[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100657311":3},{"organization":4,"outcomesModule":7,"designInfo":26,"detailedDescription":16,"studyPopulation":16,"armGroups":35,"interventions":48,"overallOfficials":16,"centralContacts":59,"locations":65,"responsibleParty":83,"collaborators":16,"id":87,"slug":88,"hasResults":89,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":89,"sex":95,"minAge":96,"maxAge":16,"enrollmentInfo":97,"targetDuration":16,"studyType":100,"phases":101,"briefSummary":103,"conditions":104,"keywords":106,"overallStatus":68,"whyStopped":16,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},{"fullName":5,"class":6},"Cairo University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":16},[9],{"measure":10,"description":11,"timeFrame":12},"Change in Probing Depth (PD)","Change in periodontal probing depth (PD), measured in millimeters using a UNC-15 periodontal probe with a standardized probing force. Measurements are obtained using a patient-specific acrylic stent to ensure reproducibility.","Baseline and 6 months after treatment",[14,18,20,22],{"measure":15,"description":16,"timeFrame":17},"Clinical Attachment Level (CAL)",null,"Baseline, 3 months, and 6 months after treatment",{"measure":19,"description":16,"timeFrame":17},"Change in Gingival Recession (GR) measured using a UNC-15 periodontal probe",{"measure":21,"description":16,"timeFrame":12},"Change in Radiographic Intrabony Defect Depth measured using standardized periapical radiographs and ImageJ software",{"measure":23,"description":24,"timeFrame":25},"Patient Satisfaction (VAS)","0 indicates no pain or discomfort and 10 indicates the worst imaginable pain or discomfort.","During the first postoperative week after treatment",{"allocation":27,"interventionModel":28,"interventionModelDescription":16,"primaryPurpose":29,"observationalModel":16,"timePerspective":16,"maskingInfo":30},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":31,"maskingDescription":16,"whoMasked":32},"DOUBLE",[33,34],"PARTICIPANT","OUTCOMES_ASSESSOR",[36,42],{"label":37,"type":38,"description":39,"interventionNames":40},"MINST Alone","ACTIVE_COMPARATOR","Participants will receive modified minimally invasive non-surgical periodontal therapy (MINST) alone. The procedure will be performed under local anesthesia using piezoelectric ultrasonic instruments with thin tips and magnification loupes while preserving root cementum and minimizing soft tissue trauma. No platelet-rich fibrin or other regenerative biomaterial will be applied.",[41],"Procedure: Modified Minimally Invasive Non-Surgical Technique (MINST)",{"label":43,"type":44,"description":45,"interventionNames":46},"MINST + Extended Platelet-Rich Fibrin (e-PRF)","EXPERIMENTAL","Participants will receive modified minimally invasive non-surgical periodontal therapy (MINST) followed by the application of autologous extended platelet-rich fibrin (e-PRF) into the intrabony periodontal defect. MINST will be performed under local anesthesia using piezoelectric ultrasonic instruments with thin tips and magnification loupes while preserving root cementum and minimizing soft tissue trauma. The e-PRF will be prepared from the participant's peripheral blood by combining heated albumin gel with liquid platelet-rich fibrin before placement into the defect. The protocol follows the procedures described in the study protocol",[47,41],"Biological: Extended Platelet-Rich Fibrin (e-PRF)",[49,54],{"type":50,"name":51,"description":52,"armGroupLabels":53,"otherNames":16},"BIOLOGICAL","Extended Platelet-Rich Fibrin (e-PRF)","Autologous extended platelet-rich fibrin (e-PRF) prepared from the participant's peripheral blood. Whole blood is centrifuged to obtain liquid platelet-rich fibrin, while the platelet-poor plasma is heated to form denatured albumin gel. The cooled albumin gel is mixed with the liquid platelet-rich fibrin to produce e-PRF, which is applied into the periodontal intrabony defect immediately after completion of the MINST procedure",[43],{"type":55,"name":56,"description":57,"armGroupLabels":58,"otherNames":16},"PROCEDURE","Modified Minimally Invasive Non-Surgical Technique (MINST)","Modified minimally invasive non-surgical periodontal therapy performed under local anesthesia using piezoelectric ultrasonic instruments with thin tips and magnification loupes. The procedure aims to thoroughly debride the periodontal pocket while minimizing soft tissue trauma and preserving root cementum by avoiding intentional root surface smoothing and gingival curettage.",[43,37],[60],{"name":61,"role":62,"phone":63,"phoneExt":16,"email":64},"Samuel Michael Mikhail, B.Sc.","CONTACT","+201117776200","samuel.girgis@dentistry.cu.edu.eg",[66],{"facility":67,"status":68,"city":69,"state":70,"zip":71,"country":72,"countryCode":73,"cosmosGeoPoint":74,"geoPoint":79,"contacts":80},"Faculty of Dentistry, Cairo University","RECRUITING","Giza","Giza Governorate","12613","Egypt","EG",{"type":75,"coordinates":76},"Point",[77,78],31.20861,30.00944,{"lat":78,"lon":77},[81],{"name":82,"role":62,"phone":63,"phoneExt":16,"email":64},"Samuel Mikhail, B.Sc.",{"type":84,"investigatorFullName":85,"investigatorTitle":86,"investigatorAffiliation":5,"oldNameTitle":16,"oldOrganization":16},"PRINCIPAL_INVESTIGATOR","Samuel Michael Mikhail","Principal Investigator, Postgraduate Researcher in periodontology","100657311","treating-intrabony-defect-with-minst-vs-minst-extended-prf-100657311",false,"NCT07836231","Treating Intrabony Defect With MINST VS MINST Extended PRF","Clinical Effectiveness of Minimally Invasive Non-surgical Technique With or Without Extended Platelets Rich Fibrin in Intrabony Defects: a Randomized Controlled Clinical Trial","MINST PRF","Inclusion Criteria:\n\nAdults aged above 21 years. Clinical diagnosis of Stage III periodontitis. Presence of at least two isolated interproximal intrabony defects located in different quadrants.\n\nIntrabony defect associated with a single-rooted tooth or mandibular molar without furcation involvement.\n\nProbing depth (PD) ≥ 6 mm. Radiographic intrabony defect depth between 3 and 7 mm. Absence of periapical pathology at the study site. Absence of acute periodontal infection. Absence of subgingival restorations that could interfere with clinical measurements.\n\nAbsence of Grade II or Grade III tooth mobility. Ability and willingness to provide written informed consent.\n\nExclusion Criteria:\n\nPregnancy or lactation. Non-surgical periodontal therapy within the previous 6 months. Surgical periodontal therapy within the previous 12 months. History of radiotherapy to the head and neck region. Current smoking.\n\nEligibility note: Former smokers and never-smokers are eligible.","ALL","18 Years",{"count":98,"type":99},48,"ESTIMATED","INTERVENTIONAL",[102],"NA","This study evaluates a minimally invasive non-surgical technique (MINST) for treating periodontal intrabony defects, with or without the addition of Extended Platelet-Rich Fibrin (e-PRF). The goal is to determine which approach provides better bone regeneration and gum healing.\n\nStudy Procedures\n\nControl Group:\n\nLocal anesthesia by infiltration at the treatment site\n\nInstrumentation of the root surface up to the bottom of the periodontal pocket\n\nEfforts are made to minimize trauma to soft tissues and interdental papilla using subpapillary access\n\nCleaning is performed using piezo-electric devices with delicate tips, avoiding aggressive root smoothing or gingival curettage\n\n3-4× magnification loupes are used to improve precision\n\nIntervention Group:\n\nAll the above procedures\n\nFollowed by injection of e-PRF, a preparation derived from the patient's own blood\n\nBlood is collected in 4 mL tubes and centrifuged at 700 g for 8 minutes\n\nThe platelet-poor plasma is heated to create an albumin gel\n\nThe remaining buffy coat (rich in platelets and growth factors) is mixed with the cooled albumin gel to form Alb-PRF, which is applied to the defect",[105],"Periodontal Intrabony Defects",[107,108,51,109,110],"Periodontal intrabony defects","Minimally invasive non-surgical technique (MINST)","Alb-PRF","Periodontal regeneration","2026-09-19",{"date":113,"type":114},"2026-09-23","ACTUAL",{"date":116,"type":114},"2026-05-26",{"date":118,"type":99},"2027-07-01",{"name":5,"class":6},1]