[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654496":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":13,"studyPopulation":13,"armGroups":22,"interventions":33,"overallOfficials":39,"centralContacts":43,"locations":49,"responsibleParty":63,"collaborators":13,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":13,"eligibilityCriteria":71,"healthyVolunteers":68,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":13,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":13,"overallStatus":84,"whyStopped":13,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Beijing Tiantan Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Difference in scores of the State-Trait Anxiety Inventory-State (STAI-S)","Difference in scores of the State-Trait Anxiety Inventory-State (STAI-S) from the preoperative baseline (1 day before surgery) to the 5th day after surgery.","Postoperative 5 day",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":13,"primaryPurpose":17,"observationalModel":13,"timePerspective":13,"maskingInfo":18},"RANDOMIZED","PARALLEL","PREVENTION",{"masking":19,"maskingDescription":13,"whoMasked":20},"SINGLE",[21],"OUTCOMES_ASSESSOR",[23,29],{"label":24,"type":25,"description":26,"interventionNames":27},"Dexmedetomidine nasal spray combined with routine perioperative management","ACTIVE_COMPARATOR","Patients in this group will receive dexmedetomidine nasal spray in the ward on the night before surgery and on the morning of surgery.The standard dose is 100μg. For subjects older than 60 years or weighing less than 45 kg, the dose is adjusted to 75 μg. Patients also receive the same routine perioperative management as the control group.",[28],"Drug: Dexmedetomidine",{"label":30,"type":31,"description":32,"interventionNames":13},"Routine perioperative management","NO_INTERVENTION","Patients in this group do not receive any nasal spray intervention. Patients receive routine perioperative management.",[34],{"type":35,"name":36,"description":37,"armGroupLabels":38,"otherNames":13},"DRUG","Dexmedetomidine","Patients will receive dexmedetomidine nasal spray in the ward on the night before surgery (before bedtime) and on the morning of surgery (about 1 - 2 hours before anesthesia induction). When administering the drug, the patient should sit upright with the head slightly forward, shake well before use and pre-pray to activate the device. The standard dose is 100μg (2 sprays in each nostril, 4 sprays in total, 25 μg per spray). For subjects older than 60 years or weighing less than 45 kg, the dose is adjusted to 75 μg (a total of 3 sprays, alternately sprayed into both nostrils, for example, 2 sprays in the left nostril and 1 spray in the right nostril, or vice versa).",[24],[40],{"name":41,"affiliation":5,"role":42},"Yuming Peng, MD,Ph.D","PRINCIPAL_INVESTIGATOR",[44],{"name":45,"role":46,"phone":47,"phoneExt":13,"email":48},"Min Zeng, MD,Ph.D","CONTACT","8610-59976658","fly800727@163.com",[50],{"facility":51,"status":13,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":13},"Beijing Tian Tan Hospital, Capital Medical University","Beijing","Beijing Municipality","100070","China","CN",{"type":58,"coordinates":59},"Point",[60,61],116.39723,39.9075,{"lat":61,"lon":60},{"type":42,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"Yuming Peng","Deputy chief of Department of Anesthesiology","100654496","the-impact-of-dexmedetomidine-nasal-spray-on-perioperative-anxiety-in-neurosurgical-patients-100654496",false,"NCT07801014","The Impact of Dexmedetomidine Nasal Spray on Perioperative Anxiety in Neurosurgical Patients","Inclusion Criteria:\n\n* American Society of Anesthesiologists physical status I to III\n* Scheduled to undergo elective supratentorial tumor resection\n* Preoperative STAI-S score \\>45\n* Obtain written informed consent\n\nExclusion Criteria:\n\n* Severe hepatic or renal insufficiency\n* Allergy to dexmedetomidine or its excipients\n* Severe bradycardia (heart rate \\\u003C50 bpm), sick sinus syndrome, or second-\u002Fthird-degree AV block without pacemaker\n* Use of α2-agonists, benzodiazepines, or other sedatives\u002Fanalgesics within 24 hours preoperatively\n* History of alcohol, drug, or psychoactive substance dependence\n* Diagnosed or suspected obstructive sleep apnea syndrome\n* Nasal anatomical abnormalities, acute rhinitis, epistaxis, or other nasal conditions affecting drug administration\n* Pregnancy or lactation\n* Communication barriers, psychiatric disorders, or cognitive impairment precluding scale completion\n* Visual\u002Fhearing impairment or inability to read","ALL","18 Years","75 Years",{"count":76,"type":77},114,"ESTIMATED","INTERVENTIONAL",[80],"NA","This randomized clinical trial aims to evaluate the effect of preoperative use of dexmedetomidine nasal spray on improving perioperative anxiety levels in patients undergoing elective supratentorial tumor resection.",[83,36],"Anxiety","NOT_YET_RECRUITING","2026-08-30",{"date":87,"type":88},"2026-09-02","ACTUAL",{"date":90,"type":77},"2026-09-15",{"date":92,"type":77},"2028-05-31",{"name":5,"class":6},1]