[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646257":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":11,"centralContacts":33,"locations":39,"responsibleParty":57,"collaborators":61,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":11,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":11,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":11,"overallStatus":42,"whyStopped":11,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Acibadem University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Downhill Walking","EXPERIMENTAL",null,[13,14],"Other: Downhill Aerobic Walking Training","Other: Home exercise session",{"label":16,"type":17,"description":11,"interventionNames":18},"Level Walking","ACTIVE_COMPARATOR",[19,14],"Other: Level Aerobic Walking Training",[21,25,29],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"Downhill Aerobic Walking Training","This involves performing a progressive aerobic exercise program-prescribed based on the results of a 6-minute walk test-twice a week for 8 weeks, at a constant 10-degree downhill, under the supervision of a physical therapist.",[9],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Level Aerobic Walking Training","This involves performing a progressive aerobic exercise program-prescribed based on the results of a 6-minute walk test-twice a week for 8 weeks, at a constant 0-degree (i.e., level) slope, under the supervision of a physical therapist.",[16],{"type":6,"name":30,"description":31,"armGroupLabels":32,"otherNames":11},"Home exercise session","It involves assigning the distance walked during that week's exercise session-conducted under the supervision of a physical therapist-as homework to be walked at home on one day of the same week.",[9,16],[34],{"name":35,"role":36,"phone":37,"phoneExt":11,"email":38},"Meryem Bektaş Karakuş","CONTACT","+90216 500 41 95","meryem.bektas@acibadem.edu.tr",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":11,"country":45,"countryCode":11,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Bezmialem Vakıf University Dragos Hospital","RECRUITING","Istanbul","Maltepe","Turkey (Türkiye)",{"type":47,"coordinates":48},"Point",[49,50],28.94966,41.01384,{"lat":50,"lon":49},[53],{"name":54,"role":36,"phone":55,"phoneExt":11,"email":56},"Yasin Baki Baydaş, M.D.","+90216 251 65 65","ybaydas@bezmialem.edu.tr",{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Meryem BEKTAŞ KARAKUŞ","Research Assistant",[62],{"name":63,"class":6},"Bezmialem Vakif University","100646257","type-2-diabetes-mellitus-and-downhill-aerobic-exercise-training-100646257",false,"NCT07693296","Type 2 Diabetes Mellitus and Downhill Aerobic Exercise Training","The Effect of Downhill Walking Training on Functional Capacity, Peripheral Muscle Strength, and Cardiovascular Responses in Individuals With Type 2 Diabetes Mellitus","Inclusion Criteria:\n\n* Have been diagnosed with Type 2 diabetes mellitus according to the American Diabetes Association (ADA) diagnostic criteria\n* Be able to walk independently and be physically capable of walking on a treadmill\n* Have no acute cardiovascular, neurological, or orthopedic conditions that would prevent participation in the exercise program\n* No major changes to antidiabetic or cardiometabolic treatments within the last 3 months\n* To be under regular follow-up and in a stable clinical condition\n* To have been informed about the study and to provide written informed consent\n\nExclusion Criteria:\n\n* Patients with severe peripheral neuropathy or a lack of protective sensation\n* Lower extremity amputation\n* Diabetic foot ulcer or the presence of severe skin lesions that impair walking\n* Proliferative diabetic retinopathy or advanced retinopathy that could pose a risk of complications during exercise\n* Severe diabetic nephropathy (eGFR \\\u003C30 mL\u002Fmin\u002F1.73 m² or macroalbuminuria \\>300 mg\u002Fg)\n* Uncontrolled hypertension (systolic blood pressure \\>200 mmHg and\u002For diastolic blood pressure \\>110 mmHg)\n* Fasting blood glucose level \\>250 mg\u002FdL with signs of ketosis\n* Unstable angina pectoris, a history of myocardial infarction within the past 6 months, or a history of clinically significant severe arrhythmia\n* Advanced heart failure (NYHA Class III-IV)\n* Having a chronic respiratory disease\n* Having participated in a regular exercise, sports, or physical therapy program within the past 6 months","ALL","18 Years","65 Years",{"count":75,"type":76},34,"ESTIMATED","INTERVENTIONAL",[79],"NA","The purpose of this study is to compare the effects of an 8-week supervised downhill walking training program, prescribed based on the 6-minute walk test, on functional capacity, peripheral muscle strength, and cardiovascular responses in individuals with type 2 diabetes mellitus, as compared to a level walking training program.\n\nParticipants who agree to take part in the study will be randomly assigned to either the downhill or the level-ground walking group. Both groups will undergo a 6-minute walk test (6MWT) at the beginning of the study, and participants will then undergo an 8-week walking training program-conducted twice a week on a treadmill under the supervision of a physical therapist-in which their walking speed is determined based on their average speed during the 6MWT and gradually increased, with the duration of the sessions also being extended.\n\nParticipants will do the following:\n\n* They will participate in walking training sessions at a center twice a week for 8 weeks, under the supervision of a physical therapist.\n* Once a week for 8 weeks, they will walk the same distance they walked with their supervisor that week as a homework assignment.\n* They will come to the facility where they conducted their exercise sessions for evaluations at the beginning of the program and after the 8th week.",[82,83,84],"Diabete Type 2","Aerobic Exercise","Walking","2026-07-07",{"date":87,"type":88},"2026-07-09","ACTUAL",{"date":90,"type":88},"2026-04-01",{"date":92,"type":76},"2027-06-01",{"name":5,"class":6},1]