[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100656199":3},{"organization":4,"outcomesModule":7,"designInfo":31,"detailedDescription":34,"studyPopulation":35,"armGroups":36,"interventions":30,"overallOfficials":43,"centralContacts":48,"locations":30,"responsibleParty":54,"collaborators":30,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":30,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":30,"enrollmentInfo":67,"targetDuration":70,"studyType":71,"phases":30,"briefSummary":72,"conditions":73,"keywords":76,"overallStatus":80,"whyStopped":30,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":30},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":30},[9],{"measure":10,"description":11,"timeFrame":12},"Health-related quality of life score","Mean total score of the Arabic Kidney Disease Quality of Life-36 (KDQOL-36) questionnaire. The KDQOL-36 score ranges from 0 to 100; higher scores indicate better health-related quality of life.","At baseline, 3 months, and 6 months",[14,18,21,24,27],{"measure":15,"description":16,"timeFrame":17},"Dialysis adequacy","Mean single-pool Kt\u002FV (for thrice-weekly) or weekly Kt\u002FV incorporating residual kidney clearance (for twice-weekly).","Up to 6 months",{"measure":19,"description":20,"timeFrame":17},"Residual urine output","Mean daily urine volume (mL\u002Fday) in patients with residual kidney function.",{"measure":22,"description":23,"timeFrame":17},"Hospitalization rate","Proportion of patients requiring hospital admission during follow-up.",{"measure":25,"description":26,"timeFrame":17},"Interdialytic weight gain","Mean interdialytic weight gain (kg).",{"measure":28,"description":29,"timeFrame":17},"Mortality","Proportion of patients who die during the follow-up period.",null,{"allocation":30,"interventionModel":30,"interventionModelDescription":30,"primaryPurpose":30,"observationalModel":32,"timePerspective":33,"maskingInfo":30},"COHORT","PROSPECTIVE","Thrice-weekly maintenance hemodialysis is the conventional schedule. Twice-weekly hemodialysis is used selectively in patients with residual kidney function. Local prospective comparative data in Egypt are limited.\n\nThis observational study will include adults with end-stage kidney disease receiving established twice-weekly or thrice-weekly in-center maintenance hemodialysis. Patients will be followed according to their prescribed schedule without research-driven changes. Health-related quality of life will be assessed using the Arabic KDQOL-36 at baseline, 3 months, and 6 months. Clinical outcomes including adequacy, residual kidney function, hospitalization, and mortality will be recorded.","Adults with end-stage kidney disease receiving maintenance in-center hemodialysis at Assiut University Hospitals.",[37,40],{"label":38,"type":30,"description":39,"interventionNames":30},"Twice-weekly hemodialysis","Adults receiving established twice-weekly maintenance hemodialysis.",{"label":41,"type":30,"description":42,"interventionNames":30},"Thrice-weekly hemodialysis","Adults receiving established thrice-weekly maintenance hemodialysis.",[44],{"name":45,"affiliation":46,"role":47},"marwa k abdo, prof","Internal Medicine Department, Assiut University Hospitals","STUDY_CHAIR",[49],{"name":50,"role":51,"phone":52,"phoneExt":30,"email":53},"Justin g shawky, Resident","CONTACT","01281006606","Justen.18313387@med.aun.edu.eg",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Justin George Shawky Youssef","Resident Physician","100656199","twice-vs-thrice-weekly-hemodialysis-clinical-outcomes-and-quality-of-life-100656199",false,"NCT07821788","Twice vs Thrice Weekly Hemodialysis: Clinical Outcomes and Quality of Life","Clinical Outcomes and Health-Related Quality of Life in Patients Receiving Twice- Versus Thrice-Weekly Maintenance Hemodialysis: A Prospective Comparative Study","Inclusion Criteria:\n\n* \\- Age 18 years or older\n* Established end-stage kidney disease requiring maintenance hemodialysis\n* Receiving in-center maintenance hemodialysis at Assiut University Hospitals\n* On maintenance hemodialysis for at least one month before enrollment\n* Established twice-weekly or thrice-weekly schedule prescribed by the treating team\n* Clinically stable at recruitment\n* Able to understand and respond to the questionnaire\n* Written informed consent\n\nExclusion Criteria:\n\n* \\- Acute kidney injury without established end-stage kidney disease\n* Hemodialysis for less than one month\n* Peritoneal dialysis or kidney transplantation during follow-up\n* Acute severe illness requiring intensive care at recruitment\n* Severe cognitive, psychiatric or neurological impairment preventing reliable questionnaire responses\n* Active malignancy with expected survival too short to complete follow-up\n* Temporary dialysis solely for an acute indication\n* Refusal to participate\n* Permanent transfer to another dialysis center during follow-up","ALL","18 Years",{"count":68,"type":69},130,"ESTIMATED","6 Months","OBSERVATIONAL","This prospective cohort study aims to compare clinical outcomes and health-related quality of life between adults receiving established twice-weekly versus thrice-weekly maintenance hemodialysis at Assiut University Hospitals.",[74,75],"Kidney Failure, Chronic","Quality of Life",[38,41,77,78,79],"KDQOL-36","Residual kidney function","Quality of life","NOT_YET_RECRUITING","2026-09-15",{"date":83,"type":84},"2026-09-17","ACTUAL",{"date":86,"type":69},"2026-09-10",{"date":88,"type":69},"2028-02-10",{"name":5,"class":6}]