[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100510859":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":56,"centralContacts":64,"locations":72,"responsibleParty":101,"collaborators":104,"id":108,"slug":109,"hasResults":110,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":110,"sex":116,"minAge":117,"maxAge":118,"enrollmentInfo":119,"targetDuration":68,"studyType":122,"phases":123,"briefSummary":125,"conditions":126,"keywords":68,"overallStatus":74,"whyStopped":68,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":137},{"fullName":5,"class":6},"Bradley Hospital","OTHER",[8,15,20],{"label":9,"type":10,"description":11,"interventionNames":12},"ERP+iTBS","EXPERIMENTAL","Participants will receive two weeks (10 sessions) of intermittent theta burst stimulation (iTBS; a form of TMS) targeting the dorsolateral prefrontal cortex (dlPFC), followed immediately by Exposure Plus Response Prevention (ERP).",[13,14],"Device: Transcranial Magnetic Stimulation: intermittent theta burst to dorsolateral prefrontal cortex","Behavioral: Exposure with Response Prevention",{"label":16,"type":10,"description":17,"interventionNames":18},"ERP+cTBS","Participants will receive two weeks (10 sessions) of continuous theta burst stimulation (cTBS; a form of TMS) targeting the presupplementary motor area (pSMA), followed immediately by Exposure Plus Response Prevention (ERP).",[14,19],"Device: Transcranial Magnetic Stimulation: continuous theta burst to pre supplementary motor area",{"label":21,"type":22,"description":23,"interventionNames":24},"ERP+Sham","ACTIVE_COMPARATOR","Participants will receive two weeks (10 sessions) of sham (\"fake\") TMS, followed immediately by Exposure Plus Response Prevention (ERP).",[14,25],"Device: Transcranial Magnetic Stimulation: Sham",[27,36,46,51],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DEVICE","Transcranial Magnetic Stimulation: intermittent theta burst to dorsolateral prefrontal cortex","TMS will be delivered over the dorsolateral prefrontal cortex (dlPFC) using an intermittent bursting pattern",[9],[33,34,35],"TMS","Neuromodulation","iTBS",{"type":37,"name":38,"description":39,"armGroupLabels":40,"otherNames":41},"BEHAVIORAL","Exposure with Response Prevention","ERP will be delivered daily, immediately following TMS",[21,16,9],[42,43,44,45],"ERP","Exposure Therapy","Cognitive-Behavioral Therapy","CBT",{"type":28,"name":47,"description":48,"armGroupLabels":49,"otherNames":50},"Transcranial Magnetic Stimulation: Sham","Sham stimulation will use the Magstim sham air-cooled coil, which produces auditory signals and appears identical to an active coil but contains a mu-metal shield that diverts the majority of the magnetic flux such that a minimal (\\\u003C3%) magnetic field is delivered to the cortex",[21],[33,34],{"type":28,"name":52,"description":53,"armGroupLabels":54,"otherNames":55},"Transcranial Magnetic Stimulation: continuous theta burst to pre supplementary motor area","TMS will be delivered over the pre supplementary motor area (preSMA) using a continuous bursting pattern",[16],[33,35,34],[57,61],{"name":58,"affiliation":59,"role":60},"Kristen Benito, PhD","Emma Pendleton Bradley Hospital","PRINCIPAL_INVESTIGATOR",{"name":62,"affiliation":63,"role":60},"Christine Conelea, PhD","University of Minnesota",[65,70],{"name":58,"role":66,"phone":67,"phoneExt":68,"email":69},"CONTACT","410-432-1054",null,"kbenito@lifespan.org",{"name":62,"role":66,"phone":68,"phoneExt":68,"email":71},"cconelea@umn.edu",[73,89],{"facility":63,"status":74,"city":75,"state":76,"zip":77,"country":78,"countryCode":79,"cosmosGeoPoint":80,"geoPoint":85,"contacts":86},"RECRUITING","Minneapolis","Minnesota","55414","United States","US",{"type":81,"coordinates":82},"Point",[83,84],-93.26384,44.97997,{"lat":84,"lon":83},[87],{"name":62,"role":66,"phone":88,"phoneExt":68,"email":71},"612-261-3127",{"facility":59,"status":74,"city":90,"state":91,"zip":92,"country":78,"countryCode":79,"cosmosGeoPoint":93,"geoPoint":97,"contacts":98},"Riverside","Rhode Island","02915",{"type":81,"coordinates":94},[95,96],-71.36478,41.76732,{"lat":96,"lon":95},[99],{"name":58,"role":66,"phone":100,"phoneExt":68,"email":69},"401-432-1473",{"type":60,"investigatorFullName":102,"investigatorTitle":103,"investigatorAffiliation":5,"oldNameTitle":68,"oldOrganization":68},"Kristen Benito","Associate Professor (Research)",[105,106],{"name":63,"class":6},{"name":107,"class":6},"Butler Hospital","100510859","tms--exposure-therapy-for-pediatric-ocd-100510859",false,"NCT05931913","TMS + Exposure Therapy for Pediatric OCD","Transcranial Magnetic Stimulation to Augment Exposure and Response Prevention for Pediatric OCD","NExT","Inclusion Criteria:\n\n* Between the ages of 12 and 21 years.\n* Presence of OCD, as indicated by a score of \\> 16 on the Children's Yale-Brown Obsessive Compulsive Scale, indicating moderate or greater OCD symptoms.\n* Presence of motor compulsions on CY-BOCS compulsion checklist\n* English fluency to ensure comprehension of informed consent and study measures and instructions.\n\nExclusion Criteria:\n\n* Decline to provide informed consent.\n* Has a personal history, or a family history in a first-born relative, of any medical or psychiatric disorder, disease, condition, injury, symptoms or circumstance that, in the opinion of the principal investigator, may: (1) impact the risk profile of TMS; (2) reduce the subject's ability to fulfill the study requirements as per protocol; or (3) adversely impact the integrity of the data or the validity of the study results.\" Some examples include: epilepsy or seizure disorder(s), bipolar disorder or any psychiatric disorder associated with a risk of mania, intracranial pathology, traumatic brain injury, brain tumor, stroke, implanted medical devices or metallic objects in the head, or moderate-severe heart disease\n* Pregnant according to the medical history or a urine pregnancy test; and menstruating females who are heterosexually active and not using a highly effective form of contraception (tubal ligation, FDA-approved hormonal contraceptive, or an IUD)\n* Inability to undergo MRI.\n* Left handedness.\n* Is deemed to be at imminent risk of suicide according to the Ask Suicide-Screening Questions (ASQ) (i.e. answers YES to ≥ one (1) of the four screening questions) and\u002For in the medical opinion of the investigator\n* History of, or risk factors for, neurocardiogenic syncope (history of syncope\u002F presyncope related to noxious stimuli, anxiety, micturation, or posture).\n* Concurrent psychotherapy of any kind for OCD.\n* Concurrent TMS or receipt of any TMS experimental or clinical treatment less than 3 months prior to enrollment.\n* Taking a medication deemed to pose high seizurogenic potential per physician review\n* Taking a medication that has not reached stability criterion (same medication and dose for 6 weeks with no planned changes over the study period)","ALL","12 Years","21 Years",{"count":120,"type":121},60,"ESTIMATED","INTERVENTIONAL",[124],"NA","The goal of this clinical trial is to compare different forms of transcranial magnetic stimulation (TMS) for improving the outcomes of Exposure with Response Prevention (ERP) in youth and young adults with Obsessive-Compulsive Disorder (OCD). Researchers will compare three groups: ERP with one of two different active (\"real\") forms of TMS vs. ERP with sham (\"fake\") TMS. The main questions this study aims to answer are: 1) whether TMS normalizes functioning in brain circuits that contribute to compulsive behavior, and 2) whether TMS reduces compulsions during ERP. Participants will:\n\n* Complete clinical interviews, questionnaires, and computerized tasks\n* Complete two MRIs (brain scans)\n* Receive daily TMS followed by ERP for two weeks (10 sessions)",[127],"Obsessive-Compulsive Disorder","2026-08-19",{"date":130,"type":131},"2026-08-21","ACTUAL",{"date":133,"type":131},"2024-03-20",{"date":135,"type":121},"2029-10-31",{"name":5,"class":6},2]