[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100503776":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":27,"locations":38,"responsibleParty":73,"collaborators":76,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":81,"sex":87,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":26,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":26,"overallStatus":41,"whyStopped":26,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"James J. Peters Veterans Affairs Medical Center","FED",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Study 1","EXPERIMENTAL","Twenty-five participants will be asked to visit the laboratory on 6 occasions, for an open-label, dose escalation trial to determine the effect of midodrine and droxidopa on supine and seated blood pressure and on symptoms of autonomic dysreflexia and orthostatic hypotension.",[13],"Drug: Midodrine Hydrochloride",{"label":15,"type":10,"description":16,"interventionNames":17},"Study 2","Determine the effects of compression garments, midodrine, and droxidopa, compared to placebo, on orthostatic hemodynamics, symptoms of AD and OH and reporting of fatigue and thermal comfort.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Midodrine Hydrochloride","Determine best drug and dose to increase and stabilize SBP during orthostatic tilt",[9,15],[25],"Droxidopa",null,[28,33],{"name":29,"role":30,"phone":31,"phoneExt":26,"email":32},"Matt T Maher, MS","CONTACT","9733243588","matthew.maher@va.gov",{"name":34,"role":30,"phone":35,"phoneExt":36,"email":37},"Dylan C Arnero, MA","718-584-9000","5124","dylan.arnero@va.gov",[39,58],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Kessler Foundation","RECRUITING","West Orange","New Jersey","07052","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-74.23904,40.79871,{"lat":51,"lon":50},[54],{"name":55,"role":30,"phone":56,"phoneExt":26,"email":57},"Matthew T Maher, MS","201-566-0291","MMaher@Kesslerfoundation.org",{"facility":59,"status":41,"city":60,"state":61,"zip":62,"country":45,"countryCode":46,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"James J Peters VA Medical Center","The Bronx","New York","10468",{"type":48,"coordinates":64},[65,66],-73.86641,40.84985,{"lat":66,"lon":65},[69,70],{"name":34,"role":30,"phone":35,"phoneExt":36,"email":37},{"name":71,"role":72,"phone":26,"phoneExt":26,"email":26},"Jill M Wecht, EdD","PRINCIPAL_INVESTIGATOR",{"type":72,"investigatorFullName":74,"investigatorTitle":75,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Jill M. Wecht, Ed.D.","Research Scientist",[77],{"name":40,"class":78},"OTHER","100503776","treatment-of-orthostatic-hypotension-in-sci-100503776",false,"NCT05839652","Treatment of Orthostatic Hypotension in SCI","Treatment of Orthostatic Hypotension in Individuals With Spinal Cord Injury","SCI","Inclusion Criteria:\n\n* traumatic spinal cord injury\n* at least 12 months post injury\n* injury level of C1-T6\n* AIS A, B or C\n* non-ambulatory\n* non-ventilator\n\nExclusion Criteria:\n\n* Active psychiatric disorder\n* Stroke or cerebrovascular disease\n* Alzheimer's Disease or dementia\n* Unmanaged cardiac arrhythmias\n* Concurrent systemic, hepatic, or renal disease\n* Suspected or diagnosed malignancy\n* Neurological disease other than SCI\n* Self-reported history of three or more symptomatic episodes of AD per day","ALL","18 Years","60 Years",{"count":91,"type":92},25,"ESTIMATED","INTERVENTIONAL",[95],"PHASE4","The purpose of this study is to identify the effects of non-pharmacological and pharmacological anti-hypotensive treatment interventions on orthostatic hemodynamic responses, symptoms of autonomic dysreflexia and orthostatic hypotension, and levels of fatigue and comfort in hypotensive individuals with SCI.",[98],"Hypotension","2026-08-06",{"date":101,"type":102},"2026-08-10","ACTUAL",{"date":104,"type":102},"2023-07-01",{"date":106,"type":92},"2027-06-30",{"name":5,"class":6},2]