[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654536":3},{"organization":4,"outcomesModule":7,"designInfo":28,"detailedDescription":27,"studyPopulation":27,"armGroups":36,"interventions":47,"overallOfficials":27,"centralContacts":52,"locations":58,"responsibleParty":75,"collaborators":27,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":27,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":87,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":27,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":27,"overallStatus":100,"whyStopped":27,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"University of Gaziantep","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":22,"otherOutcomes":27},[9,13,16,19],{"measure":10,"description":11,"timeFrame":12},"Salivary Irisin Level","Irisin concentration will be determined from a saliva sample using the ELISA technique.","Baseline- immediately after exercise and 1 hours after exercise",{"measure":14,"description":15,"timeFrame":12},"Salivary Klotho Level","Klotho concentration will be determined from a saliva sample using the ELISA technique.",{"measure":17,"description":18,"timeFrame":12},"Salivary Sirtuin Level","Sirtuin concentration will be determined from a saliva sample using the ELISA technique.",{"measure":20,"description":21,"timeFrame":12},"Salivary BDNF Level","BDNF concentration will be determined from a saliva sample using the ELISA technique.",[23],{"measure":24,"description":25,"timeFrame":26},"Saliva Flow Rate","It will be calculated individually by dividing the weight of the saliva collected within one minute by the duration.","Baseline- İmmediately after exercise and 1 hour after exercise",null,{"allocation":29,"interventionModel":30,"interventionModelDescription":27,"primaryPurpose":31,"observationalModel":27,"timePerspective":27,"maskingInfo":32},"RANDOMIZED","PARALLEL","BASIC_SCIENCE",{"masking":33,"maskingDescription":27,"whoMasked":34},"SINGLE",[35],"PARTICIPANT",[37,43],{"label":38,"type":39,"description":40,"interventionNames":41},"Experimental Group","EXPERIMENTAL","Aerobic exercise",[42],"Behavioral: Aerobic exercise",{"label":44,"type":45,"description":46,"interventionNames":27},"Control Group","NO_INTERVENTION","No exercise",[48],{"type":49,"name":40,"description":50,"armGroupLabels":51,"otherNames":27},"BEHAVIORAL","Acute aerobic exercise until exhaustion",[38],[53],{"name":54,"role":55,"phone":56,"phoneExt":27,"email":57},"Cemre Didem Eyipınar, PhD","CONTACT","+90 545 264 54 86","cemreeyipinar@gantep.edu.tr",[59],{"facility":60,"status":27,"city":61,"state":62,"zip":63,"country":64,"countryCode":27,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"Gaziantep University Faculty of Sports Sciences","Gaziantep","Sehitkamil","85142","Turkey (Türkiye)",{"type":66,"coordinates":67},"Point",[68,69],37.3825,37.05944,{"lat":69,"lon":68},[72],{"name":73,"role":55,"phone":74,"phoneExt":27,"email":57},"CEMRE","05452645486",{"type":76,"investigatorFullName":77,"investigatorTitle":78,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"SPONSOR_INVESTIGATOR","Cemre Didem Eyipinar","Research Assistant","100654536","the-effect-of-aerobic-exercise-on-the-irisinklothosirtuin-1bdnf-axis-100654536",false,"NCT07800156","The Effect of Aerobic Exercise on the Irisin\u002FKlotho\u002FSirtuin-1\u002FBDNF Axis","The Effect of Aerobic Exercise on the Irisin\u002FKlotho\u002FSirtuin-1\u002FBDNF Axis: A Randomized Controlled Study","Inclusion Criteria:\n\n* Being between the ages of 18 and 45\n* Being in good health and having no diagnosis of any chronic disease\n* Not having taken regular medication within the last 4 weeks\n* Voluntary participation and providing written informed consent\n\nExclusion Criteria:\n\n* Individuals with a history of cardiovascular, endocrine, metabolic, or renal disease\n* Individuals with a history of active infection, musculoskeletal injury, or severe disability\n* Individuals with any medical condition that might prevent participation in exercise\n* Individuals unable to regularly participate in the exercise protocol throughout the study",true,"MALE","18 Years","45 Years",{"count":91,"type":92},26,"ESTIMATED","INTERVENTIONAL",[95],"NA","The purpose of this study is to investigate the effects of an acute aerobic exercise on irisin, klotho, sirtuin-1, and BDNF levels in the healthy adults. The findings will help understand the physiological impacts of exercise on these biomarkers.",[98,99],"Healthy Adult","Athlete","NOT_YET_RECRUITING","2026-08-28",{"date":103,"type":104},"2026-09-02","ACTUAL",{"date":103,"type":92},{"date":107,"type":92},"2027-05-02",{"name":77,"class":6},1]