[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648930":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":54,"collaborators":25,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":25,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":81,"overallStatus":86,"whyStopped":25,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"University of Lausanne","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Sprint interval training group (SIT group)","EXPERIMENTAL","The model of sprint interval training (SIT) consists of four to six 30 s all-out cycling bouts on a cycle ergometer, with 4 min rests between tests. Three sessions will be performed per week for three weeks.",[13,14],"Dietary Supplement: Olive leaf extract","Dietary Supplement: Placebo",{"label":16,"type":10,"description":17,"interventionNames":18},"Moderate intensity continuous training (MICT group)","The moderate intensity continuous training (MICT) consists of 40 to 60 min cycling on a cycle ergometer at 50% of the maximal aerobic power output. Three sessions will be performed per week for three weeks.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Olive leaf extract","A capsule containing 250 mg of an olive leaf extract preparation will be swallowed with a glass of water daily for 21 days.",[16,9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Placebo","A capsule containing 336 mg of cellulose microcrystalline will be swallowed with a glass of water daily for 21 days.",[16,9],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Nicolas Place, PhD","CONTACT","+41216923806","nicolas.place@unil.ch",[37],{"facility":38,"status":25,"city":39,"state":25,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Bâtiment Synathlon, quartier UNIL-Centre","Lausanne","1015","Switzerland","CH",{"type":44,"coordinates":45},"Point",[46,47],6.63282,46.516,{"lat":47,"lon":46},[50,51],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},{"name":52,"role":53,"phone":25,"phoneExt":25,"email":25},"Javier Botella, PhD","SUB_INVESTIGATOR",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Nicolas Place","Prof.","100648930","the-effect-of-olive-leaf-extract-supplementation-on-training-induced-skeletal-muscle-functional-and-molecular-adaptations-in-healthy-volunteers-100648930",false,"NCT07729072","The Effect of Olive Leaf Extract Supplementation on Training-induced Skeletal Muscle Functional and Molecular Adaptations in Healthy Volunteers","OLE_Training_1","Inclusion Criteria:\n\n1. Being between 18 and 45 years old\n2. Being healthy (assessed through the PAR-Q questionnaire).\n3. Being physically active, but not involved in any structured training program\n4. Being available for the study period.\n\nExclusion Criteria:\n\n1. If a participant answers positively to any YES\u002FNO question in the PAR-Q health questionnaire. For questions requiring a precision, any positive answer will be reviewed by a medical doctor, who will determine the inclusion\u002Fexclusion of the participant.\n2. Having allergy to xylocaine\n3. Being pregnant.",true,"ALL","18 Years","45 Years",{"count":70,"type":71},60,"ESTIMATED","INTERVENTIONAL",[74],"NA","The goal of this study is to investigate the effect of combining olive leaf extract supplementation with endurance training (moderate intensity continuous training or sprint interval training). We hypothesize that OLE supplementation during training, as compared to training alone with placebo, will translate into better performance outcomes. More specifically, we hypothesize that the additional benefits of OLE supplementation on performance will be mediated by improved mitochondrial characteristics in skeletal muscle and increased neural activation.",[77,78,79,80],"Healthy Adult Participants","Exercise Training","Neuromuscular Adaptations","Nutritional Intervention",[82,83,84,85],"exercise","mitochondria","knee extensors","performance","NOT_YET_RECRUITING","2026-07-22",{"date":89,"type":90},"2026-07-27","ACTUAL",{"date":92,"type":71},"2026-09-01",{"date":94,"type":71},"2029-12-31",{"name":5,"class":6},1]