[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100604795":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":45,"centralContacts":49,"locations":54,"responsibleParty":71,"collaborators":40,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":40,"eligibilityCriteria":79,"healthyVolunteers":75,"sex":80,"minAge":81,"maxAge":40,"enrollmentInfo":82,"targetDuration":40,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":40,"overallStatus":94,"whyStopped":40,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Shanghai Mental Health Center","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Closed-loop Group","EXPERIMENTAL","Participants in this arm will receive closed-loop TMS.\n\nBefore stimulation:\n\nThe researchers measure the participant's Resting Motor Threshold (RMT) and assess their craving using VAS before and after view a methamphetamine-related video.\n\nThe participants complete SST.\n\nDuring the stimulation phase, participants will:\n\nFirst undergo a training phase, during which EEG will be recorded while they perform a cue-reactivity task to identify neural signatures and calculate stimulation thresholds.\n\nThen perform the cue-reactivity task again, and real-time EEG features will be used to trigger TMS in a closed-loop mode.\n\nAfter the stimulation, participants will:\n\nThe researchers again assess their craving using VAS before and after viewing the video.\n\nThe participants again complete the SST. The researchers record adverse reactions and adverse events, and evaluate the blinding effect, through a Blinding Assessment Questionnaire.",[13],"Device: Closed-loop TMS",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional TMS Group","ACTIVE_COMPARATOR","Participants in this arm will receive conventional TMS.\n\nBefore stimulation:\n\nThe researchers measure the participant's RMT and assess their craving using VAS before and after view a methamphetamine-related video.\n\nThe participants complete SST.\n\nDuring the stimulation phase, participants will:\n\nFirst undergo a training phase, during which EEG will be recorded while they perform a cue-reactivity task to identify neural signatures and calculate stimulation thresholds.\n\nThen receive a TMS treatment delivered at a conventional iTBS protocol, and perform perform the cue-reactivity task again afterwards.\n\nAfter the stimulation, participants will:\n\nThe researchers again assess their craving using VAS before and after viewing a methamphetamine-related video.\n\nThe participants again complete the SST. The researchers record adverse reactions and adverse events, and evaluate the blinding effect, through a Blinding Assessment Questionnaire.",[19],"Device: Conventional TMS",{"label":21,"type":22,"description":23,"interventionNames":24},"Sham Group","SHAM_COMPARATOR","Participants in this arm will receive random TMS.\n\nBefore stimulation:\n\nThe researchers measure the participant's Resting Motor Threshold (RMT) and assess their craving using VAS before and after view a methamphetamine-related video.\n\nThe participants complete SST.\n\nDuring the stimulation phase, participants will:\n\nFirst undergo a training phase, during which EEG will be recorded while they perform a cue-reactivity task to identify neural signatures and calculate stimulation thresholds.\n\nThen perform the cue-reactivity task again, TMS will be triggered by a random sequence unrelated to real-time EEG features.\n\nAfter the stimulation, participants will:\n\nThe researchers again assess their craving using VAS before and after viewing a methamphetamine-related video.\n\nThe participants again complete the SST. The researchers record adverse reactions and adverse events, and evaluate the blinding effect, through a Blinding Assessment Questionnaire.",[25],"Device: Random TMS",[27,36,41],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DEVICE","Closed-loop TMS","Participants receive theta burst stimulation (TBS), triggered by real-time EEG signals recorded during a cue-reactivity task. This closed-loop protocol aims to deliver stimulation precisely during neural states associated with cue-induced craving.",[9],[33,34,35],"EEG-TMS","Closed-loop TBS","EEG triggered TMS",{"type":28,"name":37,"description":38,"armGroupLabels":39,"otherNames":40},"Conventional TMS","Participants receive TBS, delivered at a standard iTBS protocol (3-pulse 50-Hz bursts given at every 200 ms (i.e. at 5 Hz), 2s on and 8s off, with 1200 pulses in total), without EEG or task engagement.",[15],null,{"type":28,"name":42,"description":43,"armGroupLabels":44,"otherNames":40},"Random TMS","Participants receive TBS, triggered by a random sequence unrelated to real-time EEG features.",[21],[46],{"name":47,"affiliation":5,"role":48},"Min Zhao, PhD","STUDY_CHAIR",[50],{"name":47,"role":51,"phone":52,"phoneExt":40,"email":53},"CONTACT","+86 18017311005","drminzhao@smhc.org.cn",[55],{"facility":56,"status":40,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"Shanghai Mental Health Center, 200030","Shanghai","Shanghai Municipality","200000","China","CN",{"type":63,"coordinates":64},"Point",[65,66],121.45806,31.22222,{"lat":66,"lon":65},[69],{"name":47,"role":51,"phone":70,"phoneExt":40,"email":53},"18017311005",{"type":72,"investigatorFullName":40,"investigatorTitle":40,"investigatorAffiliation":40,"oldNameTitle":40,"oldOrganization":40},"SPONSOR","100604795","trial-of-device-that-is-not-approved-or-cleared-by-the-us-fda-100604795",false,"NCT07154160","Closed-loop TMS for the Core Clinical Features of the Methamphetamine Use Disorder","A Single-blind, Randomized, Parallel Study of Closed-loop, Conventional and Random TMS for Core Clinical Features of Methamphetamine Use Disorder.","Inclusion Criteria:\n\nAged 18 years old or older, ....with at least 9 years of education (junior high school or above) or able to fully understand the task.\n\nMeets DSM-5 for mild\u002Fsevere amphetamine-type substance use disorder. History of amphetamine-type substance use for no less than 1 year, with use at least once per week.\n\nHas not received pharmacological treatment for substance use.\n\nExclusion Criteria:\n\nPresence of any organic disease, or diagnosis of any other psychiatric disorder according to DSM-5 (e.g., bipolar disorder, major depression disorder).\n\nContraindications to TMS, as assessed by the Transcranial Magnetic Stimulation Adult Safety Screen (TASS).\n\nInability to complete assessments, treatment procedures, or follow-up due to cognitive or behavioral limitations.","ALL","18 Years",{"count":83,"type":84},21,"ESTIMATED","INTERVENTIONAL",[87],"NA","The goal of this clinical trial is to evaluate whether closed-loop transcranial magnetic stimulation (TMS) can improve core clinical symptoms in individuals with methamphetamine use disorder (MUD), such as cue-reactivity and impaired inhibitory control.\n\nThe main questions it aims to answer are:\n\nCan closed-loop TMS significantly reduce cue-reactivity, as measured by a Visual Analog Scale (VAS) and cue-reactivity task, compared to a conventional treatment protocol and random TMS ? Does closed-loop stimulation enhance cognitive control, assessed by performance on the Stop Signal Task (SST), more effectively than the other stimulation modes? Researchers will compare closed-loop, conventional, and random TMS conditions to determine whether closed-loop yields superior symptom improvement.\n\nParticipants will:\n\nBe randomly assigned to one of the three stimulation group (closed-loop, conventional and random) according to a pre generated random number table, and receive the corresponding stimulation session.\n\nUndergo cue-reactivity assessment using VAS and cue-reactivity task, and complete the SST before and after each stimulation session.",[90,91,92,93],"Methamphetamine Use Disorder","Substance Use Disorder","Cue-reactivity","Craving","NOT_YET_RECRUITING","2026-08-16",{"date":97,"type":98},"2026-08-19","ACTUAL",{"date":100,"type":84},"2026-08",{"date":102,"type":84},"2026-12",{"name":5,"class":6},1]