[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620443":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":24,"centralContacts":34,"locations":44,"responsibleParty":66,"collaborators":24,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":24,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":24,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":98,"whyStopped":24,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Chengdu University of Traditional Chinese Medicine","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Verum acupuncture group (VA)","EXPERIMENTAL","Acupoint with acupuncture treatment",[13],"Other: Acupuncture",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham acupuncture group (SA)","SHAM_COMPARATOR","Non-acupoint with sham acupuncture treatment",[19],"Other: Sham acupuncture",{"label":21,"type":22,"description":23,"interventionNames":24},"Waitlist control group","NO_INTERVENTION","Acupoint with acupuncture treatment after 8-week waiting period",null,[26,30],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":24},"Acupuncture","Participants will be alternatively acupunctured on two set of acupoints . The first set of acupuncture points incudes Baihui (GV20), bilateral Shenmen (HT7), bilateral Neiguan (PC6), Qihai (CV6), Guanyuan (CV4), bilateral Zusanli (ST36), bilateral Sanyinjiao (SP6). The second set of acupoints consist of Sishenchong (EX-HN1), bilateral Ganshu (BL18), bilateral Pishu (BL20), bilateral Shenshu (BL23), bilateral Taixi (KI3).The treatment consists of 24 sessions of 30 minutes, given within eight weeks (three sessions per week). A set of acupoints is acupunctured each treatment session.",[9],{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":24},"Sham acupuncture","Nonpenetrating acupuncture on non-acupoints will be performed using Park sham acupuncture device (0.25 mm in diameter and 40 mm in length, Hwatuo, Suzhou, China) for participants. Two sets of non-acupoints will be alternatively acupunctured. The first set of sham acupoints includes bilateral non-acupoint 1, bilateral non-acupoint 2, non-acupoint 3, non-acupoint 4, bilateral non-acupoint 5, bilateral non-acupoint 6. The second set consists of bilateral non-acupoint 7, bilateral non-acupoint 8, bilateral non-acupoint 9, bilateral non-acupoint 10. The treatment consists of 24 sessions of 30 minutes, given within eight weeks (three sessions per week). A set of non-acupoints will be acupunctured each treatment session.",[15],[35,40],{"name":36,"role":37,"phone":38,"phoneExt":24,"email":39},"Tingting Luo","CONTACT","+86-18782007605","1970001905@qq.com",{"name":41,"role":37,"phone":42,"phoneExt":24,"email":43},"Yi An","+86-18140244562","rose3719@163.com",[45,62],{"facility":5,"status":24,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Chengdu","Sichuan","611130","China","CN",{"type":52,"coordinates":53},"Point",[54,55],104.06667,30.66667,{"lat":55,"lon":54},[58],{"name":59,"role":37,"phone":60,"phoneExt":24,"email":61},"Xi Wu","+86-18008020710","wuxi@cdutcm.edu.cn",{"facility":5,"status":24,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":63,"geoPoint":65,"contacts":24},{"type":52,"coordinates":64},[54,55],{"lat":55,"lon":54},{"type":67,"investigatorFullName":59,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"SPONSOR_INVESTIGATOR","Professor","100620443","the-effect-of-acupuncture-therapy-on-cognitive-function-in-post-covid-19-myalgic-encephalomyelitischronic-fatigue-syndrome-100620443",false,"NCT07357688","The Effect of Acupuncture Therapy on Cognitive Function in Post-COVID-19 Myalgic Encephalomyelitis\u002FChronic Fatigue Syndrome","The Effect of Acupuncture Therapy on Cognitive Function in Post-COVID-19 Myalgic Encephalomyelitis\u002FChronic Fatigue Syndrome: A Study With Multimodal Magnetic Resonance Imaging","Inclusion Criteria:\n\n* 18-60 years old\n* Fatigue occurred during or after initial recovery of COVID-19 confirmed by nasopharyngeal swab reverse transcription-polymerase chain reaction(RT-PCR) or antigen testing lasts for at least 6 months\n* Fulfilling US National Academy of Medicine(NAM) criteria for ME\u002FCFS\n* Chinese native speaker\n* Right handedness\n* Voluntary to participate in the study and signing the informed consent form.\n\nExclusion Criteria:\n\n* Persistent fatigue occurs prior to COVID-19\n* Previous or current diagnosis of severe chronic diseases such as heart, kidney or liver failure, tumor\n* Previous or current diagnosis of neurological or psychiatric disorder such as neurodegenerative disease, stroke, epilepsy, bipolar disorder, schizophrenia\n* Previous or current diagnosis of endocrine or metabolic disease such as hypothyroidism, adrenocortical hypofunction, type 2 diabetes\n* Previous or current diagnosis of autoimmune disease such as systemic lupus erythematosus, Sjögren's syndrome, rheumatoid arthritis\n* Chronic infection or inflammatory disease such as acquired immune deficiency syndrome(AIDS), chronic hepatitis, irritable bowel syndrome\n* Substance or alcohol abuse\n* Obesity (Body Mass Index≥28)\n* Long-term use of immunosuppressant or glucocorticoid\n* Within one year after major surgery\n* Metal or electronic device implants\n* Claustrophobia\n* Pregnancy or lactation\n* Previous acupuncture treatment in the latest 3 months\n* Participating in another clinical research within a month",true,"ALL","18 Years","60 Years",{"count":81,"type":82},99,"ESTIMATED","INTERVENTIONAL",[85],"NA","Background of study:\n\nMyalgic encephalomyelitis\u002Fchronic fatigue syndrome (ME\u002FCFS) is a common sequela after SARS-CoV-2 infection(COVID-19). Cognitive dysfunction is one of the most common debilitating symptoms in ME\u002FCFS. Currently, standardized therapy for ME\u002FCFS has not been established. Some treatments, such as cognitive behavioral therapy (CBT) and graded exercise therapy (GET), mainly exert effects on physical symptoms, whereas the influence on cognitive problems is not significant. Acupuncture is an important complementary and alternative therapy for ME\u002FCFS. However, However, research focused on the impact of acupuncture on cognitive functions in ME\u002FCFS is rare. Additionally, no study has evaluated the efficacy and mechanism of acupuncture treatment in improving cognitive functions for post-COVID-19 ME\u002FCFS.\n\nObjective of the study:\n\nThe first objective of this study is to assess the efficacy of acupuncture treatment in improving cognitive function for post-COVID-19 ME\u002FCFS. The second objective is to explore whether acupuncture improves cognitive ability in patients with post-COVID-19 ME\u002FCFS through modulating hippocampal connectivity and metabolites using multimodal magnetic resonance imaging(MRI).\n\nStudy design:\n\nA prospective, three-armed, randomized controlled trial with resting-state functional MRI(rs-fMRI) and magnetic resonance spectroscopy(MRS). Adults with post-COVID-19 ME\u002FCFS will be randomly assigned to acupuncture, sham acupuncture, or waitlist control group in a 1:1:1 ratio, receiving 8-week intervention or waiting. Cognitive functions and resting-state functional connectivity(RSFC) and the levels of metabolites for each hippocampus will be examined at baseline and 8th week.\n\nStudy population:\n\nPatients fulfilling 2015 National Academy of Medicine (NAM) criteria for ME\u002FCFS following COVID-19.",[88],"Myalgic Encephalomyelitis\u002FChronic Fatigue Syndrome",[90,91,92,93,94,95,96,97],"Post-COVID-19","myalgic encephalomyelitis\u002Fchronic fatigue syndrome","hippocampus","cognitive function","neurochemical","functional connectivity","multimodal MRI","acupuncture","NOT_YET_RECRUITING","2026-01-13",{"date":101,"type":102},"2026-01-22","ACTUAL",{"date":104,"type":82},"2026-05",{"date":106,"type":82},"2027-12",{"name":59,"class":6},2]