[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650362":3},{"organization":4,"armGroups":7,"interventions":31,"overallOfficials":50,"centralContacts":55,"locations":60,"responsibleParty":77,"collaborators":37,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":37,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":87,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":37,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":101,"overallStatus":106,"whyStopped":37,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Poznan University of Physical Education","OTHER",[8,15,21,26],{"label":9,"type":10,"description":11,"interventionNames":12},"CAF + BJ (Active Co-ingestion)","EXPERIMENTAL","Participants ingest a concentrated beetroot juice shot (\\~6.4 mmol \u002F 400 mg nitrates) 3 hours before exercise, and a capsule of caffeine (Cohort A: 6 mg\u002Fkg body mass; Cohort B: 3 mg\u002Fkg body mass) 60 minutes before exercise.",[13,14],"Dietary Supplement: Caffeine","Dietary Supplement: Dietary Nitrate (Beetroot Juice)",{"label":16,"type":17,"description":18,"interventionNames":19},"CAF + PLBJ (Caffeine + Placebo BJ)","ACTIVE_COMPARATOR","Participants ingest a nitrate-depleted beetroot juice shot (\\~0.04 mmol nitrates) 3 hours before exercise, and a capsule of caffeine (Cohort A: 6 mg\u002Fkg body mass; Cohort B: 3 mg\u002Fkg body mass) 60 minutes before exercise.",[13,20],"Dietary Supplement: Placebo (Nitrate-Depleted Beetroot Juice)",{"label":22,"type":17,"description":23,"interventionNames":24},"PLCAF + BJ (Placebo CAF + Beetroot Juice)","Participants ingest a concentrated beetroot juice shot (\\~6.4 mmol \u002F 400 mg nitrates) 3 hours before exercise, and a placebo capsule (maltodextrin) 60 minutes before exercise.",[14,25],"Dietary Supplement: Placebo (Maltodextrin Capsule)",{"label":27,"type":28,"description":29,"interventionNames":30},"PLCAF + PLBJ (Double Placebo Control)","PLACEBO_COMPARATOR","Participants ingest a nitrate-depleted beetroot juice shot (\\~0.04 mmol nitrates) 3 hours before exercise, and a placebo capsule (maltodextrin) 60 minutes before exercise.",[25,20],[32,38,42,46],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"DIETARY_SUPPLEMENT","Caffeine","Anhydrous caffeine administered orally in a hard gelatine capsule. To address the unique physiological profiles of the two cohorts, a highly specific, differentiated dosing protocol is implemented: Cohort A (adult functional fitness athletes) will receive a high-performance dose of 6 mg\u002Fkg body mass, while Cohort B (elite junior swimmers) will receive a safe, youth-adapted dose of 3 mg\u002Fkg body mass. In all experimental trials, the capsule is ingested exactly 60 minutes prior to the onset of the discipline-specific exercise test to match peak plasma caffeine concentration.",[9,16],null,{"type":33,"name":39,"description":40,"armGroupLabels":41,"otherNames":37},"Dietary Nitrate (Beetroot Juice)","Concentrated beetroot juice (BJ) administered as a single, acute organic shot of 70 mL (Beet It Sport, James White Drinks Ltd., Ipswich, UK). Each active shot contains approximately 400 mg (equivalent to \\~6.4 mmol) of inorganic nitrate. In contrast to chronic loading designs, this study evaluates purely acute effects; the shot is ingested exactly 3 hours (180 minutes) prior to the physical performance test to align with peak systemic concentration of plasma nitrite.",[9,22],{"type":33,"name":43,"description":44,"armGroupLabels":45,"otherNames":37},"Placebo (Maltodextrin Capsule)","Placebo capsule containing inert maltodextrin powder. The capsule is identical in size, shape, weight, color (opaque), and texture to the active caffeine capsule to ensure robust blinding. It is administered at the exact same time point (60 minutes pre-exercise) according to the identical body-mass-adjusted dosing scheme (simulating either 3 mg\u002Fkg or 6 mg\u002Fkg).",[22,27],{"type":33,"name":47,"description":48,"armGroupLabels":49,"otherNames":37},"Placebo (Nitrate-Depleted Beetroot Juice)","Nitrate-depleted beetroot juice (Beet It, James White Drinks Ltd., Ipswich, UK) administered as a 70 mL shot. This placebo is identical in taste, smell, appearance, packaging, and viscosity to the active concentrated shot, but has been selectively filtered to contain negligible nitrate levels (\\\u003C0.4 mmol \u002F \\~25 mg of nitrates). It is ingested exactly 3 hours prior to the exercise test.",[16,27],[51],{"name":52,"affiliation":53,"role":54},"Natalia Główka, PhD","Poznan University of Physical Education, Department of Sports Dietetics","PRINCIPAL_INVESTIGATOR",[56],{"name":52,"role":57,"phone":58,"phoneExt":37,"email":59},"CONTACT","+48691756944","glowka@awf.poznan.pl",[61],{"facility":5,"status":37,"city":62,"state":63,"zip":64,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":73},"Poznan","Wielkopolska","61-871","Poland","PL",{"type":68,"coordinates":69},"Point",[70,71],16.92993,52.40692,{"lat":71,"lon":70},[74],{"name":75,"role":57,"phone":76,"phoneExt":37,"email":59},"Natalia Główka","691756944",{"type":78,"investigatorFullName":37,"investigatorTitle":37,"investigatorAffiliation":37,"oldNameTitle":37,"oldOrganization":37},"SPONSOR","100650362","the-effects-of-acute-nitrate-and-caffeine-co-ingestion-on-discipline-specific-exercise-performance-100650362",false,"NCT07748416","The Effects of Acute Nitrate and Caffeine Co-ingestion on Discipline-Specific Exercise Performance.","The Acute Effects of Dietary Nitrate (Beetroot Juice), Caffeine, and Their Combination on Discipline-Specific Exercise Performance, Lactate Kinetics, and Physiological Responses in Trained Functional Fitness Athletes and Elite Junior Swimmers.","Inclusion Criteria:\n\nA) Cohort A (HIFT \u002F CrossFit \u002F Hyrox):\n\n* Aged 18-45 years.\n* Minimum of 2 years of systematic HIFT\u002FCrossFit\u002FHyrox training experience.\n* Performing \\>4 training sessions per week.\n* Ability to perform the HYROX Physical Fitness Test (P'F'T) and has participated in at least one official HYROX event.\n* Possession of a valid medical certificate proving eligibility for competitive sports.\n\nB) Cohort B (Competitive Junior Swimmers):\n\n* Aged 16-19 years.\n* Active member of the Polish Junior National Swimming Team.\n* Minimum of 5 years of competitive swimming experience.\n* Current training volume of at least 8-10 pool training sessions per week.\n* Written informed consent obtained from both the participant and their legal guardian (for minors under 18).\n\nC)Common Criteria for Both Cohorts:\n\n* No history of cardiovascular, respiratory, metabolic, or musculoskeletal disease contradicting high-intensity exercise or stimulant intake.\n* No known food allergies or adverse reactions to beetroot products or caffeine.\n* No current use of medications that alter nitrate\u002Fcaffeine metabolism (e.g., proton pump inhibitors, antibiotics, phosphodiesterase inhibitors).\n* History of uneventful habituation to caffeine use during training\u002Fcompetition.\n* Willingness to abstain from dietary supplements, antibacterial mouthwashes, alcohol, and high-nitrate foods for 48 hours prior to each testing session.\n* Good general health and physical well-being.\n\nExclusion Criteria (Applicable to both cohorts):\n\n* Occurrence of acute musculoskeletal injury or trauma during the study period.\n* Any medical or health contraindications (including severe menstrual disorders, planned pregnancy, or breastfeeding).\n* Failure or refusal to strictly adhere to the dietary, supplementation, and exercise testing protocols.",true,"ALL","16 Years","45 Years",{"count":91,"type":92},112,"ESTIMATED","INTERVENTIONAL",[95],"NA","The purpose of this study is to investigate the acute, separate, and combined ergogenic effects of dietary nitrate (beetroot juice, BJ) and caffeine (CAF) supplementation on discipline-specific athletic performance. The project employs a double-blind, randomized, placebo-controlled, four-arm crossover design. It evaluates two highly distinct, heterogeneous populations of athletes: (A) adult high-intensity functional training (HIFT\u002FCrossFit\u002FHyrox) competitors performing the standardized Hyrox Physical Fitness Test (P'F'T), and (B) elite junior competitive swimmers (National Team members) performing a progressive 8 × 100 m swimming test. The study will assess physical performance, lactate kinetics, subjective exertion, biochemical indices, psychological metrics, and gastrointestinal tolerance.",[98,99,100],"Athletic Performance","Dietary Supplement","Iron Status",[34,102,103,104,105],"Sports nutrition","Swimming","High-Intensity Functional Training","Nitric oxide","NOT_YET_RECRUITING","2026-08-06",{"date":109,"type":110},"2026-08-07","ACTUAL",{"date":112,"type":92},"2026-10-01",{"date":114,"type":92},"2029-06-30",{"name":5,"class":6},1]