[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100656922":3},{"organization":4,"outcomesModule":7,"designInfo":25,"detailedDescription":24,"studyPopulation":24,"armGroups":30,"interventions":37,"overallOfficials":43,"centralContacts":50,"locations":55,"responsibleParty":88,"collaborators":91,"id":93,"slug":94,"hasResults":95,"nctId":96,"briefTitle":97,"officialTitle":97,"acronym":24,"eligibilityCriteria":98,"healthyVolunteers":95,"sex":99,"minAge":100,"maxAge":101,"enrollmentInfo":102,"targetDuration":24,"studyType":105,"phases":106,"briefSummary":107,"conditions":108,"keywords":110,"overallStatus":57,"whyStopped":24,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},{"fullName":5,"class":6},"Brigham and Women's Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":24},[9],{"measure":10,"description":11,"timeFrame":12},"Co-Contraction Interference Measure","Degree of co-contraction interference or crosstalk between RPNIs, modeled by fitting an exponential decay fit to task error over time or repetitions","from operative intervention to 12 months postop",[14,17,21],{"measure":15,"description":16,"timeFrame":12},"Task Performance Measure - Success Rate","Task success rate, measured by the mean squared error between intended and actual movement paths.",{"measure":18,"description":19,"timeFrame":20},"Task Performance Measure - Speed","Task completion speed, measured by the mean squared error between intended and actual movement","immediately post intervention to 12 months postop",{"measure":22,"description":23,"timeFrame":20},"Task Performance Measure - Participant Controllability","Participant controllability over task, measured by the mean squared error between intended and actual movement paths.",null,{"allocation":26,"interventionModel":27,"interventionModelDescription":24,"primaryPurpose":6,"observationalModel":24,"timePerspective":24,"maskingInfo":28},"NA","SINGLE_GROUP",{"masking":29,"maskingDescription":24,"whoMasked":24},"NONE",[31],{"label":32,"type":33,"description":34,"interventionNames":35},"Surgical Intervention - RPNI Construction","EXPERIMENTAL","Subjects undergoing the proposed operative intervention with associated follow up testing",[36],"Procedure: amputation or revision procedure with additional RPNI construction",[38],{"type":39,"name":40,"description":41,"armGroupLabels":42,"otherNames":24},"PROCEDURE","amputation or revision procedure with additional RPNI construction","amputation or revision procedure in which additional RPNIs (regenerative peripheral nerve interfaces) are created beyond what would be included in a standard care procedure",[32],[44,47],{"name":45,"affiliation":5,"role":46},"Matthew J Carty, MD","PRINCIPAL_INVESTIGATOR",{"name":48,"affiliation":49,"role":46},"Shriya Srinivasan, PhD","Harvard University",[51],{"name":45,"role":52,"phone":53,"phoneExt":24,"email":54},"CONTACT","617-983-4555","mcarty@bwh.harvard.edu",[56,71],{"facility":5,"status":57,"city":58,"state":59,"zip":60,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":69},"RECRUITING","Boston","Massachusetts","02115","United States","US",{"type":64,"coordinates":65},"Point",[66,67],-71.05977,42.35843,{"lat":67,"lon":66},[70],{"name":45,"role":52,"phone":53,"phoneExt":24,"email":54},{"facility":49,"status":72,"city":73,"state":59,"zip":74,"country":61,"countryCode":62,"cosmosGeoPoint":75,"geoPoint":79,"contacts":80},"NOT_YET_RECRUITING","Cambridge","02138",{"type":64,"coordinates":76},[77,78],-71.10561,42.3751,{"lat":78,"lon":77},[81,84,87],{"name":48,"role":52,"phone":82,"phoneExt":24,"email":83},"617-495-3675","shriya_srinivasan@fas.harvard.edu",{"name":85,"role":52,"phone":24,"phoneExt":24,"email":86},"Jennifer Leestma, PhD","jleestma@seas.harvard.edu",{"name":48,"role":46,"phone":24,"phoneExt":24,"email":24},{"type":46,"investigatorFullName":89,"investigatorTitle":90,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Matthew Carty","Roberta and Stephen R. Weiner Endowed Chair in Surgery, Brigham & Women's Hospital; Director, MGB Limb Restoration Research Initiative",[92],{"name":49,"class":6},"100656922","training-independent-muscle-activation-from-a-common-source-100656922",false,"NCT07831278","Training Independent Muscle Activation From a Common Source","Inclusion Criteria:\n\n* Age 18-65\n* Fluent in English\n* Approved for and scheduled to undergo acute amputation or revision amputation surgery (e.g. above-knee amputation with sciatic nerve ablation) OR sciatic nerve ablation for clinical indications (e.g. persistent pain, symptomatic neuroma, soft tissue breakdown, muscle atrophy, socket-related discomfort).\n* Willing and able to initiate participation within 14 days of surgery\n* Willing to perform at home studies\n* Possess adequate cognitive and communication abilities to describe their sensorimotor recovery during follow-up assessments\n* Demonstrate appropriate motivation and reliability to comply with scheduled training and evaluation sessions throughout the postoperative period\n* Able to travel to BWH\u002FBWFH and Harvard University for all required visits without lodging support\n\nExclusion Criteria:\n\n* • Passive or active metal implants incompatible with EMG\n\n  * Pacemakers, deep brain stimulators, or other electronic implantables\n  * Pregnancy or breastfeeding\n  * Current seizure disorder or other neurologically limiting conditions\n  * Cognitive or developmental disorders that limit task comprehension\n  * Vascular disorders impeding regeneration\n  * Known impairments in wound healing, including connective tissue disorders or under chronic systemic corticosteroid therapy\n  * Extensive peripheral neuropathies that may hinder neural regeneration and functional RPNI development\n  * Active smoker\n  * Are unable to provide informed consent\n  * Have a demonstrated history of poor protocol adherence\n  * Pregnant at the time of screening","ALL","18 Years","65 Years",{"count":103,"type":104},10,"ESTIMATED","INTERVENTIONAL",[26],"In this study, the investigators are evaluating a new surgical technique that may allow participants to control their muscles in a new way after their amputation or revision surgery. The investigators are looking for people who have limb amputation or require a revision operation to a previous amputation. Participants must be over 18 and younger than 65, willing to begin participation within two weeks of their surgery, and be willing to travel regularly to Boston.\n\nIn this study, participants will have a modified revision procedure on their amputated limb or a modified amputation procedure, followed by a series of follow up visits in clinic and to a gait lab at Harvard. Participants will also use a wearable device on their limb at home to complete daily training tasks and games.",[109],"Amputation",[111,112,113,114],"amputation","amputation revision","residual limb pain","phantom pain","2026-09-15",{"date":117,"type":118},"2026-09-21","ACTUAL",{"date":120,"type":104},"2026-09",{"date":122,"type":104},"2028-08-31",{"name":5,"class":6},2]