[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100656531":3},{"organization":4,"outcomesModule":7,"designInfo":16,"detailedDescription":15,"studyPopulation":15,"armGroups":24,"interventions":37,"overallOfficials":15,"centralContacts":15,"locations":43,"responsibleParty":62,"collaborators":66,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":74,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":15,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":15,"overallStatus":92,"whyStopped":15,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":15,"otherOutcomes":15},[9,13],{"measure":10,"description":11,"timeFrame":12},"Bone mineral density","measured by dual-energy X-ray absorptiometry","Baseline and 12 weeks",{"measure":14,"description":11,"timeFrame":12},"Bone mineral content",null,{"allocation":17,"interventionModel":18,"interventionModelDescription":15,"primaryPurpose":19,"observationalModel":15,"timePerspective":15,"maskingInfo":20},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":21,"maskingDescription":15,"whoMasked":22},"SINGLE",[23],"OUTCOMES_ASSESSOR",[25,31],{"label":26,"type":27,"description":28,"interventionNames":29},"Time-restricted eating combined with resistance exercise (TRE+Ex)","EXPERIMENTAL","Participants in the TRE+Ex group will be asked to fast for a target of 16 hours per day, consuming food ad libitum within an 8-hour eating window beginning between 6:30 and 9:30 AM, 6 days per week for 12 weeks. They will also complete supervised progressive resistance exercise training 3 days per week.",[30],"Behavioral: Time-restricted eating combined with resistance exercise (TRE+Ex)",{"label":32,"type":33,"description":34,"interventionNames":35},"Habitual eating pattern combined with resistance exercise (HE+Ex)","ACTIVE_COMPARATOR","Participants in the HE+Ex group will be instructed to maintain their habitual eating patterns and complete supervised progressive resistance exercise training 3 days per week.",[36],"Behavioral: Habitual eating pattern combined with resistance exercise (HE+Ex)",[38,41],{"type":39,"name":26,"description":28,"armGroupLabels":40,"otherNames":15},"BEHAVIORAL",[26],{"type":39,"name":32,"description":34,"armGroupLabels":42,"otherNames":15},[32],[44],{"facility":5,"status":15,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Birmingham","Alabama","35294","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-86.80249,33.52066,{"lat":54,"lon":53},[57],{"name":58,"role":59,"phone":60,"phoneExt":15,"email":61},"Yi Lin, PhD","CONTACT","205.996.5876","yilin@uabmc.edu",{"type":63,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":15,"oldOrganization":15},"PRINCIPAL_INVESTIGATOR","Yi Lin","Assistant Professor",[67,70],{"name":68,"class":69},"UAB Center for Exercise Medicine","UNKNOWN",{"name":71,"class":69},"UAB Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center","100656531","time-restricted-eating-and-exercise-for-bone-health-100656531",false,"NCT07824375","Time-Restricted Eating and Exercise for Bone Health","Time-Restricted Eating and Exercise Training to Enhance Bone Health in Adults With Osteopenia","OSTEO-FIT","Inclusion Criteria:\n\n* Men and women aged 50-75 years with body mass index (BMI) \\>25kg\u002Fm2\n* Osteopenia, defined as a T score between -1.0 and -2.5 at the lumbar spine, femoral neck, or total hip\n* Elevated adiposity, defined by waist circumference \\>102 cm in men or \\>88 cm in women\n* Stable health history over the past 2 months\n* Stable medication history over the past 2 months, as recommended by the primary provider\n* Willing and able to provide informed consent\n\nExclusion Criteria:\n\n* Participation in a formal weight loss program, intentional caloric restriction, fasting \\>10 hours\u002Fday, or ≥10 pounds weight loss within the past 3 months\n* Current participation in structured exercise training, supervised rehabilitation, or \\>150 minutes\u002Fweek of moderate intensity physical activity\n* Medical conditions or use of medications affecting bone metabolism\n* Diagnosed diabetes or use of insulin or glucose lowering medications\n* Resting heart rate \\>120 beats\u002Fminute or daytime blood pressure ≥180\u002F100 mmHg\n* Unstable angina, myocardial infarction, or stroke within the past 3 months\n* Continuous supplemental oxygen use for chronic pulmonary disease or heart failure\n* Rheumatoid arthritis, Parkinson's disease, dialysis, active cancer treatment within the past year, or diagnosed cognitive impairment\n* Absolute contraindications to exercise training according to American College of Sports Medicine guidelines\n* Unable to fast for 16 hours\n* Any condition that in the opinion of the investigator would impair ability to participate in the trial","ALL","50 Years","75 Years",{"count":84,"type":85},24,"ESTIMATED","INTERVENTIONAL",[88],"NA","The purpose of this study is to learn whether combining time-restricted eating with supervised resistance exercise can improve bone health in adults with osteopenia.",[91],"Osteopenia","NOT_YET_RECRUITING","2026-09-11",{"date":95,"type":96},"2026-09-17","ACTUAL",{"date":98,"type":85},"2026-11-01",{"date":100,"type":85},"2028-04-30",{"name":5,"class":6},1]