[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658215":3},{"organization":4,"outcomesModule":7,"designInfo":62,"detailedDescription":70,"studyPopulation":61,"armGroups":71,"interventions":78,"overallOfficials":84,"centralContacts":88,"locations":93,"responsibleParty":112,"collaborators":61,"id":115,"slug":116,"hasResults":117,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":61,"eligibilityCriteria":121,"healthyVolunteers":122,"sex":123,"minAge":124,"maxAge":125,"enrollmentInfo":126,"targetDuration":61,"studyType":129,"phases":130,"briefSummary":131,"conditions":132,"keywords":134,"overallStatus":96,"whyStopped":61,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":156},{"fullName":5,"class":6},"St. Louis University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":24,"otherOutcomes":61},[9,13,17,21],{"measure":10,"description":11,"timeFrame":12},"Change in 2-Hour Postprandial Glucose Area Under the Curve (AUC)","Postprandial glucose response will be assessed using continuous glucose monitoring during a standardized meal challenge performed before and after the two-week stair-climbing intervention. Glucose area under the curve (AUC) over the approximately 2-hour post-meal period will be calculated using the trapezoidal method and compared between pre- and post-intervention assessments.","Baseline (Day 1) and post-intervention (Day 15)",{"measure":14,"description":15,"timeFrame":16},"Change in CGM-Derived Glucose Standard Deviation","Glucose standard deviation will be calculated from continuous glucose monitoring data over three complete 24-hour periods during the early and late intervention periods and compared within participants.","Early intervention (Days 2-4) and late intervention (Days 11-13)",{"measure":18,"description":19,"timeFrame":20},"Change in Aerobic Capacity (VO₂max or Estimated VO₂max)","Aerobic capacity will be assessed using a VO₂max or estimated VO₂max test with metabolic cart analysis\u002Findirect calorimetry during a graded exercise test. Peak oxygen uptake will be expressed in mL\u002Fkg\u002Fmin and compared between baseline and post-intervention assessments. If a maximal test is not appropriate or feasible, a submaximal test with VO₂ extrapolation may be used.","Baseline (Day 0) and post-intervention (Day 15)",{"measure":22,"description":23,"timeFrame":16},"Change in CGM-Derived Glucose Coefficient of Variation","Glucose coefficient of variation will be calculated from continuous glucose monitoring data over three complete 24-hour periods during the early and late intervention periods and compared within participants.",[25,28,31,34,37,40,43,46,49,52,55,58],{"measure":26,"description":27,"timeFrame":20},"Change in Body Weight","Body weight will be measured using the InBody 380 bioelectrical impedance analysis (BIA) system and compared between baseline and post-intervention assessments.",{"measure":29,"description":30,"timeFrame":20},"Change in Body Fat Percentage","Total body fat percentage will be assessed using the InBody 380 bioelectrical impedance analysis (BIA) system and compared between baseline and post-intervention assessments.",{"measure":32,"description":33,"timeFrame":20},"Change in Fat Mass","Total body fat mass will be assessed using the InBody 380 bioelectrical impedance analysis (BIA) system and compared between baseline and post-intervention assessments.",{"measure":35,"description":36,"timeFrame":20},"Change in Lean Mass","Total lean mass will be assessed using the InBody 380 bioelectrical impedance analysis (BIA) system and compared between baseline and post-intervention assessments.",{"measure":38,"description":39,"timeFrame":20},"Change in Phase Angle","Phase angle will be assessed using the InBody 380 bioelectrical impedance analysis (BIA) system and compared between baseline and post-intervention assessments.",{"measure":41,"description":42,"timeFrame":20},"Change in Waist Circumference","Waist circumference will be measured using a measuring tape at the iliac crest and compared between baseline and post-intervention assessments.",{"measure":44,"description":45,"timeFrame":20},"Change in Wingate Peak Power","Peak anaerobic power will be assessed during a 30-second Wingate anaerobic test performed on a cycle ergometer and compared between baseline and post-intervention assessments.",{"measure":47,"description":48,"timeFrame":20},"Change in Wingate Mean Power","Mean anaerobic power will be assessed during a 30-second Wingate anaerobic test performed on a cycle ergometer and compared between baseline and post-intervention assessments.",{"measure":50,"description":51,"timeFrame":20},"Change in Handgrip Strength","Handgrip strength will be measured using an InBody handgrip dynamometer. The best of three trials for each hand will be recorded, with dominant-hand grip strength used for the primary comparison between baseline and post-intervention assessments.",{"measure":53,"description":54,"timeFrame":20},"Change in Segmental Body Fat Percentage","Segmental body fat percentage will be assessed using the InBody 380 bioelectrical impedance analysis (BIA) system and compared between baseline and post-intervention assessments.",{"measure":56,"description":57,"timeFrame":16},"Change in 24-Hour Mean Glucose","Mean glucose will be calculated from continuous glucose monitoring data over prespecified early- and late-intervention periods and compared within participants.",{"measure":59,"description":60,"timeFrame":16},"Change in Time in Range","The percentage of CGM readings within the prespecified glucose target range will be calculated over early- and late-intervention periods and compared within participants.",null,{"allocation":63,"interventionModel":64,"interventionModelDescription":65,"primaryPurpose":66,"observationalModel":61,"timePerspective":61,"maskingInfo":67},"NA","SINGLE_GROUP","Single-group pre-post pilot study in which all participants complete a two-week stair-climbing exercise snack intervention and undergo baseline and post-intervention assessments.","PREVENTION",{"masking":68,"maskingDescription":69,"whoMasked":61},"NONE","There is no blinding described in the protocol, and practically participants and researchers know that stair climbing is being performed.","This is a pilot intervention study designed to examine the short-term effects and feasibility of frequent stair-climbing \"exercise snacks\" in adults with overweight or obesity. Exercise snacks are brief bouts of physical activity performed intermittently throughout the day and may provide a time-efficient approach to increasing physical activity.\n\nThe study will enroll approximately 12 adults aged 18-35 years with a body mass index of 25.0-34.9 kg\u002Fm² who are otherwise healthy and do not regularly participate in structured exercise. Participants must have regular access to a safe staircase.\n\nParticipants will complete three in-person study visits at Saint Louis University over approximately 15-16 days. Baseline assessments will include anthropometric and body composition measurements, resting cardiovascular measures, handgrip strength, aerobic fitness testing, and anaerobic power testing. Participants will also complete a standardized meal challenge while wearing a continuous glucose monitor to assess postprandial glucose responses.\n\nFollowing baseline testing, participants will complete a two-week stair-climbing intervention. They will perform approximately 6-8 stair-climbing bouts per day for approximately 14 days. Each bout will consist of approximately 60 total stair steps completed at a self-selected challenging but safe pace. Participants may use one or more flights of stairs repeatedly if approximately 60 continuous upward steps are not available. The intervention will be completed in participants' usual daily environments, such as home, work, or campus.\n\nParticipants will wear a continuous glucose monitor during the intervention period and will complete activity, dietary, and study-related logs. After the two-week intervention, participants will repeat the standardized meal challenge and laboratory assessments.\n\nThe primary study outcomes include changes in postprandial glucose response, glycemic variability, and aerobic fitness from baseline to post-intervention. Secondary outcomes include changes in body composition, waist circumference, anaerobic power, and muscular strength. Exploratory outcomes include adherence and feasibility of the stair-climbing intervention.",[72],{"label":73,"type":74,"description":75,"interventionNames":76},"Two-Week Stair-Climbing Exercise Snacks","EXPERIMENTAL","Participants will complete a two-week stair-climbing exercise snack intervention. They will perform approximately 6-8 brief stair-climbing bouts per day for approximately 14 days. Each bout will include approximately 60 total stair steps completed at a self-selected challenging but safe pace. Participants will otherwise be asked to maintain their usual diet and lifestyle and avoid beginning a new exercise or diet program during the study.",[77],"Behavioral: Stair-Climbing Exercise Snacks",[79],{"type":80,"name":81,"description":82,"armGroupLabels":83,"otherNames":61},"BEHAVIORAL","Stair-Climbing Exercise Snacks","Participants will perform brief stair-climbing exercise snacks 6-8 times per day for 14 days. Each bout will consist of approximately 60 total stair steps completed at a self-selected challenging but safe pace. When possible, participants will complete approximately 60 upward steps. If 60 continuous upward steps are not available, participants may use one or more flights repeatedly by ascending and descending carefully until approximately 60 total steps are completed. The intervention will be completed independently in participants' usual daily environments, such as home, work, or campus. Participants will be instructed to use the handrail when needed, descend slowly and carefully, and not run down the stairs.",[73],[85],{"name":86,"affiliation":5,"role":87},"Hossein Rafiei, PhD, RD","PRINCIPAL_INVESTIGATOR",[89],{"name":86,"role":90,"phone":91,"phoneExt":61,"email":92},"CONTACT","314-977-8675","hossein.rafiei@health.slu.edu",[94],{"facility":95,"status":96,"city":97,"state":98,"zip":99,"country":100,"countryCode":101,"cosmosGeoPoint":102,"geoPoint":107,"contacts":108},"Saint Louis University","RECRUITING","St Louis","Missouri","63104","United States","US",{"type":103,"coordinates":104},"Point",[105,106],-90.19789,38.62727,{"lat":106,"lon":105},[109,111],{"name":110,"role":90,"phone":91,"phoneExt":61,"email":92},"Hossein Rafiei, PhD RD",{"name":86,"role":87,"phone":61,"phoneExt":61,"email":61},{"type":87,"investigatorFullName":113,"investigatorTitle":114,"investigatorAffiliation":5,"oldNameTitle":61,"oldOrganization":61},"Hossein Rafiei","Assistant Professor","100658215","two-week-stair-climbing-exercise-snacks-and-metabolic-health-in-adults-with-overweight-or-obesity-a-pilot-study-100658215",false,"NCT07849439","Two-Week Stair-Climbing Exercise Snacks and Metabolic Health in Adults With Overweight or Obesity: A Pilot Study","Effects of a Two-Week Stair-Climbing \"Exercise Snacks\" Intervention on Body Composition, Cardiovascular Fitness, and Metabolic Responses in Overweight and Obese Adults: A Pilot Study","Inclusion Criteria:\n\n* Age 18-35 years and able to provide informed consent.\n* Body mass index (BMI) 25.0-34.99 kg\u002Fm² and otherwise healthy, without chronic disease.\n* Sedentary or low-active lifestyle, defined as no regular structured exercise ≥3 days\u002Fweek for ≥30 minutes per session during the past 3 months.\n* Access to a safe staircase that permits completion of approximately 60 total stair steps per exercise bout. Approximately 60 upward steps are preferred when available; one or more flights may be used repeatedly if needed.\n* No contraindications or increased-risk findings identified on the PAR-Q+ or health history screening.\n\nExclusion Criteria:\n\n* Known cardiovascular, pulmonary, metabolic, renal, neurological, or musculoskeletal disease, or signs or symptoms suggesting increased risk during vigorous exercise, including diagnosed diabetes mellitus, cardiovascular disease, uncontrolled hypertension, chronic pulmonary disease, kidney disease, fainting or unexplained dizziness during exercise, chest pain with exertion, or severe shortness of breath with mild-to-moderate activity.\n* Current use of medications that may affect exercise tolerance, heart-rate response, balance, glucose metabolism, or safety during vigorous exercise, including insulin or other glucose-lowering medications, beta-blockers, anti-arrhythmic medications, systemic corticosteroids, or medications that may cause dizziness, impaired balance, or altered exercise response.\n* Orthopedic or joint conditions that could be aggravated by repeated stair climbing.\n* Allergy, intolerance, dietary restriction, or other condition preventing safe consumption of the standardized meal replacement shake.\n* Pregnancy or plans to become pregnant during the study period.\n* Any other medical or psychological condition that, in the investigator's judgment, could make adherence difficult or place the participant at risk.\n* Individuals currently enrolled in a course taught by the PI or other study personnel, or who are directly supervised, graded, or formally evaluated by a member of the study team.",true,"ALL","18 Years","35 Years",{"count":127,"type":128},12,"ESTIMATED","INTERVENTIONAL",[63],"This pilot study will evaluate whether brief bouts of stair climbing performed throughout the day for two weeks can improve metabolic health, cardiovascular fitness, and other health-related outcomes in adults with overweight or obesity who do not regularly exercise. Participants will complete approximately 6-8 brief stair-climbing \"exercise snacks\" per day for 14 days, with each bout consisting of approximately 60 total stair steps performed at a challenging but safe self-selected pace.\n\nParticipants will complete baseline and post-intervention assessments at Saint Louis University. These assessments will include continuous glucose monitoring and standardized meal testing to evaluate glucose responses, as well as measures of aerobic fitness, anaerobic power, body composition, waist circumference, and muscular strength. The study will also evaluate adherence, perceived exercise intensity, and the feasibility of incorporating brief stair-climbing bouts into daily life.",[133],"Overweight , Obesity",[135,136,137,138,139,140,141,142,143,144,145,146],"Exercise Snacks","Stair Climbing","Physical Activity","Metabolic Health","Postprandial Glucose","Continuous Glucose Monitoring","Glycemic Variability","Cardiorespiratory Fitness","Body Composition","Anaerobic Power","Overweight","Obesity","2026-09-24",{"date":149,"type":150},"2026-09-30","ACTUAL",{"date":152,"type":128},"2026-10",{"date":154,"type":128},"2027-07",{"name":5,"class":6},1]