[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100656565":3},{"organization":4,"outcomesModule":7,"designInfo":33,"detailedDescription":36,"studyPopulation":37,"armGroups":38,"interventions":32,"overallOfficials":42,"centralContacts":49,"locations":32,"responsibleParty":55,"collaborators":32,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":32,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":32,"maxAge":67,"enrollmentInfo":68,"targetDuration":71,"studyType":72,"phases":32,"briefSummary":73,"conditions":74,"keywords":79,"overallStatus":85,"whyStopped":32,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":32},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":32},[9],{"measure":10,"description":11,"timeFrame":12},"Frequency of thyroid disorders","Number of participants with autoimmune hepatitis who have any thyroid disorder including overt or subclinical hypothyroidism, hyperthyroidism, or autoimmune thyroiditis based on thyroid function tests, autoantibodies, and ultrasonography","Baseline",[14,17,20,23,26,29],{"measure":15,"description":16,"timeFrame":12},"Pattern of thyroid disorders","Number of participants with specific thyroid disorders including Hashimoto thyroiditis, Graves disease, subclinical hypothyroidism, subclinical hyperthyroidism, and others",{"measure":18,"description":19,"timeFrame":12},"Thyroid autoantibody positivity","Number of participants with positive anti-thyroid peroxidase and\u002For anti-thyroglobulin antibodies",{"measure":21,"description":22,"timeFrame":12},"Thyroid ultrasonographic abnormalities","Proportion of children with abnormal thyroid ultrasound findings (enlargement, hypoechogenicity, nodules, or altered vascularity).",{"measure":24,"description":25,"timeFrame":12},"Serum TSH level","Mean serum thyroid-stimulating hormone (TSH) level (µIU\u002FmL).",{"measure":27,"description":28,"timeFrame":12},"Serum free T4 level","Mean serum free thyroxine (FT4) level (ng\u002FdL).",{"measure":30,"description":31,"timeFrame":12},"Serum free T3 level","Mean serum free triiodothyronine (FT3) level (pg\u002FmL).",null,{"allocation":32,"interventionModel":32,"interventionModelDescription":32,"primaryPurpose":32,"observationalModel":34,"timePerspective":35,"maskingInfo":32},"CASE_ONLY","CROSS_SECTIONAL","Autoimmune hepatitis is frequently associated with other autoimmune disorders, particularly autoimmune thyroid diseases. Thyroid dysfunction in children may remain asymptomatic yet affect growth and development.\n\nThis observational study will include children less than 18 years diagnosed with autoimmune hepatitis according to the Revised International Autoimmune Hepatitis Group (IAIHG) scoring system. All participants will undergo thyroid function tests (TSH, FT3, FT4), thyroid autoantibodies (anti-TPO, anti-Tg), and thyroid ultrasonography.","Children less than 18 years diagnosed with autoimmune hepatitis attending the Pediatric Hepatology Unit and Outpatient Clinic at Assiut University Children's Hospital.",[39],{"label":40,"type":32,"description":41,"interventionNames":32},"Single cohort: Children with autoimmune hepatitis","Children less than 18 years with autoimmune hepatitis who will undergo thyroid function tests, thyroid autoantibodies, and thyroid ultrasonography.",[43,47],{"name":44,"affiliation":45,"role":46},"Amal A seliman, prof","pediatrics Department, Assiut University Hospitals","STUDY_CHAIR",{"name":48,"affiliation":45,"role":46},"Shereen M Galal, Prof",[50],{"name":51,"role":52,"phone":53,"phoneExt":32,"email":54},"Arwa M Mohamed, Resident","CONTACT","+20 10 26065202","Arwa.18313343@med.aun.edu.eg",{"type":56,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","Arwa Alaaeldin Mohamed Ahmed","Resident Physician, Pediatrics","100656565","thyroid-disorders-in-pediatric-autoimmune-hepatitis-100656565",false,"NCT07827235","Thyroid Disorders in Pediatric Autoimmune Hepatitis","Frequency of Thyroid Disorders in Pediatric Patients With Autoimmune Hepatitis at Assiut University Children's Hospital","Inclusion Criteria:\n\n* Age less than 18 years\n* Diagnosis of autoimmune hepatitis according to the Revised International Autoimmune Hepatitis Group (IAIHG) scoring system\n* Written informed consent from parents or legal guardians\n\nExclusion Criteria:\n\n* \\- Previously diagnosed thyroid disorders before the diagnosis of autoimmune hepatitis\n* Medications known to interfere with thyroid function tests (other than corticosteroids or immunosuppressive therapy for AIH)\n* Chronic systemic diseases known to affect thyroid function independently of AIH\n* Other autoimmune disorders (celiac disease, diabetes, inflammatory bowel disease)\n* Refusal to participate","ALL","17 Years",{"count":69,"type":70},32,"ESTIMATED","1 Day","OBSERVATIONAL","This cross-sectional study aims to determine the frequency and spectrum of thyroid disorders among children with autoimmune hepatitis attending Assiut University Children's Hospital.",[75,76,77,78],"Thyroid Disease","Autoimmune Hepatitis","Hashimoto Thyroiditis","Graves Disease",[80,81,82,83,84],"Autoimmune hepatitis","Thyroid disorders","Anti-TPO","Pediatric","Assiut","NOT_YET_RECRUITING","2026-09-18",{"date":88,"type":89},"2026-09-22","ACTUAL",{"date":91,"type":70},"2026-09-15",{"date":93,"type":70},"2028-02-10",{"name":5,"class":6}]