[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651949":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":19,"centralContacts":23,"locations":29,"responsibleParty":44,"collaborators":18,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":18,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":18,"enrollmentInfo":56,"targetDuration":18,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":68,"whyStopped":18,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Exercise Program","Participants will undergo a 6-month exercise program.",[12],"Other: Exercise",[14],{"type":6,"name":15,"description":16,"armGroupLabels":17,"otherNames":18},"Exercise","Supervised and structured strength and conditioning program",[9],null,[20],{"name":21,"affiliation":5,"role":22},"Peter Lee, MD, PhD","PRINCIPAL_INVESTIGATOR",[24],{"name":25,"role":26,"phone":27,"phoneExt":18,"email":28},"Peter J. Lee, MD, PhD","CONTACT","617-724-4000","plee22@mgh.harvard.edu",[30],{"facility":5,"status":18,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Boston","Massachusetts","02114","United States","US",{"type":37,"coordinates":38},"Point",[39,40],-71.05977,42.35843,{"lat":40,"lon":39},[43],{"name":21,"role":26,"phone":27,"phoneExt":18,"email":28},{"type":22,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Peter Lee","Principal Investigator","100651949","training-on-systemic-and-organ-spec-pm-in-pc-100651949",false,"NCT07768917","Training on Systemic and Organ Spec. PM in PC","Impact of Prescribed Physical Training on Systemic and Organ Specific Prognostic Markers in Prostate Cancer","Inclusion Criteria:\n\n* Have histologically or cytologically confirmed adenocarcinoma of the prostate\n* Have not received GnRH agonist or antagonist within the last 12 months\n* Planned for initiation of a GnRH agonist or antagonist or bilateral orchiectomy with an intended treatment duration of ≥ 6 months\n* Planned for initiation of radiation therapy to the prostate.\n* ECOG performance status of 0 or 1\n* Ability to understand and the willingness to sign a written informed consent document\n* Baseline serum total testosterone level \\> 230 ng\u002FdL (the accepted threshold for testosterone supplementation)\n* Speak English -\\>18 years of age\n\nExclusion Criteria:\n\n* Has a known medical condition that makes the subject unable to participate in exercise testing (e.g. unrevascularized coronary artery disease, moderate\u002Fsevere osteoarthritis, prior stroke, or other conditions)\n* Receiving or planned to receive other cancer therapy not included in Eligibility Criterion 3.1.3 (other than an antiandrogen during the first month of therapy)\n* The following populations will not be considered for inclusion on this trial.","ALL","18 Years",{"count":57,"type":58},20,"ESTIMATED","INTERVENTIONAL",[61],"NA","This research is being done to assess the impact of a supervised and structured strength and conditioning program on cardiac remodeling in participants with prostate cancer undergoing treatment with external beam radiation therapy and at least 6 months of Gonadotropin-releasing hormone (GnRH) therapy.",[64],"Prostate Cancer",[66,9,67],"Prescribed Physical Training","Systemic and Organ Specific Prognostic Markers in Prostate Cancer","NOT_YET_RECRUITING","2026-08-12",{"date":71,"type":72},"2026-08-17","ACTUAL",{"date":74,"type":58},"2026-12-10",{"date":76,"type":58},"2027-03-31",{"name":5,"class":6},1]