[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100656678":3},{"organization":4,"outcomesModule":7,"designInfo":17,"detailedDescription":16,"studyPopulation":16,"armGroups":23,"interventions":36,"overallOfficials":45,"centralContacts":49,"locations":54,"responsibleParty":67,"collaborators":16,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":16,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":78,"maxAge":16,"enrollmentInfo":79,"targetDuration":16,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":16,"overallStatus":88,"whyStopped":16,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"University of California, San Francisco","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":16,"otherOutcomes":16},[9,13],{"measure":10,"description":11,"timeFrame":12},"Mean Glucose Concentration","Average glucose level recorded by continuous glucose monitor (CGM) across the exercise intervention block and its subsequent recovery window.","Measured continuously over each 5-day exercise\u002Frecovery block within the 11-day monitoring period.",{"measure":14,"description":15,"timeFrame":12},"Time in Range (TIR)","Percentage of time spent with sensor glucose values under 120mg\u002FdL during the active exercise block and its recovery window.",null,{"allocation":18,"interventionModel":19,"interventionModelDescription":16,"primaryPurpose":20,"observationalModel":16,"timePerspective":16,"maskingInfo":21},"RANDOMIZED","CROSSOVER","PREVENTION",{"masking":22,"maskingDescription":16,"whoMasked":16},"NONE",[24,30],{"label":25,"type":26,"description":27,"interventionNames":28},"Moderate Intensity Exercise","EXPERIMENTAL","Five consecutive days of moderate intensity aerobic exercise",[29],"Other: Moderate Intensity aerobic training",{"label":31,"type":32,"description":33,"interventionNames":34},"High Intensity Exercise","ACTIVE_COMPARATOR","One session High-Intensity Interval training",[35],"Other: High Intensity Interval Training",[37,41],{"type":6,"name":38,"description":39,"armGroupLabels":40,"otherNames":16},"High Intensity Interval Training","The Norwegian 4x4: The workout begins with a 5-to-10-minute warm-up, followed by four separate 4-minute high-intensity intervals where you push your body to 85%-95% of your maximum heart rate (roughly an 8 or 9 out of 10 effort level, where you are breathing too heavily to speak full sentences). Each intense \"push\" is interspersed with a 3-minute active recovery period of low-intensity movement-such as walking or light cycling-to let your heart rate drop back down to roughly 60%-70% of its maximum before starting the next round.",[31],{"type":6,"name":42,"description":43,"armGroupLabels":44,"otherNames":16},"Moderate Intensity aerobic training","45 minutes of zone 2 training for five consecutive days",[25],[46],{"name":47,"affiliation":5,"role":48},"Jeanne Noble, MD","PRINCIPAL_INVESTIGATOR",[50],{"name":47,"role":51,"phone":52,"phoneExt":16,"email":53},"CONTACT","5109676874","jeanne.noble@ucsf.edu",[55],{"facility":5,"status":16,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":16},"San Francisco","California","94143","United States","US",{"type":62,"coordinates":63},"Point",[64,65],-122.41942,37.77493,{"lat":65,"lon":64},{"type":68,"investigatorFullName":16,"investigatorTitle":16,"investigatorAffiliation":16,"oldNameTitle":16,"oldOrganization":16},"SPONSOR","100656678","the-effect-of-high-intensity-short-duration-exercise-versus-moderate-intensity-high-volume-exercise-on-glucose-control-100656678",false,"NCT07829042","The Effect of High-Intensity Short-Duration Exercise Versus Moderate-Intensity High-Volume Exercise on Glucose Control","The Effect of High-Intensity Short-Duration Exercise Versus Moderate-Intensity High-Volume Exercise on Glucose Control as Measured by Continuous Glucose Monitoring","Inclusion Criteria:\n\nAge 18 years or older Non-diabetic or pre-diabetic status (defined by medical history or standard screening criteria, e.g., HbA1c \\\u003C 6.5%) Capable and willing to participate in both Zone 2 aerobic exercise and high-intensity interval training (HIIT) protocols Willing to wear a continuous glucose monitor (Dexcom G7) continuously for the 11-day study duration Able to provide written informed consent\n\nExclusion Criteria:\n\nDiagnosis of Type 1 or Type 2 diabetes Use of glucose-lowering medications, insulin, or other pharmaceuticals that significantly alter glucose metabolism Current skin conditions, allergies, or sensitivities to medical-grade adhesives that prevent continuous glucose monitor placement Musculoskeletal, cardiovascular, or neurological conditions that contraindicate vigorous exercise or high-intensity interval training Pregnant or planning to become pregnant during the study period Concurrent participation in another clinical trial or interventional exercise study",true,"ALL","18 Years",{"count":80,"type":81},12,"ESTIMATED","INTERVENTIONAL",[84],"NA","This study will be conducted as a prospective, randomized crossover trial evaluating non-diabetic and pre-diabetic adults ($n=12$) continuously monitored with Dexcom G7 continuous glucose monitors over an 11-day period. Participants will complete two distinct exercise protocols in a randomized sequence: five consecutive days of Zone 2 aerobic exercise and a single session of high-intensity interval training (HIIT). Primary outcome metrics will focus on mean glucose levels and time in range (TIR, defined as $\\\\le 120\\\\text{ mg\u002FdL}$) recorded throughout each active exercise block and its associated recovery window. To evaluate the comparative efficacy of the two modalities, paired within-subject differences will be statistically analyzed against pre-specified non-inferiority margins set at $3\\\\text{ mg\u002FdL}$ for mean glucose, as well as a primary $3$-point and secondary $5$-point margin for time in range.",[87],"Glucose Control","NOT_YET_RECRUITING","2026-09-18",{"date":91,"type":92},"2026-09-22","ACTUAL",{"date":94,"type":81},"2026-09-15",{"date":96,"type":81},"2026-10-20",{"name":5,"class":6},1]