[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100655987":3},{"organization":4,"outcomesModule":7,"designInfo":20,"detailedDescription":23,"studyPopulation":24,"armGroups":25,"interventions":31,"overallOfficials":11,"centralContacts":37,"locations":43,"responsibleParty":57,"collaborators":11,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":11,"enrollmentInfo":70,"targetDuration":11,"studyType":73,"phases":11,"briefSummary":74,"conditions":75,"keywords":79,"overallStatus":46,"whyStopped":11,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Queen Mary Hospital, Hong Kong","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"Correlation between novel (single-beat) and conventional (two-beat) TE-e' values",null,"At the time of index TTE (single time point for each patient) during the course of ICU stay (from day 1 of ICU admission till ICU discharge, up to 1 month)",[14,16,18],{"measure":15,"description":11,"timeFrame":12},"Correlation between novel and conventional methods in obtaining septal e' and s' velocities - At time of index TTE",{"measure":17,"description":11,"timeFrame":12},"Correlation between clinical evaluation of LAP and TE-e' value",{"measure":19,"description":11,"timeFrame":12},"Correlation between other echocardiographic parameters of LAP (E\u002FA ratio, LAVi, TR Vmax, lung ultrasound 6-point protocol) and TE-e' value",{"allocation":11,"interventionModel":11,"interventionModelDescription":11,"primaryPurpose":11,"observationalModel":21,"timePerspective":22,"maskingInfo":11},"COHORT","PROSPECTIVE","Left atrial pressure (LAP) is an important measure in the care of critically ill patients but usually requires an invasive catheter to assess directly. Echocardiography offers a non-invasive alternative. One promising marker, TE-e' (the time difference between the onset of the mitral inflow E wave and the septal e' wave on tissue Doppler imaging), was recently incorporated into the 2025 American Society of Echocardiography (ASE) diastolic function guidelines. The conventional method for calculating TE-e' requires measurements from two separate heartbeats, introducing potential error from beat-to-beat heart rate variability - a common issue in the critically ill patients. This study assesses a novel single-beat method, in which both waveforms are captured on the same Doppler display within one cardiac cycle, eliminating that source of variability. Patients undergoing clinically indicated transthoracic echocardiography (TTE) in the Adult Intensive Care Unit of Queen Mary Hospital, Hong Kong will have TE-e' measured by both methods, along with other echocardiographic parameters associated with LAP, to evaluate correlation between the two methods and their relationship with clinically assessed LAP.","Patients admitted to Adult Intensive Care Unit requiring a TTE",[26],{"label":27,"type":11,"description":28,"interventionNames":29},"Single cohort","each patient serves as their own comparison - conventional vs. novel method measured within the same transthoracic echocardiography study",[30],"Diagnostic Test: Echocardiography",[32],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":11},"DIAGNOSTIC_TEST","Echocardiography","Full echocardiogram performed on recruited patients.",[27],[38],{"name":39,"role":40,"phone":41,"phoneExt":11,"email":42},"Wincy Ng, MBBS","CONTACT","22551331","wincyngwingsze@gmail.com",[44],{"facility":45,"status":46,"city":47,"state":11,"zip":11,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Adult Intensive Care Unit, Queen Mary Hospital","RECRUITING","Hong Kong","HK",{"type":50,"coordinates":51},"Point",[52,53],114.17469,22.27832,{"lat":53,"lon":52},[56],{"name":39,"role":40,"phone":41,"phoneExt":11,"email":42},{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Wincy Wing-Sze Ng","Associate Consultant","100655987","the-use-of-single-beat-te-e-in-evaluation-of-left-atrial-pressure-in-critically-ill-patients-the-telap-icu-trial-100655987",false,"NCT07820319","The Use of Single-Beat TE-e' in Evaluation of Left Atrial Pressure in Critically Ill Patients: The TELAP-ICU Trial","TELAP-ICU","Inclusion Criteria:\n\n* Adult patients ≥18 years admitted to the QMH Adult Intensive Care Unit (AICU)\n* Requiring a transthoracic echocardiogram (TTE) as part of routine clinical care\n* TE-e' obtainable by both the conventional and the novel method\n\nExclusion Criteria:\n\n* Patients \\\u003C18 years of age\n* Patients in atrial fibrillation\n* Patients with a poor TTE acoustic window\n* Patients in whom TE-e' is technically difficult to obtain or interpret by either method","ALL","18 Years",{"count":71,"type":72},50,"ESTIMATED","OBSERVATIONAL","This study evaluates a new single-beat echocardiographic technique (TE-e', the time difference between the onset of the mitral inflow E wave and the septal e' wave on tissue Doppler imaging) for estimating left atrial pressure (LAP) in critically ill patients, comparing it against the standard two-beat method. The goal is to determine whether the faster, single-beat method gives results as reliable as the conventional method, and whether it can help identify patients with elevated left atrial pressure without an invasive procedure.",[76,77,78,34],"Critical Illness","Elevated Left Atrial Pressure","Left Ventricular Diastolic Dysfunction",[80,81,82,83,84,85,86,87,88],"critical care echocardiography","transthoracic echocardiography","left atrial pressure","diastolic dysfunction","critically ill","echocardiography","tissue doppler imaging","intensive care","TE-e'","2026-09-09",{"date":91,"type":92},"2026-09-15","ACTUAL",{"date":94,"type":92},"2026-07-01",{"date":96,"type":72},"2027-06-30",{"name":5,"class":6},1]