[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658240":3},{"organization":4,"outcomesModule":7,"designInfo":26,"detailedDescription":34,"studyPopulation":25,"armGroups":35,"interventions":53,"overallOfficials":25,"centralContacts":67,"locations":77,"responsibleParty":88,"collaborators":25,"id":90,"slug":91,"hasResults":92,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":25,"eligibilityCriteria":96,"healthyVolunteers":92,"sex":97,"minAge":98,"maxAge":99,"enrollmentInfo":100,"targetDuration":25,"studyType":103,"phases":104,"briefSummary":106,"conditions":107,"keywords":109,"overallStatus":113,"whyStopped":25,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"Damascus University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":25},[9],{"measure":10,"description":11,"timeFrame":12},"Change in probing pocket depth (PPD).","Probing pocket depth will be measured in millimeters from the free gingival margin to the base of the periodontal pocket using a UNC-15 periodontal probe at standardized sites.","Baseline to 3 months after the first treatment session.",[14,18,22],{"measure":15,"description":16,"timeFrame":17},"Change in Relative attachment level (RAL)","Relative attachment level (RAL) will be measured in millimeters from a standardized fixed reference point on a vacuum stent to the base of the periodontal pocket, measured using a UNC-15 periodontal probe.","from baseline to 3 months",{"measure":19,"description":20,"timeFrame":21},"Change in Gingival Recession (GR).","Gingival Recession (GR) will be measured in millimeters from the cementoenamel junction (CEJ) to the most apical point of the gingival margin, using a UNC-15 periodontal probe.","At baseline then 1 month and 3 months after the first session.",{"measure":23,"description":24,"timeFrame":21},"Change in Bleeding on Probing (BOP)","The presence or absence of bleeding following standardized periodontal probing to the base of the periodontal pocket. BOP will be recorded as a dichotomous outcome (present\u002Fabsent) at the selected periodontal sites, and the percentage of BOP-positive sites will be calculated at baseline and at each follow-up visit.",null,{"allocation":27,"interventionModel":28,"interventionModelDescription":25,"primaryPurpose":29,"observationalModel":25,"timePerspective":25,"maskingInfo":30},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":31,"maskingDescription":25,"whoMasked":32},"SINGLE",[33],"OUTCOMES_ASSESSOR","Several considerations support the need for this study. First, periodontal pockets are among the most common clinical manifestations of periodontal disease. There is also a need for effective treatment modalities that can complement the first-line approach of mechanical periodontal treatment, particularly in deep periodontal pockets and anatomically complex areas.\n\nAntimicrobial photodynamic therapy (aPDT) is an emerging and promising technology in dentistry; however, findings from studies worldwide regarding its superiority over mechanical treatment remain inconsistent. Furthermore, there is a lack of studies directly comparing aPDT using different laser wavelengths with conventional mechanical treatment. Therefore, the findings of this study may provide evidence to support the selection of a more effective treatment option for patients based on scientific evidence.",[36,42,47],{"label":37,"type":38,"description":39,"interventionNames":40},"Arm 1: 635 nm Diode Laser-Mediated aPDT + Non-Surgical Periodontal Treatment","EXPERIMENTAL","Participants will receive non-surgical periodontal treatment combined with antimicrobial photodynamic therapy (aPDT) using toluidine blue O activated by a 635 nm diode laser.",[41],"Other: 635 nm Diode Laser-Mediated aPDT + Non-Surgical Periodontal Treatment",{"label":43,"type":38,"description":44,"interventionNames":45},"Arm 2: 810 nm Diode Laser-Mediated aPDT + Non-Surgical Periodontal Treatment","Participants will receive non-surgical periodontal treatment combined with antimicrobial photodynamic therapy (aPDT) using toluidine blue O activated by an 810 nm diode laser.",[46],"Other: 810 nm Diode Laser-Mediated aPDT + Non-Surgical Periodontal Treatment",{"label":48,"type":49,"description":50,"interventionNames":51},"Arm 3: Non-Surgical Periodontal Treatment Alone (Control)","ACTIVE_COMPARATOR","Participants will receive non-surgical periodontal treatment alone, consisting of subgingival mechanical instrumentation using slim ultrasonic scaler tips, without photodynamic therapy.",[52],"Procedure: Non-Surgical Periodontal Treatment Alone (Control)",[54,58,62],{"type":6,"name":55,"description":56,"armGroupLabels":57,"otherNames":25},"635 nm Diode Laser-Mediated aPDT + Non-Surgical Periodontal Treatment","Participants assigned to this group will undergo non-surgical periodontal treatment with subgingival mechanical instrumentation using slim ultrasonic scaler tips. Antimicrobial photodynamic therapy will then be performed using toluidine blue O as the photosensitizing agent, activated by a 635 nm diode laser. The same treatment procedure will be repeated after two weeks.",[37],{"type":6,"name":59,"description":60,"armGroupLabels":61,"otherNames":25},"810 nm Diode Laser-Mediated aPDT + Non-Surgical Periodontal Treatment","Participants assigned to this group will undergo non-surgical periodontal treatment with subgingival mechanical instrumentation using slim ultrasonic scaler tips. Antimicrobial photodynamic therapy will then be performed using toluidine blue O as the photosensitizing agent, activated by an 810 nm diode laser. The same treatment procedure will be repeated after two weeks.",[43],{"type":63,"name":64,"description":65,"armGroupLabels":66,"otherNames":25},"PROCEDURE","Non-Surgical Periodontal Treatment Alone (Control)","Participants assigned to the control group will receive non-surgical periodontal treatment consisting of subgingival mechanical instrumentation using slim ultrasonic scaler tips. No photodynamic therapy or laser application will be performed.",[48],[68,73],{"name":69,"role":70,"phone":71,"phoneExt":25,"email":72},"SANA MAJALDEEN SALMAN, pursuing aMSc in periodontolog","CONTACT","00963936320891","sansoun.net@gmail.com",{"name":74,"role":70,"phone":75,"phoneExt":25,"email":76},"Wael HosamAldin Almahdi, DDS; MSc; PHD in periodontolog","00963933408906","wael2.mahdi@damascusuniversity.edu.sy",[78],{"facility":79,"status":25,"city":80,"state":25,"zip":25,"country":81,"countryCode":25,"cosmosGeoPoint":82,"geoPoint":87,"contacts":25},"The study will be conducted at the Faculty of Dentistry, Damascus University, Department of Periodontology, under the supervision of Professor Wael Al- Mahdi.","Damascus","Syria",{"type":83,"coordinates":84},"Point",[85,86],36.29128,33.5102,{"lat":86,"lon":85},{"type":89,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100658240","three-arm-randomized-clinical-trial-of-diode-laser-635-nm-and-810-nm-photodynamic-therapy-as-adjuncts-to-non-surgical-periodontal-treatment-100658240",false,"NCT07849647","Diode Laser 635 nm and 810 nm Photodynamic Therapy as Adjuncts to Non-Surgical Periodontal Treatment","Clinical Effectiveness of Diode Laser 635 nm and 810 nm Adjunctive Photodynamic Therapy Versus Mechanical Treatment in Non-Surgical Management of Periodontal Pockets (A Comparative Clinical Study).","Inclusion Criteria:\n\n* Adults aged 18 years or older (up to 65 years)\n* Participants diagnosed with Periodontitis Stage II-III according to the 2017 classification\n* Presence of at least 3 periodontal sites with a probing pocket depth (PPD) of ≥ 5 mm.\n* No periodontal treatment during the previous 6 months\n* Good general health\n\nExclusion Criteria:\n\n* Presence of systemic diseases or medical conditions that may affect periodontal status, wound healing, or the response to periodontal treatment.\n* Use of systemic antibiotics or other medications that may significantly affect periodontal treatment outcomes within the last 6 months.\n* Previous periodontal treatment within the last 6 months.\n* Known allergy or hypersensitivity to toluidine blue O or any material used in the study.\n* Pregnancy or breastfeeding.\n* Heavy smoking \\>10 units\u002Fday","ALL","18 Years","65 Years",{"count":101,"type":102},12,"ESTIMATED","INTERVENTIONAL",[105],"NA","This study aims to evaluate and compare the clinical effectiveness of antimicrobial photodynamic therapy (aPDT) using toluidine blue O (TBO) activated by two different diode laser wavelengths as an adjunct to non-surgical periodontal treatment in patients with Stage II and Stage III periodontitis. Participants will be randomly allocated to three treatment groups: non-surgical periodontal treatment combined with aPDT using a 635 nm diode laser, non-surgical periodontal treatment combined with aPDT using an 810 nm diode laser, and non-surgical periodontal treatment alone. The treatment outcomes will be evaluated based on changes in the following clinical periodontal parameters: Plaque Index (PI), Bleeding on Probing (BOP), Relative Attachment Level (RAL), Probing Depth (PD), and Gingival Recession (GR).",[108],"Periodontitis",[110,111,112],"periodontal therapy","photodynamic therapy","toluidine blue O","NOT_YET_RECRUITING","2026-10-02",{"date":116,"type":117},"2026-10-06","ACTUAL",{"date":119,"type":102},"2026-10",{"date":121,"type":102},"2027-05",{"name":5,"class":6},1]