe stimulation","PLACEBO_COMPARATOR","Subjects will receive bilateral ear lobe stimulation as a control for taVNS",[57],"Device: taVNS",{"label":59,"type":60,"description":61,"interventionNames":62},"left tragus stimulation","EXPERIMENTAL","Subjects will receive the taVNS only on the left tragus",[57],{"label":64,"type":60,"description":65,"interventionNames":66},"right tragus stimulation","Subjects will receive the right tragus stimuliation",[57],{"label":68,"type":60,"description":69,"interventionNames":70},"bilateral tragus stimulation","Subjects will receive bilateral tragus stimulation",[57],[72,77,82,85],{"type":73,"name":74,"description":75,"armGroupLabels":76,"otherNames":40},"DEVICE","taVNS","bilateral Transcutaneous Auricular Vagus Nerve Stimulation on earlobe",[53],{"type":73,"name":74,"description":78,"armGroupLabels":79,"otherNames":80},"Transcutaneous Auricular Vagus Nerve Stimulation on left tragus",[59],[81],"Transcutaneous Auricular Vagus Nerve Stimulation",{"type":73,"name":74,"description":83,"armGroupLabels":84,"otherNames":40},"taVNS only on the right tragus",[64],{"type":73,"name":74,"description":86,"armGroupLabels":87,"otherNames":40},"taVNS on the bilateral tragus",[68],[89,94],{"name":90,"role":91,"phone":92,"phoneExt":40,"email":93},"Keith M Kendrick PhD","CONTACT","86-28-61830811","k.kendrick.uestc@gmail.com",{"name":95,"role":91,"phone":96,"phoneExt":40,"email":97},"yan zhang","18215678419","532769737@qq.com",[99],{"facility":100,"status":101,"city":102,"state":103,"zip":104,"country":105,"countryCode":106,"cosmosGeoPoint":107,"geoPoint":112,"contacts":113},"School of Life science and Technology, University of Electronic Science and Technology of China","RECRUITING","Chengdu","Sichuan","610081","China","CN",{"type":108,"coordinates":109},"Point",[110,111],104.06667,30.66667,{"lat":111,"lon":110},[114],{"name":115,"role":91,"phone":96,"phoneExt":40,"email":97},"Yan Zhang",{"type":117,"investigatorFullName":40,"investigatorTitle":40,"investigatorAffiliation":40,"oldNameTitle":40,"oldOrganization":40},"SPONSOR","100654348","the-effect-and-mechanism-of-tavns-in-modulating-human-social-attention-100654348",false,"NCT07798349","The Effect and Mechanism of taVNS in Modulating Human Social Attention","Inclusion Criteria:\n\nHealthy adults\n\nExclusion Criteria:\n\n* History of past or current neurological\u002Fpsychiatric disorders;\n* Use of psychotropic medications (including nicotine and alcohol)\n* Visual impairments\n* Baseline data exceeds ±3 SD from mean",true,"ALL","18 Years","30 Years",{"count":129,"type":130},120,"ESTIMATED","INTERVENTIONAL",[133],"NA","The objectives of this study are to investigate:\n\n1. whether non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) can enhance human interest in social stimuli in free-viewing and stressful tasks;\n2. whether its effect on brain function occurs via modulating endogenous oxytocin release;\n3. how the stimulation site and various parameters of taVNS should be set to effectively promote the above-mentioned changes in brain function.\n\nThe main questions it aims to answer are:\n\n1. Does taVNS facilitate a preference for social relative to non-social stimuli in both free-viewing and stressful tasks?\n2. Does taVNS increase peripheral concentrations of the neuropeptide oxytocin, and whether these changes are associated with enhanced social attention?\n3. Does taVNS stimulation of the right tragus, left tragus, or bilateral tragus sites produce the strongest effects on oxytocin release and social attention?\n\nInvestigators will compare the effects of taVNS targeting the left tragus, right tragus, or bilateral tragus with ear-lobe sham stimulation (no vagal activation). Eye-tracking will be used across multiple experimental paradigns. For measurements of oxytocin (OT) and arginine vasopressin (AVP), saliva samples will be collected at baseline, immediately after taVNS, 20 min post-stimulation, and 30 min post-stimulation. Investigators will test whether (a) taVNS facilitates social attention, and (b) its effects are associated with elevated OT and AVP release.\n\nInvestigators hypothesize that taVNS will enhance social attention and oxytocin release, that changes in social attention will be associated with the magnitude of oxytocin release, and that bilateral tragus stimulation will produce the strongest effects on both social attention and oxytocin release.",[136,137,138],"Healthy Adult","Role of Vagal Stimulation in Oxytocin Release","Role of Vagal Stimulation in Social Attention",[74,140],"social attention","2026-08-27",{"date":143,"type":144},"2026-09-01","ACTUAL",{"date":146,"type":144},"2026-08-01",{"date":148,"type":130},"2026-11-30",{"name":5,"class":6},1]