[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100370063":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":32,"locations":37,"responsibleParty":54,"collaborators":11,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":11,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":11,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":40,"whyStopped":11,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"The First Affiliated Hospital with Nanjing Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"transanal endoscopic microsurgery followed by radiotherapy","EXPERIMENTAL",null,[13],"Procedure: transanal local excision following radiotherapy",{"label":15,"type":16,"description":11,"interventionNames":17},"total mesorectal excision","ACTIVE_COMPARATOR",[18],"Procedure: TME",[20,24],{"type":21,"name":22,"description":22,"armGroupLabels":23,"otherNames":11},"PROCEDURE","transanal local excision following radiotherapy",[9],{"type":21,"name":25,"description":26,"armGroupLabels":27,"otherNames":11},"TME","Total mesorectal excision",[15],[29],{"name":30,"affiliation":5,"role":31},"Yueming Sun, PhD","STUDY_DIRECTOR",[33],{"name":30,"role":34,"phone":35,"phoneExt":11,"email":36},"CONTACT","02568306026","jssym@vip.sina.com",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":11,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Colorectal Surgery Department, First Affiliated Hospital of Nanjing Medical University","RECRUITING","Nanjing","Jiangsu","China","CN",{"type":46,"coordinates":47},"Point",[48,49],118.77778,32.06167,{"lat":49,"lon":48},[52],{"name":53,"role":34,"phone":11,"phoneExt":11,"email":11},"Yueming Sun",{"type":55,"investigatorFullName":53,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Dr.","100370063","total-meso-rectal-excision-versus-transanal-local-excision-followed-by-radiotherapy-for-t2n0m0-distal-rectal-cancer-100370063",false,"NCT04098471","Total Meso-rectal Excision Versus Transanal Local Excision Followed by Radiotherapy for T2N0M0 Distal Rectal Cancer","Total Mesorectal Excision Versus Transanal Endoscopic Microsurgery Followed by Radiotherapy for T2N0M0 Distal Rectal Cancer: a Multicenter Randomized Trial","Inclusion Criteria:\n\n* Age between 18 and 75 years.\n* Histologically confirmed adenocarcinoma by preoperative biopsy.\n* Tumor located within 4 cm from the anal verge, confirmed by at least one of the following methods: digital rectal examination, pelvic magnetic resonance imaging (MRI), or colonoscopy.\n* Tumor size ≤3 cm, without fixation and with preserved mobility on clinical examination.\n* Clinical stage T2 rectal cancer confirmed by preoperative high-resolution pelvic MRI.\n* No radiological evidence of suspicious lymph node metastasis or distant metastasis on preoperative contrast-enhanced computed tomography (CT) and MRI.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* History of other malignant tumors within the past 5 years.\n* Poorly differentiated adenocarcinoma, mucinous adenocarcinoma, or signet ring cell carcinoma confirmed by pathological examination.\n* Multiple primary colorectal tumors.\n* Pregnant or breastfeeding women.\n* Patients with plans for pregnancy.\n* Severe psychiatric disorders.\n* Previous treatment for rectal cancer, including radiotherapy or chemotherapy.\n* Concomitant intestinal diseases, including familial adenomatous polyposis (FAP), hereditary nonpolyposis colorectal cancer (HNPCC), active ulcerative colitis, or Crohn's disease.\n* Poor general condition or uncontrolled serious comorbidities that may affect study participation or treatment.\n* Contraindications to laparoscopic surgery, including extensive intra-abdominal adhesions caused by previous abdominal surgery or inability to tolerate pneumoperitoneum.\n* Current participation in another clinical trial.","ALL","18 Years","75 Years",{"count":68,"type":69},168,"ESTIMATED","INTERVENTIONAL",[72],"NA","A randomized controlled clinical trial to compare the short and long term outcomes of transanal endoscopic microsurgery following radiotherapy or total mesorectal excision for the treatment of Rectal Cancer",[75],"Rectal Cancer",[77,78],"transanal endoscopic microsurgery","T2N0M0","2026-07-25",{"date":81,"type":82},"2026-07-28","ACTUAL",{"date":84,"type":82},"2021-10-01",{"date":86,"type":69},"2030-06-01",{"name":5,"class":6},1]