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The study will combine imaging data with patient demographics and clinical information (including prospective outcomes) to aid the development and\u002For validation of new or existing image analysis algorithms and software tools to improve diagnosis, clinical risk discrimination and prediction. Specifically, ORFAN will evaluate the specificity, utility and predictive value of newly developed image analysis methods. ORFAN will recruit and follow-up patients prospectively, linking the index CT scan with blood biomarkers, genetic information as well as information on disease progression (recorded through follow-up CT scans) and clinical outcomes data.\n\nThe study will also collect CT scans performed in the past and link them with clinical factors and prospective outcomes data collected after the index scan was performed.","Patients will be recruited from secondary and tertiary NHS care providers in the UK and from international sites.",[44,47,50,53],{"label":45,"type":38,"description":46,"interventionNames":38},"Group 1","Participants attending cardiology department, hypertension or outpatient clinics.",{"label":48,"type":38,"description":49,"interventionNames":38},"Group 2","Participants who are recruited prospectively, during their clinically indicated CT scan, and they are followed-up prospectively for clinical endpoints; A follow-up CCTA at least 6 months later will be offered to a subgroup of these patients, to assess disease progression.",{"label":51,"type":38,"description":52,"interventionNames":38},"Group 3","Individuals where at least 6 months have elapsed from previous CCTA will undergo repeat CCTA scan and enter prospective follow up for clinical endpoints.",{"label":54,"type":38,"description":55,"interventionNames":38},"Group 4","Cohort of consecutive patients who have undergone clinical CTAs or unenhanced CT chest, abdomen and pelvis in the past, linking the index CT scan with prospective outcomes collection already accumulated.",[57],{"name":58,"affiliation":5,"role":59},"Charalambos Antoniades, Prof","PRINCIPAL_INVESTIGATOR",[61,65],{"name":62,"role":63,"phone":38,"phoneExt":38,"email":64},"Kenneth Chan, Dr","CONTACT","kenneth.chan@cardiov.ox.ac.uk",{"name":66,"role":63,"phone":38,"phoneExt":38,"email":67},"Ahmad Abdullrahman, 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City","Kansas",{"type":77,"coordinates":130},[131,132],-94.62746,39.11417,{"lat":132,"lon":131},[135],{"name":136,"role":63,"phone":38,"phoneExt":38,"email":137},"Bloom, Dr","Stephen.Bloom@HCAHealthcare.com",{"facility":139,"status":71,"city":127,"state":128,"zip":38,"country":74,"countryCode":75,"cosmosGeoPoint":140,"geoPoint":142,"contacts":143},"St Luke's Hospital",{"type":77,"coordinates":141},[131,132],{"lat":132,"lon":131},[144],{"name":145,"role":63,"phone":38,"phoneExt":38,"email":146},"Centerp, Dr","Ehutt@saint-lukes.org",{"facility":148,"status":71,"city":149,"state":150,"zip":38,"country":74,"countryCode":75,"cosmosGeoPoint":151,"geoPoint":155,"contacts":156},"NIH National Heart, Lunch, and Blood Institute","Bethesda","Maryland",{"type":77,"coordinates":152},[153,154],-77.10026,38.98067,{"lat":154,"lon":153},[157],{"name":158,"role":63,"phone":38,"phoneExt":38,"email":159},"Mehta, Dr","nehal.mehta@nih.gov",{"facility":161,"status":71,"city":162,"state":163,"zip":38,"country":74,"countryCode":75,"cosmosGeoPoint":164,"geoPoint":168,"contacts":169},"Brigham and Women's Hospital","Boston","Massachusetts",{"type":77,"coordinates":165},[166,167],-71.05977,42.35843,{"lat":167,"lon":166},[170],{"name":171,"role":63,"phone":38,"phoneExt":38,"email":172},"Blankstein, Prof","rblankstein@bwh.harvard.edu",{"facility":174,"status":71,"city":175,"state":176,"zip":38,"country":74,"countryCode":75,"cosmosGeoPoint":177,"geoPoint":181,"contacts":182},"Cleveland Clinic","Cleveland","Ohio",{"type":77,"coordinates":178},[179,180],-81.69541,41.4995,{"lat":180,"lon":179},[183],{"name":184,"role":63,"phone":38,"phoneExt":38,"email":185},"Desai, Prof","desaim2@ccf.org",{"facility":187,"status":71,"city":188,"state":189,"zip":38,"country":74,"countryCode":75,"cosmosGeoPoint":190,"geoPoint":194,"contacts":195},"UT Southwestern Medical 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University","Budapest","Hungary","HU",{"type":77,"coordinates":352},[353,354],19.04045,47.49835,{"lat":354,"lon":353},[357],{"name":358,"role":63,"phone":38,"phoneExt":38,"email":359},"Maurovich-Horvat, Prof","maurovich-horvat.pal@med.semmelweis-univ.hu",{"facility":361,"status":71,"city":362,"state":38,"zip":38,"country":363,"countryCode":364,"cosmosGeoPoint":365,"geoPoint":369,"contacts":370},"Centro Cardiologico Monzino IRCCS, University of Milan","Milan","Italy","IT",{"type":77,"coordinates":366},[367,368],9.18951,45.46427,{"lat":368,"lon":367},[371],{"name":372,"role":63,"phone":38,"phoneExt":38,"email":373},"Pontone, Prof","gianluca.pontone@cardiologicomonzino.it",{"facility":375,"status":71,"city":376,"state":38,"zip":38,"country":363,"countryCode":364,"cosmosGeoPoint":377,"geoPoint":381,"contacts":382},"Isola Tiberina-Gemelli Isola 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collecting CT scans, biological material and outcomes data, to develop and validate novel biomarkers of cardiometabolic and other disease risk.",[596,597],"Cardiovascular Diseases","Cardiovascular Risk Factors","2026-07-30",{"date":600,"type":601},"2026-07-31","ACTUAL",{"date":603,"type":601},"2016-02-23",{"date":605,"type":591},"2030-02",{"name":5,"class":6},45]