[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647436":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":24,"centralContacts":29,"locations":33,"responsibleParty":39,"collaborators":42,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":49,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":33,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":70,"overallStatus":79,"whyStopped":33,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":33},{"fullName":5,"class":6},"University of Las Palmas de Gran Canaria","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"tDCS Intervention","EXPERIMENTAL","Participants will receive 30 sessions of transcranial direct current stimulation applied over the left dorsolateral prefrontal cortex. Stimulation will be delivered at 2 mA for 20 minutes per session, once daily, five days per week, under supervision of trained healthcare professionals.",[13],"Device: Transcranial Direct Current Stimulation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Transcranial Direct Current Stimulation","Transcranial direct current stimulation will be delivered using a constant-current stimulator through surface electrodes placed over the scalp. The anode will be positioned over the left dorsolateral prefrontal cortex, corresponding to F3 according to the international 10-20 EEG system, and the cathode will be placed over the contralateral supraorbital region. Each session will be delivered at 2 mA for 20 minutes. Participants will complete 30 sessions.",[9],[21,22,23],"tDCS","Non-invasive brain stimulation","EPTE Bipolar tDCS device",[25],{"name":26,"affiliation":27,"role":28},"Juan Francisco Vigueras, MD","Canary Islands Health Service","PRINCIPAL_INVESTIGATOR",[30,35],{"name":26,"role":31,"phone":32,"phoneExt":33,"email":34},"CONTACT","+34 606 63 86 98",null,"juanfraviguerasperez@yahoo.es",{"name":36,"role":31,"phone":37,"phoneExt":33,"email":38},"David Morales Álamo, PhD","+34 623 062 814","david.moralesalamo@ulpgc.es",{"type":28,"investigatorFullName":40,"investigatorTitle":41,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"David Morales Álamo","Associate Professor",[43,45],{"name":44,"class":6},"Fundación Canaria Instituto de Investigación Sanitaria de Canarias",{"name":27,"class":46},"UNKNOWN","100647436","transcranial-direct-current-stimulation-for-long-covid-brain-fog-and-fatigue-100647436",false,"NCT07709234","Transcranial Direct Current Stimulation for Long COVID Brain Fog and Fatigue","The Impact of Transcranial Direct Current Stimulation on Quality of Life, Brain Fog, and Fatigue in Patients With Long COVID: Study Protocol of the NEUROSTIM-LC Study","NEUROSTIM-LC","Inclusion Criteria:\n\n* Adults aged between 18 and 70 years.\n* Diagnosis of long COVID according to World Health Organization criteria, defined as symptoms persisting for at least three months after acute SARS-CoV-2 infection and lasting for a minimum of two months without an alternative explanation.\n* Presence of persistent fatigue and\u002For cognitive impairment, commonly described as brain fog, attributed to long COVID and confirmed at screening.\n* Stable clinical condition allowing participation in the intervention and assessment procedures.\n* Ability to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Contraindications to transcranial direct current stimulation, including the presence of implanted electronic devices such as pacemakers or neurostimulators, intracranial metallic implants, or history of epilepsy or seizures.\n* History of neurological disorders that may affect cognitive function, including stroke, Parkinson's disease, or neurodegenerative disorders.\n* Pre-existing conditions associated with chronic fatigue or cognitive impairment prior to SARS-CoV-2 infection, such as fibromyalgia, chronic fatigue syndrome, or multiple sclerosis.\n* Severe psychiatric disorders, including psychosis or severe depression.\n* Substance abuse, including alcohol or drugs.\n* Current oncological treatment with chemotherapy or radiotherapy.\n* Pregnancy.\n* Any medical condition that, in the opinion of the investigators, may interfere with participation or with the interpretation of the results.","ALL","18 Years","70 Years",{"count":59,"type":60},20,"ESTIMATED","INTERVENTIONAL",[63],"NA","Long COVID can cause persistent symptoms such as fatigue, cognitive difficulties commonly described as brain fog, reduced exercise tolerance, and impaired quality of life. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that may help modulate brain activity in regions involved in cognition, fatigue, and executive function.\n\nThe NEUROSTIM-LC study will evaluate the feasibility and potential effects of repeated tDCS sessions in adults with long COVID presenting fatigue and\u002For brain fog. Participants will receive 30 sessions of tDCS applied over the left dorsolateral prefrontal cortex. Assessments will be performed before and after the intervention to evaluate changes in quality of life, fatigue, cognitive function, brain metabolism, physical performance, autonomic function, sleep quality, psychological symptoms, respiratory function, and blood biomarkers.",[66,67,68,69],"Long COVID","Post-COVID Conditions","Fatigue","Cognitive Dysfunction",[71,21,72,66,73,74,75,76,77,78],"Transcranial direct current stimulation","Brain fog","Chronic Fatigue","Quality of life","Cognitive impairment","Heart rate variability","PET-CT","Neuromodulation","NOT_YET_RECRUITING","2026-07-19",{"date":82,"type":83},"2026-07-22","ACTUAL",{"date":85,"type":60},"2026-09-15",{"date":87,"type":60},"2028-03-01",{"name":5,"class":6}]