[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100555708":3},{"organization":4,"outcomesModule":7,"designInfo":33,"detailedDescription":42,"studyPopulation":32,"armGroups":43,"interventions":55,"overallOfficials":32,"centralContacts":32,"locations":32,"responsibleParty":61,"collaborators":32,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":32,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":32,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":91,"whyStopped":32,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":32},{"fullName":5,"class":6},"South Valley University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":26,"otherOutcomes":32},[9,13,15,17,20,22,24],{"measure":10,"description":11,"timeFrame":12},"Vital signs","Heart Rate (HR) b\u002Fmin","one week",{"measure":14,"description":14,"timeFrame":12},"Respiratory rate RR\u002Fmin",{"measure":16,"description":16,"timeFrame":12},"Blood Pressure mmHg",{"measure":18,"description":19,"timeFrame":12},"Arterial blood gases (ABG):-","PH",{"measure":21,"description":21,"timeFrame":12},"PCO2 mmHg",{"measure":23,"description":23,"timeFrame":12},"HCO3 mEQ\u002FLiter",{"measure":25,"description":25,"timeFrame":12},"PSAO2 mmHg",[27,30],{"measure":28,"description":29,"timeFrame":12},"Ventilator parameters","Minute Ventilation L\u002Fmin",{"measure":31,"description":31,"timeFrame":12},"Tidal Volume L\u002Fbreath",null,{"allocation":34,"interventionModel":35,"interventionModelDescription":36,"primaryPurpose":37,"observationalModel":32,"timePerspective":32,"maskingInfo":38},"RANDOMIZED","PARALLEL","Our Study was performed on sixty patients with VIDD from both genders. All patients will be referred by a physician. All patients were randomly assigned into two groups equal in number","TREATMENT",{"masking":39,"maskingDescription":36,"whoMasked":40},"SINGLE",[41],"PARTICIPANT","The study is a prospective experimental study on adult patients admitted to the Critical Care Department in Qasr Al-Ainy. This study is conducted prospectively to assess the efficiency of trigger sensitivity adjustment on patients with ventilator-induced diaphragmatic dysfunction (VIDD).1. Flow Trigger: This type of trigger responds to the gas flow during inspiration. A flow trigger measures the rate of change of flow as the patient begins to inhale. When the flow reaches a certain threshold, the ventilator is triggered to deliver a breath.\n\n1. Laboratory investigations: Arterial blood gases (ABG):- (PH, PCO2, HCO3, and PO2) after the session.\n2. Ventilator Parameters:( a) Minute Ventilation, b) Tidal Volume, c) Rapid Shallow breathing index, d) Negative Inspiratory Force (NIF) will be measured pre and post-treatment",[44,50],{"label":45,"type":46,"description":47,"interventionNames":48},"Study group","EXPERIMENTAL","Group (A) (study group) will include 30 patients who practiced flow trigger sensitivity adjustment on mechanical ventilation for 1 week twice daily in addition to their plan of treatment.",[49],"Device: Practice flow trigger sensitivity adjustment on mechanical ventilation for 1 week twice daily in addition to their plan of treatment.",{"label":51,"type":52,"description":53,"interventionNames":54},"Controlled group","ACTIVE_COMPARATOR","Group (B) (controlled group) will include 30 patients who received their routine plan of weaning of mechanical ventilator (controlled mode then spontaneous mode and finally spontaneous breathing trial).",[49],[56],{"type":57,"name":58,"description":59,"armGroupLabels":60,"otherNames":32},"DEVICE","Practice flow trigger sensitivity adjustment on mechanical ventilation for 1 week twice daily in addition to their plan of treatment.","All patients were investigated by routine investigation (vital signs, arterial blood gas, ventilator mode, and the parameters).\n\nTwo sessions were implemented per day for the study group for one week. The Trigger sensitivity adjustment trial begins with applying a load of 30% of the first recorded Negative Inspiratory Force (NIF).\n\n1. st Day 1st session, 30% 5 min.\n2. nd session, 30% 10 min.\n\n2nd Day 1st session, 30% 15 min 2nd session, 30% 20 min.\n\n3rd Day 1st session, 30% 25 min. 2nd session, 30% 30 min.\n\n4th Day 1st session, 40% 5 min. 2nd session, 40% 10 min.\n\n5th Day 1st session 40% 15 min 2nd session 40% 20 min.\n\n6th Day 1st session 40% 25 min. 2nd session 40% 30 min.\n\n7th Day 1st session 50% 5 min. 2nd session 50% 10 min.",[51,45],{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","Ibrahim Abuzaid","Director, Head of Department of Physiotherapy for Cardiovascular\u002FRespiratory and Geriatrics","100555708","therapeutically-alternatives-in-ventilator-induced-diaphragm-dysfunction-critically-ill-patients-100555708",false,"NCT06515600","Therapeutically Alternatives In Ventilator-Induced Diaphragm Dysfunction Critically Ill Patients","Does Flow Trigger Sensitivity Adjustment Is Translational Mechanisms For Therapeutically Alternatives In Ventilator-Induced Diaphragm Dysfunction Critically Ill Patients?","Age (years)\n\nWeight (kg)\n\nHeight (cm)\n\nBMI (kg\u002Fm²)\n\nInclusion Criteria:\n\n* Patients who had undergone MV for 48 hours or more in a controlled mode.\n* Patients could not generate maximum inspiratory pressure of more than 15 mbar\n* Patients had diaphragmatic excursion less than 3 cm. (normal level from 3 to 5 cm.)(It can increase in a condition person to 7-8 cm).\n* Patients had a diaphragmatic thickness fraction of less than 30%\n\nExclusion Criteria:\n\n* Patients with comorbidities interfering and compromising weaning like cardiac arrhythmia, pericardial effusion, congestive heart failure, or unstable acute coronary syndrome.\n* Patients who had inadequate training performance of the inspiratory muscle such as those having myopathy or neuropathy.\n* Patients hemodynamically unstable.\n* Patients who had a major neurological deficit.\n* Sedated Patients.",true,"ALL","20 Years","90 Years",{"count":77,"type":78},30,"ESTIMATED","INTERVENTIONAL",[81],"NA","The study is a prospective experimental study on adult patients admitted to the Critical Care Department in Qasr Al-Ainy. This study is conducted prospectively to assess the efficiency of trigger sensitivity adjustment on patients with ventilator-induced diaphragmatic dysfunction (VIDD).",[84],"Ventilator-Induced Diaphragmatic Dysfunction",[86,87,88,89,90],"Trigger Sensitivity","Diaphragmatic dysfunction","Mechanical Ventilator","Minute Ventilation","Tidal Volume","NOT_YET_RECRUITING","2024-07-18",{"date":94,"type":95},"2024-07-23","ACTUAL",{"date":97,"type":78},"2024-08-01",{"date":99,"type":78},"2024-10-15",{"name":5,"class":6}]