[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652671":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":10,"centralContacts":78,"locations":88,"responsibleParty":105,"collaborators":107,"id":113,"slug":114,"hasResults":115,"nctId":116,"briefTitle":117,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":115,"sex":120,"minAge":121,"maxAge":10,"enrollmentInfo":122,"targetDuration":125,"studyType":126,"phases":10,"briefSummary":127,"conditions":128,"keywords":137,"overallStatus":91,"whyStopped":10,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":177},{"fullName":5,"class":6},"Kaiser Permanente","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Observational (survey, function tests, biospecimen, actigraphy)",null,"Patients complete surveys, undergo physical function tests, undergo collection of blood and archived tumor samples, and wear an actigraph over 24 hours for a week to record daily sleep and exercise activity at baseline and 3-month follow-up. A sub-sample of patients provide stool samples. Additionally, patients undergo standard of care CT or PET\u002FCT scans throughout the study and patients' medical records are also reviewed at baseline, 3-month and 1-year follow-up.",[13,14,15,16,17,18,19],"Procedure: Biospecimen Collection","Procedure: Computed Tomography","Other: Electronic health record review","Other: Medical Device Usage and Evaluation","Other: Physical functions assessments","Procedure: Positron Emission Tomography (PET)","Other: Survey Administration",[21,30,47,51,55,62,74],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Biospecimen Collection","Undergo collection of blood and archived tumor samples. A sub-sample undergo collection of stool samples.",[9],[27,28,29],"Biological Sample Collection","Biospecimen Collected","Specimen Collection",{"type":22,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"Computed Tomography","Undergo CT or PET\u002FCT scan",[9],[35,36,37,38,39,40,41,42,43,44,45,46],"CAT","CAT Scan","Computed Axial Tomography","Computerized Axial Tomography","Computerized axial tomography (procedure)","Computerized Tomography","Computerized Tomography (CT) scan","CT","CT Scan","Diagnostic CAT Scan","Diagnostic CAT Scan Service Type","tomography",{"type":6,"name":48,"description":49,"armGroupLabels":50,"otherNames":10},"Electronic health record review","Electronic Health Record Review",[9],{"type":6,"name":52,"description":53,"armGroupLabels":54,"otherNames":10},"Medical Device Usage and Evaluation","Wear actigraph",[9],{"type":6,"name":56,"description":57,"armGroupLabels":58,"otherNames":59},"Physical functions assessments","Undergo physical function assessments including 30-second bicep curl, timed up and go (TUG), and 30-second sit to stand",[9],[60,61],"Physical Fitness Testing","Physical Function Testing",{"type":22,"name":63,"description":64,"armGroupLabels":65,"otherNames":66},"Positron Emission Tomography (PET)","Undergo PET\u002FCT scan",[9],[67,68,69,70,71,72,73],"Medical Imaging, Positron Emission Tomography","PET","PET Scan","Positron emission tomography (procedure)","Positron Emission Tomography Scan","Positron-Emission Tomography","PT",{"type":6,"name":75,"description":76,"armGroupLabels":77,"otherNames":10},"Survey Administration","Complete surveys",[9],[79,84],{"name":80,"role":81,"phone":82,"phoneExt":10,"email":83},"Elizabeth M Cespedes Feliciano, ScD, SM","CONTACT","(510) 414-4154","Elizabeth.M.Cespedes@kp.org",{"name":85,"role":81,"phone":86,"phoneExt":10,"email":87},"Michelle C Ross, MPH","(925) 520-0650","michelle.c.ross@kp.org",[89],{"facility":90,"status":91,"city":92,"state":93,"zip":94,"country":95,"countryCode":96,"cosmosGeoPoint":97,"geoPoint":102,"contacts":103},"Kaiser Permanente Northern California","RECRUITING","Pleasanton","California","94588","United States","US",{"type":98,"coordinates":99},"Point",[100,101],-121.87468,37.66243,{"lat":101,"lon":100},[104],{"name":85,"role":81,"phone":86,"phoneExt":10,"email":87},{"type":106,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[108,111],{"name":109,"class":110},"National Cancer Institute (NCI)","NIH",{"name":112,"class":6},"Cancer Research UK","100652671","understanding-new-cachexia-subtypes-through-observational-epidemiological-research-100652671",false,"NCT07776353","Understanding New Cachexia Subtypes Through Observational Epidemiological Research","UNCOVER","Inclusion Criteria:\n\n* Have a primary diagnosis of unresectable or Stage IV 1) non-small cell lung cancer (NSCLC), 2) pancreatic adenocarcinoma, or 3) colorectal cancer (CRC).\n\nNote: Patients do not need to have cachexia to be eligible\n\n* Plan to start first line systemic anti-cancer therapy (chemotherapy, immunotherapy, targeted therapy) in the next 6 weeks or has started first-line systemic therapy in the previous 6 weeks.\n\nNote: Patients who received systemic anti-cancer therapy previously as part of adjuvant or neoadjuvant therapy and have since recurred are still eligible if such treatment was longer than 6 months prior to enrollment.\n\n* Have an an Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2.\n* Be able to understand, speak and read English.\n* Be 18 years or older\n\nExclusion Criteria:\n\n* Have contraindications to physical function assessments (30-second bicep curl, Timed-Up-And-Go test, or 30-Second Sit to Stand test) per the treating provider or their designee.\n* Have any planned major surgeries within the next 3 months after enrollment to the best knowledge of the investigator\u002Ftreating provider or their designee.\n* Have received chemotherapy or surgery for separate primary cancer within the past 3 years other than non-melanoma skin cancer.\n* Be pregnant or within 6 months postpartum.","ALL","18 Years",{"count":123,"type":124},800,"ESTIMATED","1 Year","OBSERVATIONAL","The UNCOVER study is a longitudinal observational cohort focused on patients at high risk for cancer cachexia. At Kaiser Permanente Northern California, up to 800 individuals with advanced or unresectable non-small cell lung cancer, pancreatic adenocarcinoma, or colorectal cancer will be enrolled, as these malignancies carry a substantial risk of cancer cachexia, which is characterized by progressive loss of weight, muscle, and adipose tissue, accompanied by functional decline and reduced quality of life. Data collected includes demographic, physiologic, and clinical data, including tumor characteristics and biomarkers of inflammation, hormonal and metabolic status, body composition, physical function, and patient reported outcomes. Investigators will identify patient phenotypes (i.e., subgroups) that may reflect distinct biological or clinical pathways underlying cancer cachexia. By characterizing heterogeneity in cancer cachexia, this study aims to inform the development of improved diagnostic criteria and more targeted therapeutic strategies, ultimately enhancing clinical trial design and supportive care for patients with advanced colorectal, lung, or pancreatic cancer.",[129,130,131,132,133,134,135,136],"Advanced Colorectal Carcinoma","Advanced Lung Non-Small Cell Carcinoma","Advanced Pancreatic Adenocarcinoma","Stage IV Colorectal Cancer AJCC v8","Stage IV Lung Cancer AJCC v8","Stage IV Pancreatic Cancer AJCC v8","Unresectable Colorectal Carcinoma","Unresectable Lung Non-Small Cell Carcinoma",[138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154,155,156,157,158,159,160,161,162,163,164,165,166,167],"Intestinal Neoplasms","Gastrointestinal Neoplasms","Digestive System Neoplasms","Neoplasms by Site","Neoplasms","Digestive System Diseases","Gastrointestinal Diseases","Colonic Diseases","Intestinal Diseases","Rectal Diseases","Respiratory Tract Neoplasms","Thoracic Neoplasms","Lung Diseases","Respiratory Tract Diseases","Endocrine Gland Neoplasms","Pancreatic Diseases","Endocrine System Diseases","Colorectal Neoplasms","Lung Neoplasms","Pancreatic Neoplasms","Clinical Laboratory Techniques","Diagnostic Techniques and Procedures","Diagnosis","Investigative Techniques","Heart Function Tests","Diagnostic Techniques, Cardiovascular","Respiratory Function Tests","Diagnostic Techniques, Respiratory System","Specimen Handling","Exercise Test","2026-08-17",{"date":170,"type":171},"2026-08-20","ACTUAL",{"date":173,"type":171},"2023-04-05",{"date":175,"type":124},"2028-05",{"name":5,"class":6},1]