[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638035":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":11,"centralContacts":20,"locations":26,"responsibleParty":44,"collaborators":11,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":11,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":11,"enrollmentInfo":57,"targetDuration":11,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":11,"overallStatus":28,"whyStopped":11,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"Brigham and Women's Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Rosacea","EXPERIMENTAL",null,[13],"Device: Transaricular vagus nerve stimulation (taVNS)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"DEVICE","Transaricular vagus nerve stimulation (taVNS)","This project consists of a 4-week trial of transaricular vagus nerve stimulation (taVNS) for rosacea. Participation is expected to last for a total duration of 8 weeks (4 week active intervention period)",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":11,"email":25},"Liset Chacin","CONTACT","617-264-5926","lchacin@bwh.harvard.edu",[27],{"facility":5,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"RECRUITING","Boston","Massachusetts","02461","United States","US",{"type":35,"coordinates":36},"Point",[37,38],-71.05977,42.35843,{"lat":38,"lon":37},[41],{"name":42,"role":23,"phone":24,"phoneExt":11,"email":43},"John Barbieri, MD, MBA","jbarbieri@bwh.harvard.edu",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","John Barbieri","Clinician Investigator, Associate Professor of Dermatology","100638035","transcutaneous-auricular-vagus-nerve-stimulation-treatment-for-rosacea-100638035",false,"NCT07600424","Transcutaneous Auricular Vagus Nerve Stimulation Treatment for Rosacea","Transcutaneous Auricular Vagus Nerve Stimulation Treatment for Rosacea: A Pilot Trial","Inclusion Criteria:\n\n* Adults aged 18 years of age and older\n* Dermatologist confirmed diagnosis of rosacea\n* Clinician's Erythema Assessment of at least 3 (moderate to severe disease)\n* Willingness to adhere to current rosacea regimen without additions or laser treatments (e.g. PDL) during the study period.\n\nExclusion Criteria:\n\n* Changes to rosacea regimen (prescription topical or oral medications) within 4 weeks of randomization.\n* Facial hair, tattoos, or other characteristics that would interfere with erythema assessments\n* History of symptomatic cardiac arrythmias (e.g. heart block, sick sinus syndrome, bradyarrhythmia)\n* Presence of a pacemaker, implanted defibrillator, or neurostimulator\n* Seizure disorder or epilepsy\n* Trigeminal Neuralgia within the past year\n* Severe coronary disease or recent myocardial infarction within the past 5 years\n* Severe autonomic dysfunction (e.g., frequent syncope, hospitalization)\n* History of recurrent syncope or unexplained fainting\n* Use of brimonidine or oxymetazoline within the past 4 weeks\n* Use of beta-blockers, anticholinergics, or vagal-modulating drugs within the past 4 weeks\n* Severe phymatous rosacea\n* Ear deformity, piercings, or other condition that prevents the use of the taVNS device\n* Known hypersensitivity to electrode materials\n* Patients who are pregnant.","ALL","18 Years",{"count":58,"type":59},10,"ESTIMATED","INTERVENTIONAL",[62],"NA","A single arm, pilot study among individuals with rosacea and at least moderate flushing or rednesss will be enrolled in a 4-week trial of taVNS. The particicpants will be followed for an additional 4-weeks following the intervention period to evaluate the durability of the results",[9,65,66],"Rosacea, Erythematotelangiectatic","Flushing","2026-08-12",{"date":69,"type":70},"2026-08-14","ACTUAL",{"date":72,"type":70},"2026-05-23",{"date":74,"type":59},"2028-02-28",{"name":5,"class":6},1]