[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100323886":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":45,"centralContacts":50,"locations":60,"responsibleParty":80,"collaborators":34,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":89,"sex":90,"minAge":91,"maxAge":34,"enrollmentInfo":92,"targetDuration":34,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":101,"overallStatus":63,"whyStopped":34,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"Milton S. Hershey Medical Center","OTHER",[8,14,20,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Tilt + external pressure","EXPERIMENTAL","Tilt + external pressure on legs performed in both \"BP elevated with standing\" and \"BP maintained with standing\" groups.",[13],"Other: Tilt + external pressure",{"label":15,"type":16,"description":17,"interventionNames":18},"Tilt + no external pressure","PLACEBO_COMPARATOR","Tilt + no external pressure performed in both \"BP elevated with standing\" and \"BP maintained with standing\" groups.",[19],"Other: Tilt + no external pressure.",{"label":21,"type":10,"description":22,"interventionNames":23},"Limb occlusion + negative pressure","Limb occlusion + negative pressure performed in both \"BP elevated with standing\" and \"BP maintained with standing\" groups.",[24],"Other: Limb occlusion + negative pressure",{"label":26,"type":16,"description":27,"interventionNames":28},"Limb occlusion + no negative pressure","Limb occlusion + no negative pressure performed in both \"BP elevated with standing\" and \"BP maintained with standing\" groups.",[29],"Other: Limb occlusion + no negative pressure",[31,35,39,42],{"type":6,"name":9,"description":32,"armGroupLabels":33,"otherNames":34},"In Visit 1, the anti-shock trousers will be inflated to 20, 40, or 60 mmHg. BP will be measured 3 times from the brachial artery. Then the table will be tilted head up to a maximum of 70o for up to 10 min, while BP will be measured from the brachial artery at 1 min intervals. The tilt table is returned to 0o and the resting supine baseline BP will be collected. Then, the anti-shock trousers will be inflated to a different pressure (20, 40, or 60 mmHg) and the head up tilt will be repeated. Repetitions at the various pressures will be performed in a random order with suitable resting intervals in between the tilting bouts.",[9],null,{"type":6,"name":36,"description":37,"armGroupLabels":38,"otherNames":34},"Tilt + no external pressure.","In Visit 1, the anti-shock trousers will NOT be inflated. Auscultatory BP will be measured 3 times from the brachial artery. Thereafter, the table will be tilted head up to a maximum of 70o for up to 10 min, while BP will be measured from the brachial artery at 1 min intervals.",[15],{"type":6,"name":21,"description":40,"armGroupLabels":41,"otherNames":34},"In Visit 2, a cuff will be placed on the thigh of a leg that is sealed in an airtight pressure tank. After the cuff is inflated to 250 mmHg, the pressure in the tank will be reduced to -100mmHg for 2 minutes. The application of negative pressure creates a suction effect on the leg, and leads to an overall increase in pressure gradient across the blood vessel wall and induces vascular distension.",[21],{"type":6,"name":26,"description":43,"armGroupLabels":44,"otherNames":34},"In Visit 2, a cuff will be placed on the thigh of a leg that is sealed in an airtight pressure tank. The cuff is inflated to 250 mmHg for 2 minutes, but the pressure in the tank is not changed.",[26],[46],{"name":47,"affiliation":48,"role":49},"Jian Cui","Penn State College of Medicine","PRINCIPAL_INVESTIGATOR",[51,56],{"name":52,"role":53,"phone":54,"phoneExt":34,"email":55},"Jian Cui, PhD","CONTACT","717-531-1799","jcui@pennstatehealth.psu.edu",{"name":57,"role":53,"phone":58,"phoneExt":34,"email":59},"Kris Gray","717-531-4589","kgray1@pennstatehealth.psu.edu",[61],{"facility":62,"status":63,"city":64,"state":65,"zip":66,"country":67,"countryCode":68,"cosmosGeoPoint":69,"geoPoint":74,"contacts":75},"Penn State Milton S. Hershey Medical Center","RECRUITING","Hershey","Pennsylvania","17033","United States","US",{"type":70,"coordinates":71},"Point",[72,73],-76.65025,40.28592,{"lat":73,"lon":72},[76,79],{"name":77,"role":53,"phone":78,"phoneExt":34,"email":59},"Kristen Gray","7175314589",{"name":47,"role":53,"phone":54,"phoneExt":34,"email":55},{"type":49,"investigatorFullName":47,"investigatorTitle":81,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"Associate Professor of Medicine","100323886","the-venous-distension-reflex-and-orthostatic-hypertension-100323886",false,"NCT03496792","The Venous Distension Reflex and Orthostatic Hypertension","OH","Inclusion Criteria:\n\n* Are capable of giving informed consent\n* Are of any race or ethnicity\n* Are fluent in written and spoken English\n* Whose history and physical exam did not uncover any exclusion criteria\n* Are 18 years of age\n\nFor subjects with elevated standing BP\n\n* Systolic BP (SBP) during standing is at least 10 mmHg \\> the supine SBP\n* Patients with a diagnosis of stage I hypertension without other chronic diseases may be INCLUDED\n\nFor normal subjects without elevated standing BP\n\n* The change in SBP by standing is within ± 5 mmHg from the supine SBP\n* Matched gender, similar age and BMI (within 10%) to participants with elevated standing BP\n* Free of acute or chronic medical conditions\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years of age\n* Are a pregnant or nursing woman\n* Are a prisoner or institutionalized individual or unable to consent\n* Have chronic diseases (e.g. heart, lung, neuromuscular disease, or cancer) other than stage I hypertension\n* Have orthostatic hypotension or a history of syncope\n* Current smoker\n* History of blood clots",true,"ALL","18 Years",{"count":93,"type":94},30,"ESTIMATED","INTERVENTIONAL",[97],"NA","This research is being done to find out whether distension of veins in legs will cause a rise in blood pressure (orthostatic hypertension).",[100],"Blood Pressure",[102],"venous distension reflex","2026-07-08",{"date":105,"type":106},"2026-07-09","ACTUAL",{"date":108,"type":106},"2020-03-10",{"date":110,"type":94},"2027-11-01",{"name":5,"class":6},1]