[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647708":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":36,"centralContacts":40,"locations":27,"responsibleParty":49,"collaborators":27,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":53,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":27,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":27,"overallStatus":71,"whyStopped":27,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":27},{"fullName":5,"class":6},"Liv Hospital Vadistanbul","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard Rehabilitation Plus Active taVNS","EXPERIMENTAL","Participants will receive a standard rehabilitation program 5 days per week for 4 weeks. The program will include contrast baths, transcutaneous electrical nerve stimulation, heat therapy, desensitization techniques, passive and active range-of-motion exercises, strengthening, progressive loading, hand dexterity and coordination activities, and functional training. In addition, active transcutaneous auricular vagus nerve stimulation will be administered for 30 minutes per session, 5 days per week for 4 weeks, for a total of 20 sessions.",[13,14],"Device: Active Transcutaneous Auricular Vagus Nerve Stimulation","Other: Standard Rehabilitation Program",{"label":16,"type":17,"description":18,"interventionNames":19},"Standard Rehabilitation Plus Sham taVNS","SHAM_COMPARATOR","Participants will receive the same standard rehabilitation program 5 days per week for 4 weeks, including contrast baths, transcutaneous electrical nerve stimulation, heat therapy, desensitization techniques, passive and active range-of-motion exercises, strengthening, progressive loading, hand dexterity and coordination activities, and functional training. In addition, sham transcutaneous auricular vagus nerve stimulation will be administered for 30 minutes per session, 5 days per week for 4 weeks, for a total of 20 sessions, using a prespecified sham protocol not expected to produce therapeutic vagal stimulation.",[20,14],"Device: Sham Transcutaneous Auricular Vagus Nerve Stimulation",[22,28,32],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DEVICE","Active Transcutaneous Auricular Vagus Nerve Stimulation","Active transcutaneous auricular vagus nerve stimulation will be applied to the auricular concha region for 30 minutes per session, 5 days per week for 4 weeks, for a total of 20 sessions. Stimulation intensity will be individually adjusted to produce a tolerable paresthesia without pain. The intervention will be administered by a trained physiotherapist in addition to the standard rehabilitation program.",[9],null,{"type":23,"name":29,"description":30,"armGroupLabels":31,"otherNames":27},"Sham Transcutaneous Auricular Vagus Nerve Stimulation","Sham transcutaneous auricular vagus nerve stimulation will be administered using the same device, session duration, and treatment schedule as active taVNS: 30 minutes per session, 5 days per week for 4 weeks, for a total of 20 sessions. The electrode placement and\u002For stimulation parameters will be configured according to a prespecified sham protocol intended not to produce therapeutic vagal stimulation. The sham intervention will be administered by a trained physiotherapist in addition to the standard rehabilitation program.",[16],{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":27},"Standard Rehabilitation Program","All participants will receive the standard physical therapy and rehabilitation program routinely used in our clinic for patients with CRPS-I and based on current literature. The program will include contrast baths, transcutaneous electrical nerve stimulation, desensitization techniques, passive and active range-of-motion exercises, isometric and isotonic strengthening exercises, progressive loading exercises, hand dexterity and coordination activities, and functional training focused on activities of daily living. The rehabilitation program will be administered 5 days per week for 4 weeks.",[9,16],[37],{"name":38,"affiliation":5,"role":39},"Muhsin Doran","PRINCIPAL_INVESTIGATOR",[41,46],{"name":42,"role":43,"phone":44,"phoneExt":27,"email":45},"Muhsin Doran, MD","CONTACT","00905340807940","muhsin-doran@hotmail.com",{"name":47,"role":43,"phone":48,"phoneExt":27,"email":45},"muhsin doran, MD","00904444548",{"type":39,"investigatorFullName":38,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"Physical Medicine and Rehabilitation Specialist","100647708","transcutaneous-auricular-vagus-nerve-stimulation-added-to-rehabilitation-for-complex-regional-pain-syndrome-type-i-100647708",false,"NCT07711392","Transcutaneous Auricular Vagus Nerve Stimulation Added to Rehabilitation for Complex Regional Pain Syndrome Type I","Effectiveness of Transcutaneous Auricular Vagus Nerve Stimulation Added to Standard Rehabilitation in Patients With Complex Regional Pain Syndrome Type I: A Randomized Controlled Trial","taVNS-CRPS-I","Inclusion Criteria:\n\n* Diagnosis of complex regional pain syndrome type I according to the Budapest diagnostic criteria\n* Age 18 to 65 years\n* CRPS type I affecting the hand following a traumatic cause, including surgery, fracture, and\u002For immobilization of the hand or upper extremity\n* Willingness to participate in the study and provision of written informed consent\n\nExclusion Criteria:\n\n* Diagnosis of complex regional pain syndrome type II\n* CRPS type I developing after stroke\n* Acute or post-acute rehabilitation following hand tendon repair\n* Presence of a comorbid condition that may substantially affect functional status or health-related quality of life, including decompensated heart failure, chronic kidney failure, or malignancy\n* Arthritis affecting the hand\n* Acute arterial or venous thrombosis of the upper extremity\n* History of arterial or venous injury of the upper extremity","ALL","18 Years","65 Years",{"count":63,"type":64},20,"ESTIMATED","INTERVENTIONAL",[67],"NA","This randomized, participant- and assessor-blinded, sham-controlled study will evaluate the effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) added to standard rehabilitation in adults with complex regional pain syndrome type I (CRPS-I) affecting the hand or upper extremity.\n\nA total of 20 participants will be randomly assigned to two parallel groups. Both groups will receive the same standard rehabilitation program 5 days per week for 4 weeks. In addition, the experimental group will receive active taVNS, while the control group will receive sham taVNS for 30 minutes per session over the same 4-week period.\n\nThe primary outcome is change in pain intensity measured using the Numerical Rating Scale. Secondary outcomes include CRPS clinical severity, hand and wrist circumference, hand function and activities of daily living, health-related quality of life, anxiety and depression symptoms, and perceived stress. Assessments will be performed at baseline, at the end of treatment at week 4, and during follow-up at weeks 8 and 12.",[70],"Complex Regional Pain Syndrome Type I","NOT_YET_RECRUITING","2026-07-14",{"date":74,"type":75},"2026-07-17","ACTUAL",{"date":77,"type":64},"2026-07-15",{"date":79,"type":64},"2027-02-15",{"name":5,"class":6}]