[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100490219":3},{"organization":4,"outcomesModule":7,"designInfo":21,"detailedDescription":24,"studyPopulation":25,"armGroups":20,"interventions":26,"overallOfficials":20,"centralContacts":31,"locations":37,"responsibleParty":54,"collaborators":20,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":20,"enrollmentInfo":67,"targetDuration":20,"studyType":70,"phases":20,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":39,"whyStopped":20,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Chinese PLA General Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":16,"otherOutcomes":20},[9,13],{"measure":10,"description":11,"timeFrame":12},"Rate of Successful Recanalization","Antegrade blood flow through the recanalized portion was assessed by thrombolysis in myocardial infarction (TIMI) score or thrombolysis in cerebral infarction (TICI) score. TIMI≥2 or TICI≥2b was defined as successful recanalization.","1-3 Years",{"measure":14,"description":15,"timeFrame":12},"Ischemic Stroke Occurrence","Ischemic stroke occurrence during follow-up period which was confirmed by neuroimaging",[17],{"measure":18,"description":19,"timeFrame":12},"Number of Participants with Adverse Events","hemorrhagic or ischemic stroke after recanalization treatment",null,{"allocation":20,"interventionModel":20,"interventionModelDescription":20,"primaryPurpose":20,"observationalModel":22,"timePerspective":23,"maskingInfo":20},"COHORT","PROSPECTIVE","Cerebral ischemic stroke resulting from thrombosis causes high disability and mortality. There are few biomarkers to evaluate arterial thrombophilia until now. Previous studies have demonstrated that atherosclerotic plaque rupture and erosion are major etiologies initiating thrombosis. Based on previous works targeting the role of plaque and blood flow in cerebrovascular disease, in the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to explore the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment. The study's objective was to solve the challenges in the mechanism of thrombus features and the outcome of recanalization therapy, thus helping improve the primary and secondary prevention of cerebrovascular disease.","Participants who are confirmed to have extracranial and\u002For intracranial artery occlusion",[27],{"type":28,"name":29,"description":30,"armGroupLabels":20,"otherNames":20},"DIAGNOSTIC_TEST","thrombus imaging appearance","Imaging appearance of intracranial and\u002For extracranial arterial thrombus",[32],{"name":33,"role":34,"phone":35,"phoneExt":20,"email":36},"Jinhao Lyu, M.D.","CONTACT","+8615903562929","330322990@qq.com",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Beijing","Beijing Municipality","100853","China","CN",{"type":46,"coordinates":47},"Point",[48,49],116.39723,39.9075,{"lat":49,"lon":48},[52],{"name":53,"role":34,"phone":20,"phoneExt":20,"email":36},"Jinhao Lyu, MD",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Jinhao Lyu","Attending physician","100490219","thrombus-imaging-and-treatment-analytics-in-neurology-100490219",false,"NCT05663281","Thrombus Imaging and Treatment Analytics in Neurology","Titan","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Extracranial and\u002For intracranial artery occlusion confirmed by angiography\n* Available for magnetic resonance high-resolution vessel wall imaging\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Extracranial and\u002For intracranial artery mild to moderate stenosis\n* Pregnant women\n* Restenosis or occlusion after artery stenting placement","ALL","18 Years",{"count":68,"type":69},100,"ESTIMATED","OBSERVATIONAL","In the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to investigate the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment.",[73,74],"Thrombus, Brain","Thrombosis",[76,77,78,79,80],"Thrombus","Neuroimaging","High-resolution vessel wall imaging","Cerebral ischemia","Cerebral artery","2024-06-30",{"date":83,"type":84},"2024-07-03","ACTUAL",{"date":86,"type":84},"2022-12-15",{"date":88,"type":69},"2027-12-31",{"name":5,"class":6},1]