[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646542":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":38,"centralContacts":42,"locations":53,"responsibleParty":71,"collaborators":31,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":31,"eligibilityCriteria":80,"healthyVolunteers":77,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":31,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":56,"whyStopped":31,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"University Health Network, Toronto","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"LIFUS - GPi","EXPERIMENTAL","Bilateral thetaburst LIFUS stimulation to globus pallidus",[13],"Device: LIFUS - GPi Active",{"label":15,"type":10,"description":16,"interventionNames":17},"LIFUS - DN","Bilateral thetaburst LIFUS stimulation to dentate nucleus",[18],"Device: LIFUS - DN Active",{"label":20,"type":21,"description":22,"interventionNames":23},"LIFUS - Sham","SHAM_COMPARATOR","Bilateral Sham LIFUS stimulation",[24],"Device: LIFUS - Sham",[26,32,35],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DEVICE","LIFUS - GPi Active","Bilateral thetaburst LIFUS stimulation to the globus pallidus",[9],null,{"type":27,"name":33,"description":16,"armGroupLabels":34,"otherNames":31},"LIFUS - DN Active",[15],{"type":27,"name":20,"description":36,"armGroupLabels":37,"otherNames":31},"Bilateral sham (placebo) LIFUS stimulation",[20],[39],{"name":40,"affiliation":5,"role":41},"Robert Chen, MD","PRINCIPAL_INVESTIGATOR",[43,48],{"name":44,"role":45,"phone":46,"phoneExt":31,"email":47},"Jean-Francois Nankoo, PhD","CONTACT","416-603-5792","jean-francois.nankoo@uhn.ca",{"name":49,"role":45,"phone":50,"phoneExt":51,"email":52},"Julian Kwok","416-603-5800","2708","julian.kwok@uhn.ca",[54],{"facility":55,"status":56,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"Toronto Western Hospital","RECRUITING","Toronto","Ontario","M5T 2S8","Canada","CA",{"type":63,"coordinates":64},"Point",[65,66],-79.39864,43.70643,{"lat":66,"lon":65},[69,70],{"name":49,"role":45,"phone":50,"phoneExt":51,"email":52},{"name":40,"role":41,"phone":31,"phoneExt":31,"email":31},{"type":72,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"SPONSOR_INVESTIGATOR","Robert Chen","Clinician Scientist","100646542","theta-burst-transcranial-focused-ultrasound-as-a-novel-treatment-for-cervical-dystonia-100646542",false,"NCT07690514","Theta Burst Transcranial Focused Ultrasound as a Novel Treatment for Cervical Dystonia","Inclusion Criteria:\n\n* 18 - 90 years of age\n* Confirmed diagnosis cervical dystonia\n* 3 months since last botulinum toxin injection\n* Stable medications in the past month\n\nExclusion Criteria:\n\n* Has neurological disorder other than dystonia (such as compressive neuropathy, limb trauma, epilepsy)\n* Cognitive deficits leading to inability to understand study purposes and risks as well as the consent information without legal trustee\n* Presence of metal implanted in body that is contraindicated in MRI\n* Pregnancy\n* Has a previous surgical intervention to treat CD such as lesioning or a DBS system in place\n* Major systemic illness or infection","ALL","18 Years","90 Years",{"count":85,"type":86},48,"ESTIMATED","INTERVENTIONAL",[89],"NA","This study is a single-blinded, randomized control study that aims to recruit 48 participants. Participants will be \"randomized\" into one of the study arms of the study: active stimulation to GPi, active stimulation to DN, or sham stimulation. The purpose of the study is to look into the effects of LIFUS in patients with cervical dystonia. The participation will include seven study visits, at least 24 hours apart. All study visits will take place at TWH. The first visit is a screening visit. Visits 2-6 will be on consecutive days. Visit 7 will be a week from Visit 6 or from your last day of LIFUS, whichever comes first.",[92],"Cervical Dystonia",[92],"2026-07-05",{"date":96,"type":97},"2026-07-08","ACTUAL",{"date":99,"type":97},"2024-11-18",{"date":101,"type":86},"2029-12",{"name":73,"class":6},1]