[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658609":3},{"organization":4,"outcomesModule":7,"designInfo":27,"detailedDescription":29,"studyPopulation":30,"armGroups":31,"interventions":45,"overallOfficials":50,"centralContacts":62,"locations":69,"responsibleParty":85,"collaborators":26,"id":89,"slug":90,"hasResults":91,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":26,"eligibilityCriteria":95,"healthyVolunteers":96,"sex":97,"minAge":98,"maxAge":99,"enrollmentInfo":100,"targetDuration":26,"studyType":103,"phases":26,"briefSummary":104,"conditions":105,"keywords":107,"overallStatus":114,"whyStopped":26,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},{"fullName":5,"class":6},"Cairo University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":16,"otherOutcomes":26},[9,13],{"measure":10,"description":11,"timeFrame":12},"Tibialis Posterior Muscle Thickness","Tibialis posterior muscle thickness will be assessed using B-mode diagnostic ultrasonography with a high-frequency linear transducer. The ultrasound measurement site will be standardized at 30% of the shank length according to the predefined study protocol. Minimal transducer pressure will be applied to avoid muscle compression. Multiple images will be obtained, and the mean measurement will be used for statistical analysis.","Baseline assessment during a single study visit.",{"measure":14,"description":15,"timeFrame":12},"Tibialis Posterior Muscle Cross-sectional Area","Tibialis posterior muscle cross-sectional area will be assessed using B-mode diagnostic ultrasonography with a high-frequency linear transducer. The ultrasound measurement site will be standardized at 30% of the shank length according to the predefined study protocol. Minimal transducer pressure will be applied to avoid muscle compression. Multiple images will be obtained, and the mean cross-sectional area measurement will be used for statistical analysis.",[17,20,23],{"measure":18,"description":19,"timeFrame":12},"Tibialis Posterior Muscle Stiffness","Tibialis posterior muscle stiffness will be assessed using shear wave elastography (SWE) with an ultrasound system equipped with a high-frequency linear transducer. The ultrasound measurement site will be standardized at 30% of the shank length according to the predefined study protocol. Minimal transducer pressure will be applied to avoid muscle deformation. Multiple measurements will be obtained, and the mean stiffness value will be used for statistical analysis.",{"measure":21,"description":22,"timeFrame":12},"Foot Posture Index-6 (FPI-6)","Foot posture will be assessed using the Foot Posture Index-6 (FPI-6) during relaxed standing. The FPI-6 consists of six observational and palpation-based items used to assess foot posture, with each item scored from -2 to +2. The total score ranges from -12 to +12, with higher scores indicating a more pronated foot posture.",{"measure":24,"description":25,"timeFrame":12},"Pain intensity level","Pain intensity will be assessed using the Arabic version of the Numeric Pain Rating Scale (Arabic NPRS). Participants will rate their foot-related pain on a numerical scale from 0 to 10, where 0 indicates no pain and 10 indicates the worst pain imaginable. The Arabic NPRS will be administered according to its validated Arabic version.",null,{"allocation":26,"interventionModel":26,"interventionModelDescription":26,"primaryPurpose":26,"observationalModel":6,"timePerspective":28,"maskingInfo":26},"CROSS_SECTIONAL","Flexible flatfoot involves altered mechanics of the foot and may influence the functional demands placed on the structures responsible for maintaining the medial longitudinal arch. The tibialis posterior muscle is an important dynamic contributor to medial arch support and plays a role in controlling pronation and maintaining foot stability during functional activities.\n\nAlthough flexible flatfoot has been widely investigated from clinical and biomechanical perspectives, less is known about the morphological characteristics of the tibialis posterior muscle in relation to this condition. In particular, differences associated with the presence or absence of symptoms have not been sufficiently characterized. Evaluating muscle morphology may provide additional information about the muscular adaptations associated with altered foot posture.\n\nThe rationale for this study is to investigate whether the morphological characteristics of the tibialis posterior muscle differ across individuals with different clinical presentations of foot posture. Comparing these characteristics may help clarify whether muscular morphological changes are associated with flexible flatfoot itself or with the presence of symptoms.\n\nThe study findings may contribute to a better understanding of the muscular component of flexible flatfoot and provide information that may be useful for future research investigating assessment and rehabilitation strategies for individuals with this condition.","Participants will be recruited from individuals attending the outpatient clinics of the Faculty of Physical Therapy, Cairo University, and New Cairo Hospital. The study population will include individuals presenting with different foot postures, including those with flexible flatfoot and individuals with normal foot posture. Eligible participants who meet the study criteria and provide informed consent will be enrolled in the study.",[32,37,41],{"label":33,"type":26,"description":34,"interventionNames":35},"Symptomatic Flexible Flatfoot","Participants with flexible flatfoot who have foot-related symptoms.",[36],"Other: Tibialis Posterior Muscle Morphology Assessment",{"label":38,"type":26,"description":39,"interventionNames":40},"Asymptomatic Flexible Flatfoot","Participants with flexible flatfoot who do not have foot-related symptoms.",[36],{"label":42,"type":26,"description":43,"interventionNames":44},"Normal Foot Posture (Control)","Participants with normal foot posture who do not meet the study criteria for flexible flatfoot.",[36],[46],{"type":6,"name":47,"description":48,"armGroupLabels":49,"otherNames":26},"Tibialis Posterior Muscle Morphology Assessment","Assessment of tibialis posterior muscle morphology using B-mode diagnostic ultrasound as a non-invasive measurement method. The assessment is performed for research purposes and does not involve administration of treatment or modification of participants' usual care.",[38,42,33],[51,55,59],{"name":52,"affiliation":53,"role":54},"Nabil Abdo Abdellah Mohamed, PhD","Ass. Professor, Cairo University","STUDY_CHAIR",{"name":56,"affiliation":57,"role":58},"Hatem Mohamed Said El-Azizi, PhD","Professor, Cairo University","STUDY_DIRECTOR",{"name":60,"affiliation":61,"role":58},"Abdallah Mohamed Kamel, PhD","Lecturer, Cairo University",[63,68],{"name":64,"role":65,"phone":66,"phoneExt":26,"email":67},"Hend Ahmed, B.Sc","CONTACT","+201113097799","hendahmed63@gmail.com",{"name":60,"role":65,"phone":26,"phoneExt":26,"email":26},[70],{"facility":71,"status":26,"city":72,"state":26,"zip":26,"country":73,"countryCode":74,"cosmosGeoPoint":75,"geoPoint":80,"contacts":81},"Faculty of Physical Therapy, Cairo University Cairo, Egypt","Cairo","Egypt","EG",{"type":76,"coordinates":77},"Point",[78,79],31.24967,30.06263,{"lat":79,"lon":78},[82],{"name":83,"role":65,"phone":84,"phoneExt":26,"email":67},"Hend Ahmed Mansour Elhabyan, B.Sc","+20 11 13097799",{"type":86,"investigatorFullName":87,"investigatorTitle":88,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Hend Ahmed Mansour","Principal Investigator","100658609","tibialis-posterior-muscle-morphology-in-flexible-flatfeet-subjects-100658609",false,"NCT07854535","Tibialis Posterior Muscle Morphology in Flexible Flatfeet Subjects","Assessment of Tibialis Posterior Muscle Morphology in Subjects With Flexible Flatfeet","Inclusion Criteria:\n\n* Adults aged 18 to 40 years.\n* Both males and females will be eligible to participate.\n* Body mass index (BMI) ≤30 kg\u002Fm².\n* Participants with flexible flatfoot will demonstrate a visible medial longitudinal arch in the non-weight-bearing position and flattening of the arch during full weight-bearing.\n* Participants with flexible flatfoot will have a Foot Posture Index-6 (FPI-6) score of ≥+6.\n* Participants in the normal foot posture control group will have an FPI-6 score ranging from 0 to +5.\n* Participants must be able to stand and walk independently without an assistive device.\n* Participants must be willing to participate in the study and provide informed consent.\n\nExclusion Criteria:\n\n* History of previous surgery involving the foot, ankle, or lower limb.\n* History of significant trauma or fracture involving the foot, ankle, or lower limb.\n* Presence of rigid flatfoot or other structural foot deformities.\n* Presence of neurological disorders affecting the lower limb.\n* Presence of neuromuscular disorders affecting the lower limb.\n* Presence of systemic or inflammatory musculoskeletal conditions affecting the lower limb.\n* Current lower-limb injury or condition that may affect standing, walking, foot posture, or tibialis posterior muscle morphology.\n* Pregnancy.\n* Participants who are unable to follow the assessment procedures or complete the required study measurements.",true,"ALL","18 Years","40 Years",{"count":101,"type":102},45,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to assess tibialis posterior muscle morphology in adults with flexible flatfeet. The main question it aims to answer is:\n\nAre there differences in tibialis posterior muscle morphology between adults with symptomatic flexible flatfeet, asymptomatic flexible flatfeet, and individuals with normal foot posture?\n\nParticipants will undergo clinical assessment of foot posture and symptoms and an ultrasound assessment of the tibialis posterior muscle. The study will compare muscle thickness, cross-sectional area, and echo intensity among the three groups.",[106],"Flexible Flatfoot",[106,108,109,110,111,112,113],"Tibialis Posterior Muscle","Muscle Morphology","Ultrasound","Foot Posture","Muscle thickness","Muscle Cross sectional Area","NOT_YET_RECRUITING","2026-09-27",{"date":117,"type":118},"2026-10-02","ACTUAL",{"date":120,"type":102},"2026-10",{"date":122,"type":102},"2027-03",{"name":5,"class":6},1]