[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100482044":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":54,"collaborators":18,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":18,"eligibilityCriteria":62,"healthyVolunteers":59,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":18,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":77,"overallStatus":38,"whyStopped":18,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment","EXPERIMENTAL","Patients that proceed with permanent implantation of a spinal cord stimulator.",[13],"Device: Permanent Epidural Spinal Cord Stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","NO_INTERVENTION","Patients who do not proceed with permanent implantation of a spinal cord stimulator.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DEVICE","Permanent Epidural Spinal Cord Stimulation","Permanent Spinal Cord Stimulation implanted in participants undergoing routine care for management of chronic neuropathic pain.",[9],[26],{"name":27,"affiliation":28,"role":29},"Marshall Holland, MD","The University of Alabama at Birmingham","PRINCIPAL_INVESTIGATOR",[31],{"name":32,"role":33,"phone":34,"phoneExt":18,"email":35},"Chris Gonzalez, MS","CONTACT","(205) 975-3732","clgonzalez@uabmc.edu",[37],{"facility":5,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","Birmingham","Alabama","35233","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-86.80249,33.52066,{"lat":48,"lon":47},[51],{"name":27,"role":33,"phone":52,"phoneExt":18,"email":53},"2059342654","mtholland@uabmc.edu",{"type":29,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Marshall Holland","Assistant Professor","100482044","therapeutic-mechanisms-of-epidural-spinal-cord-stimulation-100482044",false,"NCT05556902","Therapeutic Mechanisms of Epidural Spinal Cord Stimulation","Inclusion Criteria:\n\n1. Male or Female, age 18-89\n2. Chronic pain for more than 3 months\n3. Willing to visit a research lab\n4. Willing to undergo a blood draw\n5. Able to provide written informed consent\n\nExclusion Criteria\n\n1. History of neurological disease (e.g., dementias, Parkinson's)\n2. History of stroke\n3. Current diagnosis of cancer\n4. Subject is unwilling or unable to comply with the protocol","ALL","18 Years","89 Years",{"count":67,"type":68},80,"ESTIMATED","INTERVENTIONAL",[71],"NA","The purpose of this study in patients undergoing routine care epidural spinal cord stimulation (SCS) is to determine 1) whether SCS reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension, 2) whether higher baseline BP (i.e., hypertension) predicts reductions in pain following SCS, and finally 3) whether different SCS waveforms elicits stimulus-evoked compound action potentials (ECAPs) in spinal cord and at the cortex (electroencephalography, and magnetoenchphalography).",[74,75,76],"Blood Pressure","Low Back Pain","Hypertension",[78,79,80,81],"Spinal Cord Stimulation","Epidural Spinal Cord Stimulation","SCS","Arterial Blood Pressure","2026-08-06",{"date":84,"type":85},"2026-08-11","ACTUAL",{"date":87,"type":85},"2022-08-02",{"date":89,"type":68},"2030-05-01",{"name":5,"class":6},1]