[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600345":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":17,"studyPopulation":18,"armGroups":19,"interventions":25,"overallOfficials":31,"centralContacts":36,"locations":46,"responsibleParty":81,"collaborators":13,"id":83,"slug":84,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":85,"sex":91,"minAge":92,"maxAge":13,"enrollmentInfo":93,"targetDuration":13,"studyType":96,"phases":13,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":48,"whyStopped":13,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"Avicenna Military Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Prognostic value of PvCO2-PaCO2\u002FCa O2-CvO2 in patients with septic shock","The ability of PvCO2-PaCO2\u002FCa O2-CvO2 to predict mortality in patients with septic shock. These biological values will be measure using arterial and central venous blood gaz.","From patient inclusion (baseilie = H0) then at H2, H6, H 12 and H24 (H = hours)",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"COHORT","PROSPECTIVE","The ratio of the venous-arterial carbon dioxide partial pressure difference to the arteriovenous oxygen content difference (Pv-aCO₂\u002FCa-vO₂) may be a marker of anaerobic metabolism in patients with acute circulatory failure. This study aims to compare the kinetics of the PvCO2-PaCO2\u002FCaO2-CvO2 ratio with a classic marker of anaerobic metabolism (arterial lactate) in the early phase of septic shock.","Patients aged over 18 years presenting with septic shock, defined as sepsis with persistent hypotension requiring vasopressors to maintain a mean arterial pressure (MAP) ≥ 65 mmHg and lactatemia \\> 2 mmol\u002FL despite adequate fluid resuscitation. Sepsis is defined by the presence of a suspected or confirmed infectious source associated with organ dysfunction (neurological, respiratory, renal, hepatic, or hematological). \\[Sepsis 3 criteria\\]",[20],{"label":21,"type":13,"description":22,"interventionNames":23},"Adult patients with septic shock.","Patients aged over 18 years presenting with septic shock. defined as sepsis with persistent hypotension requiring vasopressors to maintain a mean arterial pressure (MAP) ≥ 65 mmHg and lactatemia \\> 2 mmol\u002FL despite adequate fluid resuscitation.",[24],"Diagnostic Test: PvCO2-PaCO2\u002FCaO2-CvO2 ratio",[26],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":13},"DIAGNOSTIC_TEST","PvCO2-PaCO2\u002FCaO2-CvO2 ratio","Patients diagnosed with septic shock will undergo serial measurements of arterial and venous blood gas analyses, arterial lactate levels, and calculation of the Pv-aCO₂\u002FCa-vO₂ ratio at predefined time points: H0 (baseline), H2, H6, H12, and H24.\n\nCalculation Formulas:\n\n1. Arterial Oxygen Content (CaO₂):CaO2 = SaO2 × Hb × 1,34 + PaO2 × 0,0031\n2. Venous Oxygen Content (CvO₂):CvO2 = SvO2 × Hb × 1,34 + PvO2 × 0,0031\n3. Pv-aCO₂\u002FCa-vO₂ Ratio: P(v-a) CO2\u002FC(a-v)O2=(PcvCO2-PaCO2)\u002F(CaO2 -CcvO2).",[21],[32],{"name":33,"affiliation":34,"role":35},"Younes Aissaoui Pr","Cadi Ayyad University. Faculty of Medicine and Pharmacy. Avicenna Military Hospital.","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":13,"email":41},"Younes Aissaoui Professor of critical care medicine","CONTACT","+212661403332","younes.aissaoui@uca.ma",{"name":43,"role":39,"phone":44,"phoneExt":13,"email":45},"Ayoub Belhadj Professor of critical care medicine","+212670279562","ayoubbelhadj@gmail.com",[47,66,74],{"facility":5,"status":48,"city":49,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"RECRUITING","Marrakesh","40000","Morocco","MA",{"type":54,"coordinates":55},"Point",[56,57],-7.99994,31.63416,{"lat":57,"lon":56},[60,63,65],{"name":61,"role":39,"phone":40,"phoneExt":13,"email":62},"Younes Aissaoui, MD","younes.aissaoui@live.fr",{"name":64,"role":39,"phone":13,"phoneExt":13,"email":62},"Younes Aissaoui",{"name":61,"role":35,"phone":13,"phoneExt":13,"email":13},{"facility":5,"status":48,"city":49,"state":13,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":67,"geoPoint":69,"contacts":70},{"type":54,"coordinates":68},[56,57],{"lat":57,"lon":56},[71,73],{"name":13,"role":39,"phone":72,"phoneExt":13,"email":62},"0661403332",{"name":64,"role":39,"phone":13,"phoneExt":13,"email":13},{"facility":75,"status":48,"city":49,"state":13,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":76,"geoPoint":78,"contacts":79},"Department of critical care Medicine. Avicenna Military Hospital",{"type":54,"coordinates":77},[56,57],{"lat":57,"lon":56},[80],{"name":64,"role":39,"phone":72,"phoneExt":13,"email":41},{"type":35,"investigatorFullName":61,"investigatorTitle":82,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"Professor","100600345","the-pvco2-paco2cao2-cvo2-ratio-in-septic-shock-100600345",false,"NCT07096284","The PvCO2-PaCO2\u002FCaO2-CvO2 Ratio in Septic Shock","Prognostic Value and Kinetics of the PvCO2-PaCO2\u002FCaO2-CvO2 Ratio Compared to Arterial Lactate in the Initial Phase of Septic Shock","SepsisO2CO2R","Inclusion Criteria:\n\nPatients aged over 18 years presenting with septic shock, defined as sepsis with persistent hypotension requiring vasopressors to maintain a mean arterial pressure (MAP) ≥ 65 mmHg and lactatemia \\> 2 mmol\u002FL despite adequate fluid resuscitation. Sepsis is defined by the presence of a suspected or confirmed infectious source associated with organ dysfunction (neurological, respiratory, renal, hepatic, or hematological). \\[Sepsis 3 criteria\\]\n\nExclusion Criteria:\n\n* Absence of central venous access.\n* Central venous access not positioned in the superior vena cava (e.g., femoral access).","ALL","18 Years",{"count":94,"type":95},30,"ESTIMATED","OBSERVATIONAL","The ratio of the venous-arterial carbon dioxide partial pressure difference to the arteriovenous oxygen content difference (Pv-aCO₂\u002FCa-vO₂) may be a marker of anaerobic metabolism in patients with acute circulatory failure. This study aims to assess the prognostic value of the PvCO2-PaCO2\u002FCaO2-CvO2 in the early phase of septic shock.",[99],"Septic Shock",[101,102],"sepsis","anaerobic metabolism","2026-03-28",{"date":105,"type":106},"2026-03-31","ACTUAL",{"date":108,"type":106},"2025-01-05",{"date":110,"type":95},"2026-06-30",{"name":5,"class":6},3]