[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650214":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":11,"centralContacts":38,"locations":44,"responsibleParty":56,"collaborators":11,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":11,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":11,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":11,"overallStatus":80,"whyStopped":11,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"The Hong Kong Polytechnic University","OTHER",[8,15,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Active tDCS and aerobic exercise","ACTIVE_COMPARATOR",null,[13,14],"Behavioral: Aerobic exercise","Device: Active tDCS",{"label":16,"type":17,"description":11,"interventionNames":18},"Sham tDCS and aerobic exercise","SHAM_COMPARATOR",[13,19],"Device: Sham tDCS",{"label":21,"type":22,"description":11,"interventionNames":11},"Waitlist control group","NO_INTERVENTION",[24,29,34],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"BEHAVIORAL","Aerobic exercise","Aerobic exercise training will be conducted twice per week, over a period of 6 weeks, supervised by a well-trained facilitator. Each 45-minute session consists of a warm-up (10 minutes), treadmill walking (15 minutes), stationary bike cycling (15 minutes), and cool-down stretching (5 minutes). Heart rate will be monitored throughout training by a wearable device, and 60% of the maximum heart rate (roughly calculated by 220-age) should be maintained for at least 20 minutes during each session. Participants may stop exercising at any time if they feel uncomfortable.",[9,16],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":11},"DEVICE","Active tDCS","Active tDCS will be applied using a wearable stimulator (Liftid) at a constant stimulation intensity of 1.2 mA for 20 minutes. The device has been designed for anodal stimulation targeting the dorsolateral prefrontal cortex (DLPFC) using the F3 (anode) to F4 (cathode) montages.",[9],{"type":30,"name":35,"description":36,"armGroupLabels":37,"otherNames":11},"Sham tDCS","Sham tDCS will be performed using the same device but without stimulation. During the aerobic exercise training, all participants will wear the device, and a facilitator will turn on the stimulation for participants receiving a-tDCS+AE intervention, and pretend to turn on the stimulation for participants receiving s-tDCS+AE intervention after the first 10-minute warm-up section.",[16],[39],{"name":40,"role":41,"phone":42,"phoneExt":11,"email":43},"Prof. Jessie LIN","CONTACT","+852 2766 6718","jx-jessie.lin@polyu.edu.hk",[45],{"facility":5,"status":11,"city":46,"state":47,"zip":11,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":11},"Hung Hom","Kowloon","Hong Kong","HK",{"type":51,"coordinates":52},"Point",[53,54],114.18532,22.30715,{"lat":54,"lon":53},{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","LIN Jingxia Jessie","Assistant Professor","100650214","the-effect-of-combined-brain-stimulation-and-exercise-for-improving-cognitive-function-in-schizophrenia-100650214",false,"NCT07745140","The Effect of Combined Brain Stimulation and Exercise for Improving Cognitive Function in Schizophrenia","Feasibility of an Integrative Treatment of Brain Stimulation and Exercise on Cognitive Function in Schizophrenia: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Schizophrenia spectrum disorders;\n* Aged from 18 to 65.\n* Chinese-speaking (to enable cognitive testing).\n* Ability to understand the nature of the study and to give informed consent.\n* Fewer than 10 hours of physical exercise in the previous 3 months.\n\nExclusion Criteria:\n\n* Severe physical illness (Myocardial Infarction, Hypertension, Fracture, Spinal problems in which exercise with mild-to-moderate intensity may be contraindicated).\n* Comorbid diagnoses of organic brain syndrome, substance misuse, history of epilepsy or seizure, intellectual disability, significant head trauma, active suicidal ideation or self-harm behaviors.\n* Known pregnancy, or other contraindication to tDCS or MRI (e.g., have a cardiac\u002Fheart pacemaker, brain aneurysm clips, any implanted metallic or electrical device, or any internal metal foreign objects).","ALL","18 Years","65 Years",{"count":71,"type":72},66,"ESTIMATED","INTERVENTIONAL",[75],"NA","The study will investigate the (1) additive and synergistic effects of tDCS and aerobic exercise on cognitive function and clinical symptoms in schizophrenia, and (2) neurophysiological mechanisms (mediators) underlying these effects.",[78,79],"Schizophrenia","Cognitive Functions","NOT_YET_RECRUITING","2026-07-30",{"date":83,"type":84},"2026-08-04","ACTUAL",{"date":86,"type":72},"2026-09-01",{"date":88,"type":72},"2028-12-31",{"name":5,"class":6},1]