[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650892":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":25,"locations":25,"responsibleParty":29,"collaborators":25,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":37,"acronym":25,"eligibilityCriteria":38,"healthyVolunteers":35,"sex":39,"minAge":40,"maxAge":41,"enrollmentInfo":42,"targetDuration":25,"studyType":45,"phases":46,"briefSummary":48,"conditions":49,"keywords":25,"overallStatus":51,"whyStopped":25,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":25},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Group: letrozole followed by misoprostol","EXPERIMENTAL","Group A will receive letrozole followed by misoprostol.",[13],"Procedure: Intervention Group: letrozole followed by misoprostol",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group: misoprostol only","ACTIVE_COMPARATOR","Group B will receive misoprostol only, without prior letrozole pretreatment.",[19],"Procedure: Control Group: misoprostol only",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Group A (Intervention Group) will receive letrozole followed by misoprostol.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Group B (Control Group) will receive misoprostol only, without prior letrozole pretreatment",[15],{"type":30,"investigatorFullName":31,"investigatorTitle":32,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Eman Ali Abdullah Ali","Doctor","100650892","the-value-of-pretreatment-with-letrozole-on-induction-time-of-medical-evacuation-with-misoprostol-in-cases-of-missed-abortion-100650892",false,"NCT07753655","The Value of Pretreatment With Letrozole on Induction Time of Medical Evacuation With Misoprostol in Cases of Missed Abortion","Inclusion Criteria:\n\n* Women aged 18 - 45 years.\n* Diagnosed with missed abortion confirmed by ultrasound (absent fetal heartbeat and\u002For no embryonic development).\n* Gestational age ≤ 12 weeks based on last menstrual period\n* Hemoglobin levels \\>10 g\u002FdL.\n* BMI ranging from 25 to 35 kg\u002Fm2.\n* Hemodynamically stable and no signs of infection.\n\nExclusion Criteria:\n\n* Incomplete abortion, inevitable abortion, or threatened miscarriage.\n* Suspected ectopic pregnancy and molar pregnancy.\n* History of allergy or contraindication to misoprostol or letrozole.\n* Coagulopathy or use of anticoagulant medications.\n* Chronic medical diseases (e.g., uncontrolled diabetes, cardiovascular disease, liver or renal dysfunction).\n* Prior uterine surgery that contraindicates medical abortion (e.g., classical cesarean section, myomectomy with uterine entry).\n* Uterine anomalies.\n* Women unsure of LMP","FEMALE","18 Years","45 Years",{"count":43,"type":44},74,"ESTIMATED","INTERVENTIONAL",[47],"NA","The aim is to evaluate the effect of letrozole pretreatment on the induction time during medical evacuation using misoprostol in women diagnosed with missed abortion, and to compare its efficacy and safety to misoprostol alone.",[50],"Letrozole","NOT_YET_RECRUITING","2026-08-04",{"date":54,"type":55},"2026-08-07","ACTUAL",{"date":57,"type":44},"2026-08-15",{"date":59,"type":44},"2027-03-01",{"name":5,"class":6}]